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Combined hepatoprotective and antidepressant effects of resveratrol in an acute model of depression
In this study we examined the hepatoprotective and antidepressant effects of trans-resveratrol against fluoxetine in an acute reserpine model of depression in rats. Main methods: depression-like behaviors were induced by single reserpine intraperitoneal injection (6mg/kg, i.p.). Trans-resveratrol (15, 30 and 60mg/kgbwt) and fluoxetine (24mg/kgbwt) were administered orally for the following 3days. Behavioral effects namely open field test (OFT) and forced swimming test (FST) and biochemical parameters namely neurotransmitters levels and antioxidant contents were assessed. Liver histopathological examination was performed. K...
Source: Bulletin of Faculty of Pharmacy, Cairo University - October 13, 2014 Category: Drugs & Pharmacology Source Type: research

Bacterial vs. fungal spore resistance to peroxygen biocide on inanimate surfaces
Publication date: Available online 7 August 2014 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Mostafa Essam Eissa , Mohab Abd El Naby , Mohamed Mohamed Beshir A sporicidal agent formula based on a mixture of peroxyacetic acid and hydrogen peroxide was assessed for its efficacy on a representative sample of vinyl surface material. Vinyl is the construction material of wall and floor lining in pharmaceutical plants. The experimental manipulations; applied herein, simulated the actual biocidal agent preparation and were carried out using USP purified water, test temperature was 20–25°C, RH% wa...
Source: Bulletin of Faculty of Pharmacy, Cairo University - October 13, 2014 Category: Drugs & Pharmacology Source Type: research

Validated HPTLC methods for determination of some selected antihypertensive mixtures in their combined dosage forms
Publication date: Available online 14 August 2014 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Rasha A. Shaalan , Tarek S. Belal , Fawzy A. El Yazbi , Sohila M. Elonsy Simple and selective HPTLC methods were developed for the simultaneous determination of the antihypertensive drugs; carvedilol and hydrochlorothiazide in their binary mixture (Mixture I) and amlodipine besylate, valsartan, and hydrochlorothiazide in their combined ternary formulation (Mixture II). Effective chromatographic separation was achieved on Fluka TLC plates 20×20cm aluminum cards, 0.2mm thickness through linear ascend...
Source: Bulletin of Faculty of Pharmacy, Cairo University - October 13, 2014 Category: Drugs & Pharmacology Source Type: research

Beneficial effects of certain phosphodiesterase inhibitors on diabetes mellitus in rats
Publication date: Available online 20 August 2014 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): A.S. El-Deeb , N.I. Eid , M.E. El-Sayed The present study is conducted to investigate the possible antidiabetic effect of certain phosphodiesterase inhibitors. Diabetes mellitus was induced in 18h-fasted male wistar albino rats by intraperitoneal injection of streptozotocin (STZ) in a single dose (50mg/kg). Gliclazide (Glcl) as a reference standard in a dose of 10mg/kg, sildenafil (Sild) in 3 doses (5, 10, 20mg/kg) as PDE5 inhibitor and vinpocetine (Vinp) in 3 doses (10, 20, 40mg/kg) as PDE1 inhibito...
Source: Bulletin of Faculty of Pharmacy, Cairo University - October 13, 2014 Category: Drugs & Pharmacology Source Type: research

Synthesis, antimicrobial screening and structure–activity relationship of novel pyrimidines and their thioethers
Publication date: Available online 6 September 2014 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Chetan M. Bhalgat , B. Ramesh In the present study, a series of novel pyrimidines (1) and their thioethers (2–5) were synthesized. Structures of the synthesized compounds were established by IR, 1H NMR, 13C NMR mass spectral data and elemental analysis. All the newly synthesized compounds were screened for their in vitro antibacterial and antifungal activities. Among the compounds tested, few were found to be most effective antibacterial and antifungal agents. The Structure–activity relationship...
Source: Bulletin of Faculty of Pharmacy, Cairo University - October 13, 2014 Category: Drugs & Pharmacology Source Type: research

Anti-arthritic activity of Barleria prionitis Linn. leaves in acute and chronic models in Sprague Dawley rats
Conclusion In the present investigation, extract protects synovial membrane by improving the health status through haematinic parameters and exhibits promising anti-arthritic activity. This finding thus supports the traditional use of Barleria prionitis for rheumatism. However, further studies are needed to carry out the isolation of active constituents of the fraction responsible for the activity. (Source: Bulletin of Faculty of Pharmacy, Cairo University)
Source: Bulletin of Faculty of Pharmacy, Cairo University - October 13, 2014 Category: Drugs & Pharmacology Source Type: research

HPLC method validation for modernization of the tetracycline hydrochloride capsule USP monograph
Publication date: Available online 26 September 2014 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Emad M. Hussien This paper is a continuation to our previous work aiming at development and validation of a reversed-phase HPLC for modernization of tetracycline-related USP monographs and the USP general chapter <226>. Previous results showed that the method is accurate and precise for the assay of tetracycline hydrochloride and the limit of 4-epianhydrotetracycline impurity in the drug substance and oral suspension monographs. The aim of the current paper is to examine the feasibilit...
Source: Bulletin of Faculty of Pharmacy, Cairo University - October 13, 2014 Category: Drugs & Pharmacology Source Type: research

A Validated Stability Indicating HPTLC Method for Estimation of Acyclovir in Tablets in presence of its alkaline hydrolysis degradation product
Publication date: Available online 1 October 2014 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Pallavi M. Patil , Sagar B. W.hede , Praveen D. Chaudhari A sensitive stability indicating high-performance thin-layer chromatographic method was developed and validated for quantitative determination of Acyclovir in tablets. Chromatographic separation was performed on a precoated silica gel 60F254 HPTLC plates using Toluene: n-Butanol: Methanol: Water (5.0:3.0:1.0:1.0 v/v/v/v) as a mobile phase. A TLC scanner set at 259nm was used for direct evaluation of the chromatograms in reflectance/absorbance ...
Source: Bulletin of Faculty of Pharmacy, Cairo University - October 13, 2014 Category: Drugs & Pharmacology Source Type: research