Bulletin of Faculty of Pharmacy, Cairo University This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Validated chromatographic methods for the simultaneous determination of Mometasone furoate and Formoterol fumarate dihydrate in a combined dosage form
Publication date: Available online 17 February 2016 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Hanan A. Merey, Sally S. El-Mosallamy, Nagiba Y. Hassan, Badr A. El-Zeany Two chromatographic methods were developed and validated for the simultaneous determination of Mometasone furoate (MO) and Formoterol fumarate dihydrate (FOR). Combination of MO and FOR is used for the treatment of asthma in patients suffering from reversible obstructive airway disease. The first chromatographic method was based on using aluminum TLC plates pre-coated with silica gel GF254 as the stationary phase and chl...
Source: Bulletin of Faculty of Pharmacy, Cairo University - February 19, 2016 Category: Drugs & Pharmacology Source Type: research

Facile synthesis, spectral characterization, antimicrobial and in vitro cytotoxicity of novel N3,N5-diisonicotinyl-2,6-dimethyl-4-phenyl-1,4-dihydropyridine-3,5-dicarbohydrazide derivatives
Publication date: Available online 10 February 2016 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Karthikeyan Elumalai, Manogaran Elumalai, Kalpana Eluri, Sivaneswari Srinivasan, Mohamed Ashraf Ali, Basu Venkateswara Reddy, Sarada Prasad Sarangi A new series of some novel isoniazid condensed 1,4-dihydropyridines was prepared by reaction of N-(3-oxobutanoyl) isonicotinohydrazide with aryl aldehyde and 25–30% ammonia solution in the presence of catalytic amount of barium nitrate as an efficient catalyst. The confirmation of the chemical structure of the synthesized compounds (4a–m)...
Source: Bulletin of Faculty of Pharmacy, Cairo University - February 10, 2016 Category: Drugs & Pharmacology Source Type: research

Biological activities of leaves of ethnomedicinal plant, Borassus flabellifer Linn. (Palmyra palm): An antibacterial, antifungal and antioxidant evaluation
Publication date: Available online 3 February 2016 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Prasad G. Jamkhande, Vikas A. Suryawanshi, Tukaram M. Kaylankar, Shailesh L. Patwekar Plants contain a variety of phytochemicals that have the ability to exert effect on human body. Among them Borassus flabellifer Linn. is a medicinally important plant. In traditional medicine different parts of plants are being used for their medicinal properties. The methanol extract was obtained from powdered leaves and further fractions were prepared. Antimicrobial potential was investigated using eight pat...
Source: Bulletin of Faculty of Pharmacy, Cairo University - February 4, 2016 Category: Drugs & Pharmacology Source Type: research

Simultaneous determination of Carbazochrome and Troxerutin in their binary mixture by HPLC and HPTLC-Densitometric methods
Publication date: Available online 25 January 2016 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Maha Mohamed Abdelrahman, Eglal Abdelhameed Abdelaleem, Nouruddin Wageih Ali, Raghda Abdelmoneim Emam Two accurate, precise and sensitive RP-HPLC and HPTLC-Densitometric methods have been developed for the determination of Carbazochrome and Troxerutin in their binary mixture without previous separation. Method (A) is RP-HPLC which depended on isocratic elution using C18 column and mobile phase consisting of water containing (0.2% triethylamine (TEA), 1% tetrahydrofuran (THF)):methanol (65:35, b...
Source: Bulletin of Faculty of Pharmacy, Cairo University - January 27, 2016 Category: Drugs & Pharmacology Source Type: research

Comparative study on four spectrophotometric methods manipulating ratio spectra for the simultaneous determination of binary mixture of diflucortolone valerate and isoconazole nitrate
Publication date: Available online 14 January 2016 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Yasmine M. Fayez, Mohamed R. Elghobashy, Zeinab M. Goda, Mostafa A. Shehata Four simple, accurate, reproducible and non-sophisticated spectrophotometric methods manipulating ratio spectra were developed and validated for the simultaneous determination of diflucortolone valerate (DIF) and isoconazole nitrate (ISO) without preliminary separation in pure powder form and in their cream formulation. Method A, is constant center spectrophotometric method (CC), method B is a ratio difference spectroph...
Source: Bulletin of Faculty of Pharmacy, Cairo University - January 15, 2016 Category: Drugs & Pharmacology Source Type: research

HPLC and TLC chromatographic methods for simultaneous determination of binary mixture of isoconazole nitrate and diflucortolone valerate
Publication date: Available online 12 January 2016 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Mohamed R. El-Ghobashy, Yasmin M. Fayez, Zeinab M. Goda, Mostafa A. Shehata HPLC and TLC-densitometric methods were used to determine a binary mixture of isoconazole (ISO) and diflucortolone (DIF). For HPLC method a rapid separation could be achieved on a C18 column using mobile phase of 80% acetonitrile–20% methanol. The components were monitored at 230nm over a concentration range of 10–90μgmL−1 for ISO and 2–18μgmL−1 for DIF with mean percentage recoveries 99.95±0.866 and 99.98Â...
Source: Bulletin of Faculty of Pharmacy, Cairo University - January 13, 2016 Category: Drugs & Pharmacology Source Type: research

Spectrophotometric determination of the sulfhydryl containing drug mesna
Publication date: Available online 31 December 2015 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Rim S. Haggag, Dina A. Gawad, Saeid F. Belal, Hadil M. Elbardisy Four simple and sensitive spectrophotometric methods were developed for the determination of the sulfhydryl containing drug mesna (MSN). Methods I and II rely on nucleophilic aromatic substitution reactions using two UV tagging reagents namely: 4-chloro-7-nitrobenzo-2-oxa-1,3-diazole (NBD-Cl) for method I and 2,4-dinitrofluorobenzene (DNFB) for method II. Both reactions took place in alkaline buffered medium and the obtained yell...
Source: Bulletin of Faculty of Pharmacy, Cairo University - January 11, 2016 Category: Drugs & Pharmacology Source Type: research

Black seed oil ameliorated scopolamine-induced memory dysfunction and cortico-hippocampal neural alterations in male Wistar rats
This study was conducted to evaluate cognitive enhancing effect and ameliorative effects of black seed oil in scopolamine induced rat model of cognitive impairment. These effects were investigated on scopolamine-induced dementia model in Morris water maze test (MWM) and Y maze test. The hippocampal histoarchitectural responses to scopolamine and Nigella sativa oil were also examined. Scopolamine (1mg/kgip) was given to induce dementia, followed by oral administration of BSO (1ml/kg) for 14 consecutive days. MWM and Y-maze paradigms were used to assess hippocampal and frontal dependent memory respectively, thereafter the ra...
Source: Bulletin of Faculty of Pharmacy, Cairo University - January 11, 2016 Category: Drugs & Pharmacology Source Type: research

Diflucortolone valerate loaded solid lipid nanoparticles as a semisolid topical delivery system
Publication date: Available online 23 December 2015 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Fatma S. Abdel-Salam, Seham A. Elkheshen, Azza A. Mahmoud, Hussein O. Ammar Solid lipid nanoparticles (SLNs) are promising delivery carriers that have been utilized for formulation and delivery of various drugs. For topical administration, they are usually incorporated into gel or cream to increase their residence time, which is time-consuming process and could affect their stability and characteristics. Preparation of solid lipid nanoparticles based semisolid formulations could have potential...
Source: Bulletin of Faculty of Pharmacy, Cairo University - December 23, 2015 Category: Drugs & Pharmacology Source Type: research

Folic acid restores endothelial function in ACTH-induced hypertension
Publication date: Available online 18 December 2015 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Ibrahim Elmadbouh, Mahmoud Elodemi, Mohamed Nabih, Safa Elfiky, Adel Omar Hypertension is associated with increased oxidative stress and vascular endothelium dysfunction. The aim was to study the effect of folic acid (FA) on hypertension, blood nitric oxide (NO), homocysteine (HCY), malondialdehyde (MDA) and reduced glutathione (GSH); aortic tissue glutathione peroxidase (GPx), catalase (CAT), superoxide dismutase (SOD); and vascular endothelial function in adrenocorticotrophic hormone (ACTH...
Source: Bulletin of Faculty of Pharmacy, Cairo University - December 19, 2015 Category: Drugs & Pharmacology Source Type: research

Comparative DNA profiling, botanical identification and biological evaluation of Gazania longiscapa DC and Gazania rigens L.
Publication date: December 2015 Source:Bulletin of Faculty of Pharmacy, Cairo University, Volume 53, Issue 2 Author(s): Wafaa M. El Kady, Abeer A.A. Salama, Samar Y. Desoukey, Eman G. Hagag, Siham M. El-Shenawy, M.A. El-Shanawany Gazania longiscapa DC and Gazania rigens L. are species of cultivated ornamental plant that grow in Egypt. Genus Gazania has a role in folk medicine to prevent toothache; this study presents a comparative investigation of genetic and botanical features of root, rhizome, leaves and flowers of the two Gazania species and comparing their biological activity as analgesic and antiinfla...
Source: Bulletin of Faculty of Pharmacy, Cairo University - November 28, 2015 Category: Drugs & Pharmacology Source Type: research

Cytotoxicity and antioxidant activity of new biologically active constituents from Micromeria nervosa grown in Egypt
Publication date: Available online 19 November 2015 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Mohammed F. Abdelwahab, Mohammed H. Hussein, Hazem H. Kadry Chromatographic fractionation of the acetone extract of Micromeria nervosa, resulted in the isolation and identification of new natural furanosesquiterpene alcohol; micromeriol (1), a known sterol; β-sitosterol (2), a new natural 5-β-cholestane type; nervosane (3), two known triterpenic acids; oleanolic acid (4), and ursolic acid (5). The cytotoxicity and the antioxidant activities of the acetone extract and the isolated pure compound...
Source: Bulletin of Faculty of Pharmacy, Cairo University - November 22, 2015 Category: Drugs & Pharmacology Source Type: research

A review on controlled porosity osmotic pump tablets and its evaluation
Publication date: Available online 3 November 2015 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Chinmaya Keshari Sahoo, Nalini Kanta Sahoo, Surepalli Ram Mohan Rao, Muvvala Sudhakar, Kokkula Satyanarayana Conventional drug delivery system provides an immediate release of drug which does not control the release of the drug and does not maintain effective concentration at target site for a longer period of time. Hence to avoid the shortcomings there is development of various controlled drug delivery systems. Among these osmotic drug delivery system (ODDS) utilizes the principle of osmotic...
Source: Bulletin of Faculty of Pharmacy, Cairo University - November 5, 2015 Category: Drugs & Pharmacology Source Type: research

Univariate spectrophotometry and multivariate calibration: Stability-indicating analytical tools for the quantification of pimozide in bulk and pharmaceutical dosage form
Publication date: Available online 27 October 2015 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Amal Mahmoud Abou Al Alamein, Lobna Abd El Aziz Hussien, Ekram Hany Mohamed Simple, accurate sensitive and precise spectrophotometric and chemometric stability indicating techniques were adopted for the determination of Pimozide (PIM) in presence of its alkaline and acidic degradation products over a concentration range of 10–100μgmL−1. The proposed spectrophotometric technique includes first derivative (D1) spectrophotometric one at 252nm and 256.6nm in presence of its acidic and alkaline d...
Source: Bulletin of Faculty of Pharmacy, Cairo University - October 29, 2015 Category: Drugs & Pharmacology Source Type: research

Nanostructured lipid carrier system for topical delivery of Terbinafine Hydrochloride
Publication date: Available online 29 October 2015 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Bharti Gaba, Mohammad Fazil, Saba Khan, Asgar Ali, Sanjula Baboota, Javed Ali The main aim of the present study was to develop and evaluate Terbinafine HCl (TH)-loaded nanostructured lipid carrier (NLC) for the treatment of fungal infection via topical administration. Fungal infections are tremendously widespread and the treatments are effective but associated toxicities restrict their use. TH-NLC was prepared using high pressure homogenization technique using Glyceryl Monostearate (GMS) as...
Source: Bulletin of Faculty of Pharmacy, Cairo University - October 29, 2015 Category: Drugs & Pharmacology Source Type: research