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Multivariate optimization for simultaneous determination of aspirin and simvastatin by reverse phase liquid chromatographic method using AQbD approach
Publication date: Available online 12 September 2017 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Kalpana G. Patel, Apeksha T. Patel, Purvi A. Shah, Tejal R. Gandhi The present study describes the development of a robust method for the separation of aspirin and simvastatin using reverse phase high performance liquid chromatographic method on Kintex reverse phase C18 column (5μm, 250mm×4.6mm) with UV detection at 234nm. Box-Behnken design was applied for multivariate optimization of the experimental conditions of RP-HPLC for obtaining desired chromatographic resolution with limited number of e...
Source: Bulletin of Faculty of Pharmacy, Cairo University - September 13, 2017 Category: Drugs & Pharmacology Source Type: research

Acute and subchronic toxicity evaluation of methanol stem-bark extract of Ximenia americana Linn (Olacaceae) in Wistar rats
In conclusion, acute oral administration of methanol stem-bark extract of Ximenia americana was relatively non-toxic in mice, but minimal anatomical changes in kidney, lungs and spleen occurred when used for few weeks in rats. (Source: Bulletin of Faculty of Pharmacy, Cairo University)
Source: Bulletin of Faculty of Pharmacy, Cairo University - September 12, 2017 Category: Drugs & Pharmacology Source Type: research

Experimental animal models used for evaluation of potential immunomodulators: A mini review
Publication date: Available online 5 September 2017 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Aditya Ganeshpurkar, Ajay K. Saluja Preclinical models of immunomodulatory studies are indispensable part in the process of drug discovery and development. Still, they are mimeo of human immunostimulation/suppression provided heterogeneity of latter. This review discusses various preclinical models of immunomodulatory studies viz. cell lines for immunomodulatory studies, murine models include humoral antibody (HA) response, delayed type hypersensitivity response, macrophage phagocytosis by carbon clea...
Source: Bulletin of Faculty of Pharmacy, Cairo University - September 6, 2017 Category: Drugs & Pharmacology Source Type: research

Impact of pharmacist-led collaborative patient education on medication adherence and quality of life of schizophrenia patients in a tertiary care setting
The objective of study was to assess the impact of pharmacist-led collaborative patient education on medication adherence and QOL in schizophrenia patients in a psychiatry out-patient setting of a tertiary-care setting. Patients were randomized into two groups. Interventional patients received medication review, followed by patient education session using Patient-Information Leaflets (PILs) developed for the study. Control patients received usual-care. Patients data were collected at the beginning of the study and after each follow-up of one-month interval, till 3rd follow-up. Medication adherence and QOL were assessed usi...
Source: Bulletin of Faculty of Pharmacy, Cairo University - August 22, 2017 Category: Drugs & Pharmacology Source Type: research

Antihyperglycemic activity of Caralluma quadrangula in streptozotocin-induced diabetic rats
In conclusion, this study proved the traditional use of C. quadrangula in diabetes mellitus. (Source: Bulletin of Faculty of Pharmacy, Cairo University)
Source: Bulletin of Faculty of Pharmacy, Cairo University - August 3, 2017 Category: Drugs & Pharmacology Source Type: research

Pharmacological and phytochemical studies of Alangium salvifolium Wang. – A review
Publication date: Available online 18 July 2017 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Suresh Shravya, Balakrishnan Nair Vinod, Christudas Sunil Alangium salvifolium has been used traditionally for treatment of various ailments. Almost every part of A. salvifolium including roots, leaves, stem and bark are used in the Ayurveda and Siddha systems of medicines for the treatment of various diseases. In modern scientific literatures, the plant has been reported to have potential efficacy against diabetes, peptic ulcer, arthritis, inflammation and anthelminthic activities etc. A. salvifolium is...
Source: Bulletin of Faculty of Pharmacy, Cairo University - July 19, 2017 Category: Drugs & Pharmacology Source Type: research

Influence of surface charge on the in vitro protein adsorption and cell cytotoxicity of paclitaxel loaded poly( ε-caprolactone) nanoparticles
Publication date: Available online 4 July 2017 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Sathyamoorthy Nandhakumar, Magharla Dasaratha Dhanaraju, Vankayalu Devendran Sundar, Battu Heera The biokinetic fate of polymeric nanoparticles in the physiological milieu is strongly influenced by its properties such as size, surface charge and surface affinity. The electrostatic properties of the polymeric nanoparticles and, thereby, the reliant properties such as cellular interactions, reactivity and toxicity, can be tailored by modulating the surface charge. Therefore, the present study aimed at stud...
Source: Bulletin of Faculty of Pharmacy, Cairo University - July 5, 2017 Category: Drugs & Pharmacology Source Type: research

Effects of different homeopathic potencies of Cephalendra indica in treatment of neuropathic pain in streptozotocin induced diabetes
This study was designed to evaluate the effect of homeopathic preparation of Cephalendra indica (family Cucurbitaceae) mother tincture (MT), 6 C and 30 C potencies on DN in wistar rats. DN was induced by intraperitoneal injection of streptozotocin (60mg/kg) 15min after nicotinamide (230mg/kg, i.p.) administration. Rats were divided into six groups (n=6). Group 1 and 2 were kept normal control and diabetic control respectively whereas groups 3–5 consist of DN rats treated with different doses of C. indica MT, 6 C and 30 C potencies for 30days. Gabapentin (30mg/kg) was used as standard. DN was assessed by thermal (hot plat...
Source: Bulletin of Faculty of Pharmacy, Cairo University - June 28, 2017 Category: Drugs & Pharmacology Source Type: research

Synthesis, characterization and pharmacological evaluation of different 1,3,4-oxadiazole and acetamide derivatives of ethyl nipecotate
Publication date: Available online 24 June 2017 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Khadija Nafeesa, Aziz-ur-Rehman, Muhammad A. Abbasi, Sabahat Z. Siddiqui, Shahid Rasool, Syed A.A. Shah A new series of N-substituted derivatives of 2-[(5-{1-[(4-chlorophenyl)sulfonyl]-3-piperidinyl}-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide (6a-w) has been designed and synthesized with multifunctional moieties. The synthesized compounds were evaluated for their antibacterial and anti-enzymatic potential supported by % hemolytic activity. The synthesized compound 5-(1-(4-chlorophenylsulfonyl)-3-piperidi...
Source: Bulletin of Faculty of Pharmacy, Cairo University - June 25, 2017 Category: Drugs & Pharmacology Source Type: research

Assessment of oxLDL, anti-oxLDL antibodies and lipoprotein-associated phospholipase A2 as cardiovascular risk markers in obese adolescents with and without T1DM
Conclusion The current data provide evidence that oxLDL, its retroactive enzyme and antibody are present in circulation early in childhood when primed by obesity and hyperglycemia in T1DM and suggests that they could be useful markers for cardiovascular diseases (CVD). (Source: Bulletin of Faculty of Pharmacy, Cairo University)
Source: Bulletin of Faculty of Pharmacy, Cairo University - June 2, 2017 Category: Drugs & Pharmacology Source Type: research

Umbelliferone: Sources, chemistry and bioactivities review
Publication date: Available online 23 May 2017 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Ofentse Mazimba Umbelliferone is a 7-hydroxycoumarin that is a pharmacologically active agent. It is widely distributed within the Rutaceae and Apiaceae (Umbelliferae) families and is efficiently extracted using methanol. Umbelliferone is a fluorescing compound used as a sunscreen agent. It is synthesized using the Pechmann condensation reaction of resorcinol and formyl acetic acid. Biosynthetically it is synthesized using the phenylpropanoid pathway. Umbelliferone is a synthon for other coumarins and heter...
Source: Bulletin of Faculty of Pharmacy, Cairo University - May 23, 2017 Category: Drugs & Pharmacology Source Type: research

Development and validation of LC-MS/MS assay for the determination of Butoconazole in human plasma: Evaluation of systemic absorption following topical application in healthy volunteers
Publication date: Available online 6 May 2017 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Eman G. Nouman, Medhat A. Al-Ghobashy, Hayam M. Lotfy Butoconazole is an imidazole antifungal that is more effective than miconazole and clotrimazole for treatment of vaginal candidiasis. A highly sensitive tandem mass spectrometric assay was developed and validated to evaluate systemic absorption of Butoconazole following intravaginal administration. Chromatographic separation was achieved using Waters Xterra C18 column (3µm, 3.0×50.0mm). Liquid-liquid extraction using tert-butyl methyl ether was used f...
Source: Bulletin of Faculty of Pharmacy, Cairo University - May 7, 2017 Category: Drugs & Pharmacology Source Type: research

Protective effect of Emblica officinalis fruit extract on cisplatin-induced nephrotoxicity in female rats
This study was designed to evaluate the protective role of Emblica officinalis against cisplatin induced nephrotoxicity in female rats. Emblica officinalis was orally administered for 10days in 50, 100 and 200mg/kg body weight. On day 7, 8mg/kg of cisplatin was administered intra-peritoneally to rats in all groups. Serum creatinine, blood urea nitrogen and antioxidant levels were measured on day10. The renal damage was evaluated by histopathological, transmission electron microscopy and immunohistochemical analysis. We found that 200mg/kg dose of Emblica officinalis significantly inhibited the elevation of biochemical para...
Source: Bulletin of Faculty of Pharmacy, Cairo University - April 29, 2017 Category: Drugs & Pharmacology Source Type: research

Chromatographic methods for the simultaneous determination of binary mixture of Saxagliptin HCl and Metformin HCl
Publication date: Available online 26 April 2017 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Hanan A. Merey, Nesrin K. Ramadan, Sherine S. Diab, Azza A. Moustafa Two chromatographic methods were suggested for the simultaneous determination of a binary mixture containing Saxagliptin HCl (SAG) and Metformin HCl (MET). First method was RP-HPLC method. Chromatographic separation was done on Kinetex™ column–C18 (4.6×150mm, 2.6µm) using mobile phase consisted of acetonitrile:phosphate buffer pH=4.5 ±0.1 adjusted with orthophosphoric acid (13:87, v/v). Isocratic elution at a flow rate 1.5mL/m...
Source: Bulletin of Faculty of Pharmacy, Cairo University - April 27, 2017 Category: Drugs & Pharmacology Source Type: research

An overview of the genus Prismatomeris: Phytochemistry and biological activity
Publication date: Available online 18 March 2017 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Ninh The Son Genus Prismatomeris belongs to Rubiaceae family, with interesting secondary metabolites, comprising main classes of compounds anthraquinones, iridoids, triterpenoids and their derivative glycoside. Prismatomeris species has been employing as folk medicines against hepatitis, stomachaches, pneumoconiosis, poultice to fresh wounds, bloody vomiting, etc. Many bioactive reports such as cytotoxic assay, antifungal, antimalarial, or oedema inhibitory activity, indicate either Prismatomeris extracts...
Source: Bulletin of Faculty of Pharmacy, Cairo University - March 17, 2017 Category: Drugs & Pharmacology Source Type: research