Bulletin of Faculty of Pharmacy, Cairo University 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Protective effect of standardized extract of Biophytum sensitivum against calcium oxalate urolithiasis in rats
Conclusions These results indicated that the MBS reduced and prevented the growth of urinary stones. However, cystone (500mg/kg) is more effective than the MBS (400mg/kg) in alleviating the urolithiasis. This finding supports the traditional use of B. sensitivum for urolithiasis. (Source: Bulletin of Faculty of Pharmacy, Cairo University)
Source: Bulletin of Faculty of Pharmacy, Cairo University - October 23, 2015 Category: Drugs & Pharmacology Source Type: research
Enhanced photocatalytic–biological degradation of 2,4 dichlorophenoxyacetic acid
In this study the most effective method of its degradation and bioremediation has been studied. Two microbial consortia capable of utilizing 2,4-D as a sole source of carbon were isolated from the Egyptian environment. One of the microbial consortia interestingly contained a certain kind of protozoa as one of the mixed consortia members. Degradation of 2,4-D by the microbial consortia was affected by 2,4-D initial concentration, agitation, pH of the medium and temperature. The two consortia were able to degrade up to 700mgl−1 of 2,4-D. Pre-treatment with UV radiations in the presence of photocatalyst such as TiO2 acceler...
Source: Bulletin of Faculty of Pharmacy, Cairo University - June 19, 2015 Category: Drugs & Pharmacology Source Type: research
Hepatoprotective and antioxidant polyphenols from a standardized methanolic extract of the leaves of Liquidambar styraciflua L.
Publication date: Available online 11 June 2015 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Hanaa H. Eid , Rola M. Labib , Nagy S. Abdel Hamid , Manal A. Hamed , Samir A. Ross The methanolic extract of the leaves of Liquidambar styraciflua L. (Altingiaceae) (LSE) was evaluated for hepatoprotective and antioxidant activities in carbon tetrachloride liver-damaged rats. Hepatotoxicity was induced via intraperitoneal injection of CCl4 1:9 in olive oil, at a dose of 0.5ml/kg b.wt. The animals received the extract, orally, at two dose levels (250 and 500mg/kg b.wt.) The administration regimen was...
Source: Bulletin of Faculty of Pharmacy, Cairo University - June 12, 2015 Category: Drugs & Pharmacology Source Type: research
Design, synthesis, molecular docking and anticonvulsant evaluation of novel 6-iodo-2-phenyl-3-substituted-quinazolin-4(3H)-ones
Publication date: Available online 28 May 2015 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Mohamed-Kamal Ibrahim , Khaled El-Adl , Ahmed A. Al-Karmalawy A new series of 6-iodo-2-phenyl-3-substituted-quinazolin-4(3H)-one (5–12a–b ) derivatives were synthesized, evaluated for their anticonvulsant activity against pentylenetetrazole (PTZ)-induced seizures and maximal electroshock test and compared with the reference drugs phenobarbital sodium and methaqualone. The neurotoxicity was assessed using rotarod test. The molecular docking was performed for all the synthesized compounds to assess th...
Source: Bulletin of Faculty of Pharmacy, Cairo University - May 30, 2015 Category: Drugs & Pharmacology Source Type: research
LC–MS/MS based-comparative study of (S)-nicotine metabolism by microorganisms, mushroom and plant cultures: Parallels to its mammalian metabolic fate
Publication date: Available online 19 May 2015 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Amira R. Khattab , Abdel-Rahim S. Ibrahim , Souzan M. Ibrahim , Kamillia A. Abou El-Seoud , Wafaa E. Soliman , Fathy K. El-Fiky The metabolic fate of nicotine using the cell cultures of microorganisms, mushroom and plants was explored using LC–MS/MS analysis. The study demonstrated parallels to phase I mammalian metabolism of nicotine and reported that nicotine was biotransformed into its N-oxide by Streptomyces fradiae culture. Moreover, it was metabolized in Pleurotus ostreatus culture into norni...
Source: Bulletin of Faculty of Pharmacy, Cairo University - May 20, 2015 Category: Drugs & Pharmacology Source Type: research
Chiral separation of (d)- and (l)-enantiomers of doxylamine succinate in rat plasma
Publication date: Available online 16 May 2015 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Tadiboyina Sirisha , Bannimath Gurupadayya , Bharathkumar Inturi A selective chiral ultra fast liquid chromatography (UFLC-DAD) method was developed and validated to separate and quantify the (d)- and (l)-enantiomers of doxylamine in rat plasma. After extraction of the plasma samples with acetonitrile, the separation of doxylamine succinate enantiomers and internal standard (I.S., diphenhydramine hydrochloride) was achieved on a cellulose Tris (4-chloro,3-methylphenylcarbamate) column with a mobile phas...
Source: Bulletin of Faculty of Pharmacy, Cairo University - May 17, 2015 Category: Drugs & Pharmacology Source Type: research
Pharmacophore mapping studies on indolizine derivatives as 15-LOX inhibitors
Publication date: Available online 25 March 2015 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Vikas Sharma , Vipin Kumar This investigation analyzes the common chemical features for 15-lipoxygenase (15-LOX) inhibitors to develop ligand-based pharmacophore models for lipoxygenase inhibitory activity. The present model is based on a dataset of 47 indolizine derivatives that exhibit inhibition against 15-LOX enzyme isolated from soybeans. Pharmacophore models were developed with pharmacophoric features namely: aromatic ring (R) and hydrogen bond acceptor (A). The pharmacophore hypothesis ARRR.5 wi...
Source: Bulletin of Faculty of Pharmacy, Cairo University - March 26, 2015 Category: Drugs & Pharmacology Source Type: research
Alleviation of haloperidol induced oxidative stress in rats: Effects of sucrose vs grape seed extract
Publication date: Available online 21 March 2015 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Sally A. El-Awdan , Gehad A. Abdel Jaleel , Dalia O. Saleh Haloperidol (HP) is a classic antipsychotic drug known for its propensity to cause extrapyramidal side effects. HP is known to induce oxidative stress due to increased turnover of dopamine. The aim of the present study was to investigate the effect of sucrose (1 and 5mg/kg; p.o.) and grape seed extract (GSE; 100, 200 and 400mg/kg; p.o.) on the oxidative stress induced in rats by HP (1mg/kg; p.o.) in the liver and the brain tissues. Oxidative s...
Source: Bulletin of Faculty of Pharmacy, Cairo University - March 22, 2015 Category: Drugs & Pharmacology Source Type: research
Egyptian Pancratium maritimum L. flowers as a source of anti-Alzheimer’s agents
Publication date: Available online 9 March 2015 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): M.M. Soltan , A.R. Hamed , M.H. Hetta , A.A. Hussein Elevation of acetylcholinesterase enzyme (AChE) has been reported to be implicated in the etiology of Alzheimer disease (AD). One of the encouraged strategies to fight AD is the plant-derived inhibitors. Amaryllidaceae species are enriched source of alkaloids. The inhibitory properties of roots and bulbs of Pancratium maritimum L. against AChE have been previously reported. In the present study, the flowers of the wild Egyptian P. maritimum were sub...
Source: Bulletin of Faculty of Pharmacy, Cairo University - March 10, 2015 Category: Drugs & Pharmacology Source Type: research
Naturally occurring didemnaketals: Structural elucidation, features, and pharmacological activities
Publication date: Available online 3 March 2015 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Gamal A. Mohamed , Sabrin R. M. Ibrahim , Diaa T. A. Youssef Didemnaketals are rare terpenoid class reported only in the marine ascidian Didemnum species. They possess important biological activities like HIV-1 protease inhibitor, protein kinase inhibition, antimicrobial, antiproliferative, and cytotoxic. A compilation of new naturally occurring didemnaketals reported during 1991–2014 is provided with available physical and spectral data: mp, [α]D, UV, IR, 1H and 13C NMR as well as biological activi...
Source: Bulletin of Faculty of Pharmacy, Cairo University - March 5, 2015 Category: Drugs & Pharmacology Source Type: research
New diacyl flavonoid derivatives from the Egyptian plant Blepharis edulis (Forssk.) Pers.
Publication date: Available online 21 February 2015 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Mohamed Abdel-Ghaffar Ashour In continuation of our phytochemical investigation of Blepharis edulis (Forssk.) Pers., family Acanthaceae; two new diacyl flavone derivatives: apigenin-7-O-(2″-acetyl-6″-E-p-coumaroyl-β-d-glucopyranoside) (1) and apigenin-7-O-(4″-acetyl-6″-E-p-coumaroyl-β-d-glucopyranoside) (2), along with eight known compounds: apigenin-7-O-(3″-acetyl-6″-E-p-coumaroyl-β-d-glucopyranoside) (3), naringenin-7-O-(3″-acetyl-6″-E-p-coumaroyl-β-d-glucopyranoside) (4), apige...
Source: Bulletin of Faculty of Pharmacy, Cairo University - February 22, 2015 Category: Drugs & Pharmacology Source Type: research
Investigation of the profile and kinetics of degradation of Rivaroxaban using HPLC, TLC-densitometry and LC/MS/MS: Application to pre-formulation studies
Publication date: Available online 13 February 2015 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Mohamed A. Abdallah , Medhat A. Al-Ghobashy , Hayam M. Lotfy Rivaroxaban (RIVA), an amide group-containing oral anticoagulant was subjected to stress conditions commonly required for the registration of pharmaceuticals: base and acid-catalyzed hydrolysis (0.1M, 60°C, 3–6h), oxidation (10% H2O2, 24h), photodegradation (300–800nm, 24h) and thermal decomposition (50°C, 6h). Two major degradation products were separated and identified using TLC and LC/MS/MS, respectively. An orthogonal stability-...
Source: Bulletin of Faculty of Pharmacy, Cairo University - February 15, 2015 Category: Drugs & Pharmacology Source Type: research
Iridoids and other constituents from Cyperus rotundus L. rhizomes
Publication date: Available online 2 February 2015 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Gamal A. Mohamed On continuation of the phytochemical investigation of the MeOH extract of Cyperus rotundus L. Rhizomes, four compounds namely, methyl 3,4-dihydroxy benzoate (1), ipolamiide (2), 6β-hydroxyipolamiide (3), and rutin (4) were isolated. Their structures were established on the basis of 1D and 2D NMR spectroscopic analyses as well as ESIMS spectral data. Compounds 2 and 3 are reported here for the first time from the genus Cyperus and 1 for the first time from the plant. Co-treatment of C...
Source: Bulletin of Faculty of Pharmacy, Cairo University - February 3, 2015 Category: Drugs & Pharmacology Source Type: research
Synthesis and anti-mycobacterial evaluation of some new isonicotinylhydrazide analogues
Publication date: Available online 5 December 2014 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Maha A. Elhakeem , Azza T. Taher , Suzan M. Abuel-Maaty The synthesis of some new 3,4-disubstituted thiazolylideneisonicotinohydrazide derivatives 3a–k, 2-substituted thiazolidinylisonicotinamide derivatives 4a–d and pyrrolylisonicotinamide derivatives 5, 6 and 7 is described. The resulted compounds are evaluated for their in vitro antitubercular activity. The minimum inhibitory concentration (MIC) of compound 3g showed comparable in vitro activity to isoniazid against Mycobacterium tuberculosis...
Source: Bulletin of Faculty of Pharmacy, Cairo University - December 6, 2014 Category: Drugs & Pharmacology Source Type: research
Hepatoprotective potential of Saraca ashoka (Roxb.) De Wilde bark by carbon tetrachloride induced liver damage in rats
Conclusion The results suggest that MESA and HAESA extracts at doses of 200 and 400mg/kg, p.o. have a significant effect on the liver of CCl4 induced hepatotoxicity animal model. (Source: Bulletin of Faculty of Pharmacy, Cairo University)
Source: Bulletin of Faculty of Pharmacy, Cairo University - December 6, 2014 Category: Drugs & Pharmacology Source Type: research
