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Pharmacophore mapping: Prediction of BCR–ABL kinase inhibitory activity of α-benzylthio chalcones
Publication date: June 2014 Source:Bulletin of Faculty of Pharmacy, Cairo University, Volume 52, Issue 1 Author(s): Richa Bajaj , Vikas Sharma , Vipin Kumar In this investigation, 3D pharmacophore modeling studies were performed on a diverse set of 33 α-benzylthio chalcone derivatives that demonstrate anticancer activity by blocking BCR–ABL phosphorylation in leukemic cells. Pharmacophore modeling is based on the principle of the alignment of pharmacophoric features which has been carried out on the same set of molecules. Five point pharmacophores with one negative ionizable group, one hydrophobic group and three...
Source: Bulletin of Faculty of Pharmacy, Cairo University - October 13, 2014 Category: Drugs & Pharmacology Source Type: research

Chromatographic determination of clopidogrel bisulfate; detection and quantification of counterfeit Plavix® tablets
Publication date: June 2014 Source:Bulletin of Faculty of Pharmacy, Cairo University, Volume 52, Issue 1 Author(s): Mona E. ElTantawy , Lories I. Bebawy , Rafeek F. Shokry Counterfeiting of pharmaceutical products is a global problem. Upon using quality-ensuring methods of international pharmacopoeias, additional impurities and the low content of the active pharmaceutical ingredients were detected. In this paper, two chromatographic HPLC and TLC-densitometric methods were proposed as fast and reliable methods for detection and quantitation of counterfeit Plavix® tablets. These tablets were chemically counterfeited ...
Source: Bulletin of Faculty of Pharmacy, Cairo University - October 13, 2014 Category: Drugs & Pharmacology Source Type: research

Validated stability-indicating HPLC-DAD method for determination of the phosphodiesterase (PDE-4) inhibitor roflumilast
Publication date: June 2014 Source:Bulletin of Faculty of Pharmacy, Cairo University, Volume 52, Issue 1 Author(s): Tarek S. Belal , Hytham M. Ahmed , Mohamed S. Mahrous , Hoda G. Daabees , Mostafa M. Baker A comprehensive stability indicating HPLC with diode array detection method was developed for determination of the recently approved phosphodiesterase type 4 (PDE-4) inhibitor roflumilast (RFL). Effective chromatographic separation was achieved using Durashell C18 column (4.6×250mm, 5μm particle size) with isocratic elution of the mobile phase composed of 0.0065M ammonium acetate pH 6.3, methanol and acetonit...
Source: Bulletin of Faculty of Pharmacy, Cairo University - October 13, 2014 Category: Drugs & Pharmacology Source Type: research

Electrophoretic behavior of charge regulated zwitter ionic buffers in covalently and dynamically coated fused silica capillaries
Publication date: June 2014 Source:Bulletin of Faculty of Pharmacy, Cairo University, Volume 52, Issue 1 Author(s): Medhat A. Al-Ghobashy In this work, the electrophoretic behavior of zwitterionic buffers is investigated in the absence of electroosmotic flow (EOF). Electro mobilization of capillary contents is noted when zwitterionic buffers are employed as the background electrolyte at a pH where the buffering moiety carries a net charge. The bulk flow of capillary contents was demonstrated via monitoring the migration of a neutral marker as well as a free and micellar negatively charged marker and SDS–protein comp...
Source: Bulletin of Faculty of Pharmacy, Cairo University - October 13, 2014 Category: Drugs & Pharmacology Source Type: research

Validated spectrophotometric methods for the evaluation of Oseltamivir counterfeit pharmaceutical capsules
Publication date: June 2014 Source:Bulletin of Faculty of Pharmacy, Cairo University, Volume 52, Issue 1 Author(s): Rasha M. Youssef , Fawzi A. El-Yazbi , Essam F. Khamis , Sameh E. Younis Four rapid, reliable and economical spectrophotometric methods have been established for the quantitative determination of Oseltamivir phosphate (OST) without the interference of ascorbic acid (ASC) found in some of its counterfeit capsules. The first method involves the use of derivative spectrophotometry with the zero-crossing technique where OST was easily determined using its 1D (Δλ =3) at 219nm. The second method is based ...
Source: Bulletin of Faculty of Pharmacy, Cairo University - October 13, 2014 Category: Drugs & Pharmacology Source Type: research

Effect of biphenyl dimethyl dicarboxylate and fluoxetine on performance of normally-fed and protein malnourished psychologically stressed mice in elevated plus maze
Publication date: June 2014 Source:Bulletin of Faculty of Pharmacy, Cairo University, Volume 52, Issue 1 Author(s): M.F. Sabry , M.R. Hamed , M.E. El sayed Stress alters psychological diseases such as anxiety and depression. Protein malnutrition (PM) contributes to psychological disorders. The present study aimed to investigate the effect of biphenyl dimethyl dicarboxylate (DDB) on anxiety of psychologically stressed protein malnourished mice as compared to its effect in normally-fed mice. Fluoxetine (FLX) was used as reference standard. Animals were randomly divided into two major groups, normally-fed group provide...
Source: Bulletin of Faculty of Pharmacy, Cairo University - October 13, 2014 Category: Drugs & Pharmacology Source Type: research

Protective effects of ursodeoxycholic acid on ceftriaxone-induced hepatic injury in rats
In this study, our aim was to investigate the use of ursodeoxycholic acid (UDCA) in prevention of the hepatotoxic effect and biochemical changes induced by ceftriaxone in rats. Rats were divided into six groups (control, UDCA 20mg/kg, ceftriaxone 180mg/kg, UDCA+ceftriaxone 180mg/kg, ceftriaxone 360mg/kg, and UDCA+ceftriaxone 360mg/kg). Ceftriaxone was injected intraperitoneally, and UDCA was given orally daily for four consecutive weeks. Then liver functions (serums AST, ALT, ALP, direct bilirubin, and total protein) were assessed. Histopathological examination was performed. Treatment of animals with ceftriaxone caused el...
Source: Bulletin of Faculty of Pharmacy, Cairo University - October 13, 2014 Category: Drugs & Pharmacology Source Type: research

Therapeutic potential of hydroxychloroquine on serum B-cell activating factor belonging to the tumor necrosis factor family (BAFF) in rheumatoid arthritis patients
Conclusion Elevated level of BAFF in RA has been confirmed with a notable relation to disease activity making it a promising marker. The beneficial effect of hydroxychloroquine in dampening BAFF level throws light on the importance of considering it in combination among the newly developed biologics that also target B-cells. (Source: Bulletin of Faculty of Pharmacy, Cairo University)
Source: Bulletin of Faculty of Pharmacy, Cairo University - October 13, 2014 Category: Drugs & Pharmacology Source Type: research

Modulatory role of chelating agents in diet-induced hypercholesterolemia in rats
Conclusion Pretreatment of hypercholesterolemic rats with simvastatin, CaNa2EDTA or DMSA attenuated most of the changes induced by feeding rats with cholesterol-rich diet owing to their observed anti-hyperlipidemic and antioxidant properties. (Source: Bulletin of Faculty of Pharmacy, Cairo University)
Source: Bulletin of Faculty of Pharmacy, Cairo University - October 13, 2014 Category: Drugs & Pharmacology Source Type: research

Naringenin protects against scopolamine-induced dementia in rats
Conclusions The observed anti-amnestic effect of naringenin makes it a promising candidate for clinical trials in patients with cognitive impairment. (Source: Bulletin of Faculty of Pharmacy, Cairo University)
Source: Bulletin of Faculty of Pharmacy, Cairo University - October 13, 2014 Category: Drugs & Pharmacology Source Type: research

Chemical constituents, anti-inflammatory, and antioxidant activities of Anisotes trisulcus
Publication date: June 2014 Source:Bulletin of Faculty of Pharmacy, Cairo University, Volume 52, Issue 1 Author(s): Mohamed A. El-Shanawany , Hanaa M. Sayed , Sabrin R.M. Ibrahim , Marwa A.A. Fayed Anisotes trisulcus (Forssk.) Nees. (family Acanthaceae) aerial part is used in folk medicine in the Arabian peninsula for treatment of hepatic conditions. It showed different activities such as antibacterial, hepatoprotective, and cytotoxicity. It is a rich source of alkaloids and is used as an antidiabetic, bronchodilator, hypotensive, and local anesthetic. To the best of our knowledge, there is no report on the phenol...
Source: Bulletin of Faculty of Pharmacy, Cairo University - October 13, 2014 Category: Drugs & Pharmacology Source Type: research

Antihyperglycemic and antihyperlipidemic effects of the methanol extracts of Cleome ramosissima Parl., Barleria bispinosa (Forssk.) Vahl. and Tribulus macropterus Boiss.
Publication date: June 2014 Source:Bulletin of Faculty of Pharmacy, Cairo University, Volume 52, Issue 1 Author(s): Shahira M. Ezzat , Essam Abdel-Sattar , Fathalla M. Harraz , Salah A. Ghareib The antihyperglycemic and antihyperlipidemic effects of the methanolic extracts of the aerial parts of Cleome ramosissima Parl. (Cleomaceae), Barleria bispinosa (Forssk.) Vahl. (Acanthaceae) and Tribulus macropterus Boiss. (Zygophyllaceae) were evaluated in streptozotocin (STZ) induced diabetic rats at a dose of 500mg/kgbw. The reduction in fasting blood glucose level (BGL) was observed in the following order C. ramosissima,...
Source: Bulletin of Faculty of Pharmacy, Cairo University - October 13, 2014 Category: Drugs & Pharmacology Source Type: research

Natural anti-obesity agents
Publication date: Available online 14 June 2014 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Gamal A. Mohamed , Sabrin R.M. Ibrahim , Ehab S. Elkhayat , Riham Salah El Dine Obesity is a complex disease caused by the interaction of a myriad of genetic, dietary, lifestyle, and environmental factors, which favors a chronic positive energy balance, and leads to increased body fat mass. The incidence of obesity is rising at an alarming rate and is becoming a major public health concern with incalculable social costs. Indeed, obesity facilitates the development of metabolic disorders such as diabet...
Source: Bulletin of Faculty of Pharmacy, Cairo University - October 13, 2014 Category: Drugs & Pharmacology Source Type: research

Chemical constituents and biological investigations of the aerial parts of Egyptian Clerodendrum inerme
Publication date: Available online 20 June 2014 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Sabrin R.M. Ibrahim , Khalid Z. Alshali , Mostafa A. Fouad , Ehab S. Elkhayat , Rwaida A. Al Haidari , Gamal A. Mohamed B-friedoolean-5-ene-3-β-ol (1), β-sitosterol (2), stigmasta-5,22,25-trien-3-β-ol (3), betulinic acid (4), and 5-hydroxy-6,7,4′-trimethoxyflavone (5) were isolated from the aerial parts of Clerodendrum inerme L. (Verbenaceae). Their structures were established based on analyses of physical and spectroscopic data. Compounds 1, 4, and 5 were isolated for the first time from the p...
Source: Bulletin of Faculty of Pharmacy, Cairo University - October 13, 2014 Category: Drugs & Pharmacology Source Type: research

Beneficial effects of thymoquinone and omega-3 on intestinal ischemia/reperfusion-induced renal dysfunction in rats
This study is to investigate the possible beneficial effects of thymoquinone and omega-3 separately in II/R-induced renal dysfunction in rats. Sixty-four Wistar albino rats were randomly allocated into four experimental groups namely sham control, II/R control, thymoquinone and omega-3 each group pre-treated separately. II/R model was established by clamping the superior mesenteric artery (SMA) for 30min followed by 60min reperfusion. Serum level of creatinine was measured. Renal tissue contents of malodialdehyde (MDA) and reduced glutathione (GSH) as well as myeloperoxidase (MPO), tumor necrosis factor alpha (TNF-α) and ...
Source: Bulletin of Faculty of Pharmacy, Cairo University - October 13, 2014 Category: Drugs & Pharmacology Source Type: research