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Knowledge and practice of health care workers towards post exposure prophylaxis in the era of low and stable HIV prevalence in Southwestern Nigeria
Publication date: June 2018Source: Bulletin of Faculty of Pharmacy, Cairo University, Volume 56, Issue 1Author(s): Wasiu Olalekan AdebimpeAbstractNigeria ranks top among the countries with the highest burden of Human Immune-deficiency Virus (HIV) infection. Despite ready-made access to HIV care, Post-Exposure Prophylaxis (PEP) practices have not increased commensurately due to several gaps within the health sector. This research was undertaken to assess knowledge and practice of health care workers towards PEP of HIV in Southwestern Nigeria. A descriptive cross sectional study was carried out among 300 health care workers ...
Source: Bulletin of Faculty of Pharmacy, Cairo University - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

Exploring community pharmacists’ knowledge, perception and experiences towards branded and generic medicines in Kuwait: Highlighting the role of pharmacist
ConclusionA national brand substitution policy should be formulated and implemented to assist pharmacists in the proper substitution practice and to help minimize the healthcare costs. (Source: Bulletin of Faculty of Pharmacy, Cairo University)
Source: Bulletin of Faculty of Pharmacy, Cairo University - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

Notes on the genus Paramignya: Phytochemistry and biological activity
Publication date: June 2018Source: Bulletin of Faculty of Pharmacy, Cairo University, Volume 56, Issue 1Author(s): Ninh The SonAbstractGenus Paramignya belongs to Rutaceae family, with interesting secondary metabolites, comprising main classes of compounds coumarin and coumarin glycosides, acridone alkaloids, tirucallane and tirucallane glycosides, phenols, and flavonoids, as well as several compounds limonoid, lignin glycoside and sterol. Paramignya species has been employing as folk medicines against hepatitis, diabetes, cancer, nose infections. Many bioactive reported such as cytotoxic assay, antioxidant, antiinflammato...
Source: Bulletin of Faculty of Pharmacy, Cairo University - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

Chronomodulated drug delivery system of Irbesartan: Formulation and development using Desing of Experiment (DoE)
Publication date: June 2018Source: Bulletin of Faculty of Pharmacy, Cairo University, Volume 56, Issue 1Author(s): Komal Parmar, Almas Shaikh, Hitesh DalvadiAbstractThe work is based on pulsatile principles to deliver a programmed dose of Irbesartan, an angiotensin-II receptor antagonist for chronotherapy of hypertension induced by excessive secretion of aldosterone, thereby lower the blood pressure at early morning. Solid dispersion of Irbesartan, a BCS class II drug, was prepared by using Poloxamer-188 by melt method in ratio of 1:1 to increase the dissolution properties of drug. Compressed coated pulsatile tablets inclu...
Source: Bulletin of Faculty of Pharmacy, Cairo University - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

Quality risk management during pharmaceutical ‘good distribution practices’ – A plausible solution
This study addresses the gap in literature on quality risk management during supply chain operations. There are cases of unresolved customer complaints and batch failures originated due to inadequacies during distribution of pharmaceutical products. In absence of established quality risk management system during product shipment, there is no effective preventive plan related to risk factors. A corollary of manufacturing quality risk management has been drawn to the distribution of pharmaceutical products through this study. The quality risk management during pharmaceutical distribution may be useful to avoid market complai...
Source: Bulletin of Faculty of Pharmacy, Cairo University - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

In vitro permeation and stability studies on developed drug-in-adhesive transdermal patch of simvastatin
Publication date: June 2018Source: Bulletin of Faculty of Pharmacy, Cairo University, Volume 56, Issue 1Author(s): Rabinarayan Parhi, Suresh PadilamAbstractThe transdermal drug-in-adhesive (DIA) patch of simvastatin (SM) was developed using acrylic adhesives such as DURO-TAK® 87-9301, DURO-TAK® 87-4287, DURO-TAK® 87-235A. The patches were evaluated for in vitro drug permeation across the pork ear skin using diffusion cell and stability studies. Among the three acrylic adhesives used, DURO-TAK® 87-9301 exhibited maximum flux (5.18 ± 0.23 µg/cm2/h). To further enhance the drug permeation, isopropyl myristate (IPM...
Source: Bulletin of Faculty of Pharmacy, Cairo University - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

A comparative study of in vitro antimicrobial, antioxidant and cytotoxic activity of Albizia lebbeck and Acacia nilotica stem bark
Publication date: June 2018Source: Bulletin of Faculty of Pharmacy, Cairo University, Volume 56, Issue 1Author(s): Mohammad Tuhin Ali, Sheikh Tanzina Haque, Md. Lutful Kabir, Sohel Rana, Md. Enamul HaqueAbstractPetroleum ether, ethyl acetate and methanol extracts of the stem bark of Albizia lebbeck and Acacia nilotica was investigated for antimicrobial, antioxidant and cytotoxicity assay. The powdered stem bark was extracted successively with petroleum ether, ethyl acetate and methanol solution. The crude extracts were subjected to antimicrobial, antioxidant and cytotoxicity assay by using disc diffusion method, DPPH and h...
Source: Bulletin of Faculty of Pharmacy, Cairo University - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

Radical scavenging potential, antiinflammatory and antiarthritic activity of isolated isomer Methyl-γ-Orsellinate and roccellatol from Roccella montagnei Bel
Publication date: June 2018Source: Bulletin of Faculty of Pharmacy, Cairo University, Volume 56, Issue 1Author(s): Syed Zameer Ahmed Khader, Sidhra Syed Zameer Ahmed, Thangakumar Arunachalam, Sanjeeva Nayaka, Senthil Kumar Balasubramanian, Syed Tajudeen SyedAmeen, Ponmurugan PonnusamyAbstractThe burden of multiple drug resistance towards chronic diseases is rapidly increasing globally at an alarm rate. The present study aims to isolate active principles via bioassay guided fractionation of traditionally used lichen Roccella montagnei for in vitro radical scavenging activity with potential to combat arthritis and inflammati...
Source: Bulletin of Faculty of Pharmacy, Cairo University - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

The high lymphadenopathy and subcutaneous edema are associated with development of foot ulcer in type 2 diabetes: A collagen implanted antibiotic therapy
In this study, the possible efforts were made to prevent the diabetic foot ulcer of a patient. The diabetic foot ulcer, with tissue exposure and microbial infection on the surface of the foot, was treated with several antibiotics and dressings. The revascularization treatment procedure was started. The infection was reduced when compared with the beginning of this treatment. The collagen implant along with Gentamicin sulphate found that collagen was penetrated into the wound and helped the granulation of the tissue formation. The topical gentamicin reduced the bacterial contamination and cicatrization. The infective diabet...
Source: Bulletin of Faculty of Pharmacy, Cairo University - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

Sapium ellipticum (Hochst) Pax leaf extract: Antioxidant potential in CCl4-induced oxidative stress model
ConclusionSE extract appears to have the phyto-proficiency to protect against membrane peroxidation and improve the activities of some first line antioxidant enzymes such a SOD and CAT in vivo. This is probably due to its array of bioactive compounds (α-tocopherol, amentoflavone and lupeol) which we have previously identified and reported. (Source: Bulletin of Faculty of Pharmacy, Cairo University)
Source: Bulletin of Faculty of Pharmacy, Cairo University - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

Anti-hyperglycaemic activity of tuber extract of Chlorophytum alismifolium Baker in streptozotocin-induced hyperglycaemic rats
In conclusion, the results obtained suggest the tuber extract of Chlorophytum alismifolium possesses antihyperglycaemic activity.Graphical abstract (Source: Bulletin of Faculty of Pharmacy, Cairo University)
Source: Bulletin of Faculty of Pharmacy, Cairo University - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

Identification of possible Ser/Thr/Tyr phosphorylation sites in the fungal histidine kinase CaNik1p by peptide array technique
In this study, we aimed to identify additional possible P-sites in this HK. Therefore, we constructed a peptide array that covers the full length protein. Incubation of the purified His-tagged CaNik1p with the peptide array in the presence of radioactive ATP [γ-32P] revealed the possible P-sites in each peptide. We classified the peptides according to their intensities. Peptides bearing His510 and D924 showed either null or very weak intensities. The highest intensity was corresponding to the peptide containing the amino acid T994, while lower intensities were related mainly to serine and threonine residues and to lower e...
Source: Bulletin of Faculty of Pharmacy, Cairo University - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

Validated determination of diacerein and its active metabolite, rhein, by stability indicating constant pattern method as a novel manipulation of zero order spectra
Publication date: June 2018Source: Bulletin of Faculty of Pharmacy, Cairo University, Volume 56, Issue 1Author(s): Aml A. Emam, Nouruddin W. AliAbstractA novel spectrophotometric method named constant absorbance pattern technique was proposed for simple determination of binary mixtures exemplified by diacerein, a treatment of osteoarthritis, and rhein, diacerein main alkaline degradation product and active metabolite. The proposed novel constant absorbance pattern technique was highly accurate, precise, sensitive, specific and stability indicating as well. The proposed technique allowed determination of diacerein and rhein...
Source: Bulletin of Faculty of Pharmacy, Cairo University - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

In vitro activity of dihydropyrazole derivatives against Candida species
In this study, we investigate the efficacy of different benzodioxolpyrazoline derivatives against two Candida species. All compounds exhibited potent in vitro antifungal activity against both species. Compound 5 showed the best inhibition zone in comparison to positive controls for Candida albicans. For Candida parapsilosis, all the tested compounds were active while the positive controls were inactive. These compounds provide good starting models for the development of new antimicrobial agents which could be useful especially for the treatment of candidiasis. (Source: Bulletin of Faculty of Pharmacy, Cairo University)
Source: Bulletin of Faculty of Pharmacy, Cairo University - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

Quinazolino-thiadiazoles as antimicrobial agents
Publication date: June 2018Source: Bulletin of Faculty of Pharmacy, Cairo University, Volume 56, Issue 1Author(s): Harun Patel, Atul Shirkhedkar, Sanjay Bari, Kamalkishor Patil, Amit Arambhi, Chandrakantsing Pardeshi, Abhijeet Kulkarni, Sanjay SuranaAbstractIn the present research, we report the synthesis and in vitro antimicrobial activity of a new series of novel quinazolino-thiadiazoles as fused pharmacophore (3–20). In general, the results of the in vitro antibacterial activity are encouraging, as out of 18 compounds tested, Compounds 3 and 8 with a 4-chlorophenyl and 4-nitro phenyl at C-2 of thiadiazole and chlorome...
Source: Bulletin of Faculty of Pharmacy, Cairo University - July 5, 2018 Category: Drugs & Pharmacology Source Type: research