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Enhancement of antibacterial activity of ciprofloxacin hydrochloride by complexation with sodium cholate
This study showed that development of hydrophobic ion pair complex enhances antibacterial activity of ciprofloxacin hydrochloride. (Source: Bulletin of Faculty of Pharmacy, Cairo University)
Source: Bulletin of Faculty of Pharmacy, Cairo University - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

Formulation of risperidone loaded proniosomes for effective transdermal delivery: An in-vitro and in-vivo study
Publication date: December 2017Source: Bulletin of Faculty of Pharmacy, Cairo University, Volume 55, Issue 2Author(s): Sharda Sambhakar, Sarvesh Paliwal, Swapnil Sharma, Bishambar SinghAbstractIn the present investigation, proniosomes of risperidone were formulated, optimized and evaluated for effective transdermal delivery in order to overcome the bioavailability issues of orally administered risperidone. The proniosomes were prepared using various sorbitan esters with cholesterol and soya lecithin and were evaluated for in-vitro parameters, ex-vivo permeation and in-vivo performance. Results indicated that the vesicles w...
Source: Bulletin of Faculty of Pharmacy, Cairo University - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

Chromatographic methods for the simultaneous determination of binary mixture of Saxagliptin HCl and Metformin HCl
Publication date: December 2017Source: Bulletin of Faculty of Pharmacy, Cairo University, Volume 55, Issue 2Author(s): Hanan A. Merey, Nesrin K. Ramadan, Sherine S. Diab, Azza A. MoustafaAbstractTwo chromatographic methods were suggested for the simultaneous determination of a binary mixture containing Saxagliptin HCl (SAG) and Metformin HCl (MET). First method was RP-HPLC method. Chromatographic separation was done on Kinetex™ column–C18 (4.6 × 150 mm, 2.6 µm) using mobile phase consisted of acetonitrile:phosphate buffer pH = 4.5 ± 0.1 adjusted with orthophosphoric acid (13:87, v...
Source: Bulletin of Faculty of Pharmacy, Cairo University - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

Effect of myricetin on the transgenic Drosophila model of Parkinson’s disease
Publication date: December 2017Source: Bulletin of Faculty of Pharmacy, Cairo University, Volume 55, Issue 2Author(s): Gulshan Ara, Mohammad Afzal, Smita Jyoti, Yasir Hasan SiddiqueAbstractParkinson’s disease (PD) is a progressive neurodegenerative disorder that affects movement, balance and fine motor control mostly in the elderly population. It is characterized by the progressive loss of neurons in substantia nigra resulting in the depletion of dopamine. Due to ethical reasons the study cannot be performed directly on humans, hence various genetic models of PD based on alpha synuclein, primarily the transgenic over exp...
Source: Bulletin of Faculty of Pharmacy, Cairo University - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

Acute and subchronic toxicity evaluation of methanol stem-bark extract of Ximenia americana Linn (Olacaceae) in Wistar rats
In conclusion, acute oral administration of methanol stem-bark extract of Ximenia americana was relatively non-toxic in mice, but minimal anatomical changes in kidney, lungs and spleen occurred when used for few weeks in rats. (Source: Bulletin of Faculty of Pharmacy, Cairo University)
Source: Bulletin of Faculty of Pharmacy, Cairo University - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

Antihyperglycemic activity of Caralluma quadrangula in streptozotocin-induced diabetic rats
In conclusion, this study proved the traditional use of C. quadrangula in diabetes mellitus. (Source: Bulletin of Faculty of Pharmacy, Cairo University)
Source: Bulletin of Faculty of Pharmacy, Cairo University - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

Effects of different homeopathic potencies of Cephalendra indica in treatment of neuropathic pain in streptozotocin induced diabetes
This study was designed to evaluate the effect of homeopathic preparation of Cephalendra indica (family Cucurbitaceae) mother tincture (MT), 6 C and 30 C potencies on DN in wistar rats. DN was induced by intraperitoneal injection of streptozotocin (60 mg/kg) 15 min after nicotinamide (230 mg/kg, i.p.) administration. Rats were divided into six groups (n = 6). Group 1 and 2 were kept normal control and diabetic control respectively whereas groups 3–5 consist of DN rats treated with different doses of C. indica MT, 6 C and 30 C potencies for 30 days. Gabapentin (30 mg/kg) was used as stan...
Source: Bulletin of Faculty of Pharmacy, Cairo University - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

TLC-densitometric and first derivative spectrophotometric methods for determination of cefoxitin-sodium in presence of its alkali-induced degradation product
Publication date: December 2017Source: Bulletin of Faculty of Pharmacy, Cairo University, Volume 55, Issue 2Author(s): Khalid Abdel-Salam M. Attia, Omar Abdel-Aziz, Nancy Magdy, Ghada F. MohamedAbstractTwo simple and accurate methods were developed for quantitative estimation of cefoxitin sodium in presence of its open ring alkali-induced degradation product. The first method was based on TLC separation of the drug from its alkali-induced degradation product followed by densitometric measurement of the intact drug at 254 nm. The proposed method obeys Beer’s law in range (1–20 µg/band). The second method was ...
Source: Bulletin of Faculty of Pharmacy, Cairo University - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

Improved predictions of nonlinear support vector regression and artificial neural network models via preprocessing of data with orthogonal projection to latent structures: A case study
Publication date: December 2017Source: Bulletin of Faculty of Pharmacy, Cairo University, Volume 55, Issue 2Author(s): Ibrahim A. NaguibAbstractIn the presented study, orthogonal projection to latent structures (OPLS) is introduced as a data preprocessing method that handles nonlinear data prior to modelling with two well established nonlinear multivariate models; namely support vector regression (SVR) and artificial neural networks (ANN). The proposed preprocessing proved to significantly improve prediction abilities through removal of uncorrelated data.The study was established based on a case study nonlinear spectr...
Source: Bulletin of Faculty of Pharmacy, Cairo University - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

Multivariate optimization for simultaneous determination of aspirin and simvastatin by reverse phase liquid chromatographic method using AQbD approach
Publication date: December 2017Source: Bulletin of Faculty of Pharmacy, Cairo University, Volume 55, Issue 2Author(s): Kalpana G. Patel, Apeksha T. Patel, Purvi A. Shah, Tejal R. GandhiAbstractThe present study describes the development of a robust method for the separation of aspirin and simvastatin using reverse phase high performance liquid chromatographic method on Kintex reverse phase C18 column (5 μm, 250 mm × 4.6 mm) with UV detection at 234 nm. Box-Behnken design was applied for multivariate optimization of the experimental conditions of RP-HPLC for obtaining desired chromatographic ...
Source: Bulletin of Faculty of Pharmacy, Cairo University - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

Development and validation of LC-MS/MS assay for the determination of Butoconazole in human plasma: Evaluation of systemic absorption following topical application in healthy volunteers
Publication date: December 2017Source: Bulletin of Faculty of Pharmacy, Cairo University, Volume 55, Issue 2Author(s): Eman G. Nouman, Medhat A. Al-Ghobashy, Hayam M. LotfyAbstractButoconazole is an imidazole antifungal that is more effective than miconazole and clotrimazole for treatment of vaginal candidiasis. A highly sensitive tandem mass spectrometric assay was developed and validated to evaluate systemic absorption of Butoconazole following intravaginal administration. Chromatographic separation was achieved using Waters Xterra C18 column (3 µm, 3.0 × 50.0 mm). Liquid-liquid extraction using ter...
Source: Bulletin of Faculty of Pharmacy, Cairo University - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

Assessment of oxLDL, anti-oxLDL antibodies and lipoprotein-associated phospholipase A2 as cardiovascular risk markers in obese adolescents with and without T1DM
ConclusionThe current data provide evidence that oxLDL, its retroactive enzyme and antibody are present in circulation early in childhood when primed by obesity and hyperglycemia in T1DM and suggests that they could be useful markers for cardiovascular diseases (CVD). (Source: Bulletin of Faculty of Pharmacy, Cairo University)
Source: Bulletin of Faculty of Pharmacy, Cairo University - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

Influence of surface charge on the in vitro protein adsorption and cell cytotoxicity of paclitaxel loaded poly(ε-caprolactone) nanoparticles
Publication date: December 2017Source: Bulletin of Faculty of Pharmacy, Cairo University, Volume 55, Issue 2Author(s): Sathyamoorthy Nandhakumar, Magharla Dasaratha Dhanaraju, Vankayalu Devendran Sundar, Battu HeeraAbstractThe biokinetic fate of polymeric nanoparticles in the physiological milieu is strongly influenced by its properties such as size, surface charge and surface affinity. The electrostatic properties of the polymeric nanoparticles and, thereby, the reliant properties such as cellular interactions, reactivity and toxicity, can be tailored by modulating the surface charge. Therefore, the present study aimed at...
Source: Bulletin of Faculty of Pharmacy, Cairo University - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

Formulation optimization and evaluation of fast dissolving film of aprepitant by using design of experiment
Publication date: Available online 7 May 2018Source: Bulletin of Faculty of Pharmacy, Cairo UniversityAuthor(s): Rajni Bala, Shailesh Sharma, IKGPTUAbstractThe concept of fast dissolving dosage form has become popular as new delivery system. This system will provide maximum therapeutic efficacy, increased bioavailability and maximum stability by reducing the frequency of dosage. It will also avoid first pass metabolism of the drugs. This system provides more rapid drug absorption from the pre gastric area which may provide quick onset of action. The present research aimed to prepare fast dissolving films (FDF) of aprepitan...
Source: Bulletin of Faculty of Pharmacy, Cairo University - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

Evaluation of the physician’s acceptance to clinical pharmacy interventions after antibiotic stewardship implementation in the ICU in a general hospital in Egypt
ConclusionThe physicians in Al-Haram hospital appeared to accept the role of clinical pharmacist in correcting antibiotic-related DRPs as well as in implementing ASP. (Source: Bulletin of Faculty of Pharmacy, Cairo University)
Source: Bulletin of Faculty of Pharmacy, Cairo University - July 5, 2018 Category: Drugs & Pharmacology Source Type: research