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Identification of possible Ser/Thr/Tyr phosphorylation sites in the fungal histidine kinase CaNik1p by peptide array technique
In this study, we aimed to identify additional possible P-sites in this HK. Therefore, we constructed a peptide array that covers the full length protein. Incubation of the purified His-tagged CaNik1p with the peptide array in the presence of radioactive ATP [γ-32P] revealed the possible P-sites in each peptide. We classified the peptides according to their intensities. Peptides bearing His510 and D924 showed either null or very weak intensities. The highest intensity was corresponding to the peptide containing the amino acid T994, while lower intensities were related mainly to serine and threonine residues and to lower e...
Source: Bulletin of Faculty of Pharmacy, Cairo University - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Validated determination of diacerein and its active metabolite, rhein, by stability indicating constant pattern method as a novel manipulation of zero order spectra
Publication date: June 2018Source: Bulletin of Faculty of Pharmacy, Cairo University, Volume 56, Issue 1Author(s): Aml A. Emam, Nouruddin W. AliAbstractA novel spectrophotometric method named constant absorbance pattern technique was proposed for simple determination of binary mixtures exemplified by diacerein, a treatment of osteoarthritis, and rhein, diacerein main alkaline degradation product and active metabolite. The proposed novel constant absorbance pattern technique was highly accurate, precise, sensitive, specific and stability indicating as well. The proposed technique allowed determination of diacerein and rhein...
Source: Bulletin of Faculty of Pharmacy, Cairo University - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

In vitro activity of dihydropyrazole derivatives against Candida species
In this study, we investigate the efficacy of different benzodioxolpyrazoline derivatives against two Candida species. All compounds exhibited potent in vitro antifungal activity against both species. Compound 5 showed the best inhibition zone in comparison to positive controls for Candida albicans. For Candida parapsilosis, all the tested compounds were active while the positive controls were inactive. These compounds provide good starting models for the development of new antimicrobial agents which could be useful especially for the treatment of candidiasis. (Source: Bulletin of Faculty of Pharmacy, Cairo University)
Source: Bulletin of Faculty of Pharmacy, Cairo University - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Quinazolino-thiadiazoles as antimicrobial agents
Publication date: June 2018Source: Bulletin of Faculty of Pharmacy, Cairo University, Volume 56, Issue 1Author(s): Harun Patel, Atul Shirkhedkar, Sanjay Bari, Kamalkishor Patil, Amit Arambhi, Chandrakantsing Pardeshi, Abhijeet Kulkarni, Sanjay SuranaAbstractIn the present research, we report the synthesis and in vitro antimicrobial activity of a new series of novel quinazolino-thiadiazoles as fused pharmacophore (3–20). In general, the results of the in vitro antibacterial activity are encouraging, as out of 18 compounds tested, Compounds 3 and 8 with a 4-chlorophenyl and 4-nitro phenyl at C-2 of thiadiazole and chlorome...
Source: Bulletin of Faculty of Pharmacy, Cairo University - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Radical scavenging potential, antiinflammatory and antiarthritic activity of isolated isomer Methyl-γ-Orsellinate and roccellatol from Roccella montagnei Bel
Publication date: June 2018Source: Bulletin of Faculty of Pharmacy, Cairo University, Volume 56, Issue 1Author(s): Syed Zameer Ahmed Khader, Sidhra Syed Zameer Ahmed, Thangakumar Arunachalam, Sanjeeva Nayaka, Senthil Kumar Balasubramanian, Syed Tajudeen SyedAmeen, Ponmurugan PonnusamyAbstractThe burden of multiple drug resistance towards chronic diseases is rapidly increasing globally at an alarm rate. The present study aims to isolate active principles via bioassay guided fractionation of traditionally used lichen Roccella montagnei for in vitro radical scavenging activity with potential to combat arthritis and inflammati...
Source: Bulletin of Faculty of Pharmacy, Cairo University - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

POM analyses, immunomodulatory, cytotoxic activities and polyphenolic constituents of Callistemon viridiflorus fruits
Publication date: Available online 28 June 2018Source: Bulletin of Faculty of Pharmacy, Cairo UniversityAuthor(s): Mohamed I.S. Abdelhady, Amel M. Kamal, Mohamed F. BarghashAbstractPhytochemical study on 80% ethanolic extract of Callistemon viridiflorus Sims fruits (CVF) resulted in isolation of five phenolic compounds 1; Gallic acid, 2; Ellagic acid, 3; Reynoutrin, 4; Methoxy ellagic acid, 5; Quercetin. Petra/Osiris/Molinspiration (POM) analyses predicted that Reynoutrin and Quercetin have interesting potential activities, also Reynoutrin is found to be safer in relation to Quercetin. 80% ethanolic extract of CVF, Reynout...
Source: Bulletin of Faculty of Pharmacy, Cairo University - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Aurones and furoaurones: Biological activities and synthesis
Publication date: Available online 6 July 2018Source: Bulletin of Faculty of Pharmacy, Cairo UniversityAuthor(s): Ghaneya S. Hassan, Hanan H. Georgey, Riham F. George, Eman R. MohamedAbstractAurones, (Z)-2-benzylidenebenzofuran-3(2H)-ones, have proved to be promising bioactive compounds with a broad spectrum of activities including anticancer, antioxidant, antiparasitic and antibacterial activities. Aurones exhibited strong antiproliferative properties against cancer cells by acting on variable targets through different modes of action. Furoaurones, (Z)-2-benzylidenefurano[3,2-f] benzofuran-3(2H)-ones, is a class of semi s...
Source: Bulletin of Faculty of Pharmacy, Cairo University - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Resveratrol pretreatment reduces circulating inflammatory interleukins in CCl4-induced hepatotoxicity rats
In conclusion, RSV has a prophylactic effect against hepatotoxicity induced by CCl4 through decreasing the inflammatory interleukins level. (Source: Bulletin of Faculty of Pharmacy, Cairo University)
Source: Bulletin of Faculty of Pharmacy, Cairo University - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

Impact of pharmacist-led collaborative patient education on medication adherence and quality of life of schizophrenia patients in a tertiary care setting
The objective of study was to assess the impact of pharmacist-led collaborative patient education on medication adherence and QOL in schizophrenia patients in a psychiatry out-patient setting of a tertiary-care setting. Patients were randomized into two groups. Interventional patients received medication review, followed by patient education session using Patient-Information Leaflets (PILs) developed for the study. Control patients received usual-care. Patients data were collected at the beginning of the study and after each follow-up of one-month interval, till 3rd follow-up. Medication adherence and QOL were assessed usi...
Source: Bulletin of Faculty of Pharmacy, Cairo University - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

Synthesis, characterization and pharmacological evaluation of different 1,3,4-oxadiazole and acetamide derivatives of ethyl nipecotate
Publication date: December 2017Source: Bulletin of Faculty of Pharmacy, Cairo University, Volume 55, Issue 2Author(s): Khadija Nafeesa, Aziz-ur-Rehman, Muhammad A. Abbasi, Sabahat Z. Siddiqui, Shahid Rasool, Syed A.A. ShahAbstractA new series of N-substituted derivatives of 2-[(5-{1-[(4-chlorophenyl)sulfonyl]-3-piperidinyl}-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide (6a-w) has been designed and synthesized with multifunctional moieties. The synthesized compounds were evaluated for their antibacterial and anti-enzymatic potential supported by % hemolytic activity. The synthesized compound 5-(1-(4-chlorophenylsulfonyl)-3-piperi...
Source: Bulletin of Faculty of Pharmacy, Cairo University - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

Software based approaches for drug designing and development: A systematic review on commonly used software and its applications
Publication date: December 2017Source: Bulletin of Faculty of Pharmacy, Cairo University, Volume 55, Issue 2Author(s): Prasad G. Jamkhande, Mahavir H. Ghante, Balaji R. AjgundeAbstractDrug discovery include drug designing and development, is a multifarious and expensive endeavor, where least number of drugs that pass the clinical trials makes it to market. Software based drug discovery and development methods have major role in the development of bioactive compounds for over last three decades. Novel software based methods such as molecular modeling, structure-based drug design, structure-based virtual screening, ligand in...
Source: Bulletin of Faculty of Pharmacy, Cairo University - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

Experimental animal models used for evaluation of potential immunomodulators: A mini review
Publication date: December 2017Source: Bulletin of Faculty of Pharmacy, Cairo University, Volume 55, Issue 2Author(s): Aditya Ganeshpurkar, Ajay K. SalujaAbstractPreclinical models of immunomodulatory studies are indispensable part in the process of drug discovery and development. Still, they are mimeo of human immunostimulation/suppression provided heterogeneity of latter. This review discusses various preclinical models of immunomodulatory studies viz. cell lines for immunomodulatory studies, murine models include humoral antibody (HA) response, delayed type hypersensitivity response, macrophage phagocytosis by carbon cl...
Source: Bulletin of Faculty of Pharmacy, Cairo University - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

Pharmacological and phytochemical studies of Alangium salvifolium Wang. – A review
Publication date: December 2017Source: Bulletin of Faculty of Pharmacy, Cairo University, Volume 55, Issue 2Author(s): Suresh Shravya, Balakrishnan Nair Vinod, Christudas SunilAbstractAlangium salvifolium has been used traditionally for treatment of various ailments. Almost every part of A. salvifolium including roots, leaves, stem and bark are used in the Ayurveda and Siddha systems of medicines for the treatment of various diseases. In modern scientific literatures, the plant has been reported to have potential efficacy against diabetes, peptic ulcer, arthritis, inflammation and anthelminthic activities etc. A. salvifoli...
Source: Bulletin of Faculty of Pharmacy, Cairo University - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

Umbelliferone: Sources, chemistry and bioactivities review
Publication date: December 2017Source: Bulletin of Faculty of Pharmacy, Cairo University, Volume 55, Issue 2Author(s): Ofentse MazimbaAbstractUmbelliferone is a 7-hydroxycoumarin that is a pharmacologically active agent. It is widely distributed within the Rutaceae and Apiaceae (Umbelliferae) families and is efficiently extracted using methanol. Umbelliferone is a fluorescing compound used as a sunscreen agent. It is synthesized using the Pechmann condensation reaction of resorcinol and formyl acetic acid. Biosynthetically it is synthesized using the phenylpropanoid pathway. Umbelliferone is a synthon for other coumarins a...
Source: Bulletin of Faculty of Pharmacy, Cairo University - July 5, 2018 Category: Drugs & Pharmacology Source Type: research