Bulletin of Faculty of Pharmacy, Cairo University This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

A validated HPTLC method for the quantification of friedelin in Putranjiva roxburghii Wall extracts and in polyherbal formulations
Publication date: Available online 23 November 2016 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Kedar Kalyani Abhimanyu, Chaudhari Sanjay Ravindra, Rao Srinivasa Avanapu In present study HPTLC method was developed and validated for the determination of friedelin in Putranjiva roxburghii Wall (family: Euphorbiaceae) leaf, bark extract and in polyherbal formulations. Analysis of samples were performed on TLC aluminium precoated plate (60 F254) by using mobile phase toluene: chloroform (9:1v/v). Plate was derivatized with vanillin sulphuric acid and scanned at 580nm. Developed method found to give...
Source: Bulletin of Faculty of Pharmacy, Cairo University - November 22, 2016 Category: Drugs & Pharmacology Source Type: research

Pyrrolidine dithiocarbamate ameliorates rotenone-induced Parkinson ’s disease in rats
Publication date: Available online 22 November 2016 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Noha F. Abdelkader, Nadia M. Arafa, Amina S. Attia, Afaf A. Ain-Shoka, Dalaal M. Abdallah Pyrrolidine dithiocarbamate (PDTC), a low-molecular-weight thiol antioxidant, possesses neuroprotection; however, its possible modulatory effect in Parkinson’s disease (PD) has not been tested. Male Wistar rats were injected with rotenone to induce PD-like symptoms. Histopathological findings showed that striatal neurons were degenerated following rotenone administration, an effect that was accompanied by be...
Source: Bulletin of Faculty of Pharmacy, Cairo University - November 21, 2016 Category: Drugs & Pharmacology Source Type: research

Application of membrane-selective electrodes for the determination of Tiemonium methylsulphate
Publication date: Available online 9 November 2016 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Lobna A. Hussein Three ion selective electrodes were developed for the quantification of Tiemonium methylsulphate (TIM). Two of these sensors involve the construction of water insoluble ion-association complexes; namely sensor1 TIM-phosphotungstate (TIM-PT) and sensor 2 TIM-Reinecke (TIM-R). Molecular recognition elements have extensive applications in electrochemical sensors with a significant potential for future development thus a third electrode utilizing molecularly imprinted polymer was constructe...
Source: Bulletin of Faculty of Pharmacy, Cairo University - November 8, 2016 Category: Drugs & Pharmacology Source Type: research

Antihyperlipidemic effect of Ficus dalhousiae miq. stem bark on Triton WR-1339 and high fat diet-induced hyperlipidemic rats
Publication date: Available online 3 November 2016 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Surendran Surya, Ravindrakurup Arun Kumar, Betty Carla, Christudas Sunil Ficus dalhousiae stem bark is used to treat cancer and hyperlipidemia in folklore practices. F. dalhousiae stem bark methanolic extract (250 and 500mg/kgb. wt.) was evaluated for antihyperlipidemic activity in Triton WR-1339 and high fat diet-induced hyperlipidemic rats. F. dalhousiae extract significantly (P ⩽ 0.005) alter the serum TC, TG, LDL-C and HDL-C levels to near normal in Triton WR-1339 and high fat diet-induced hype...
Source: Bulletin of Faculty of Pharmacy, Cairo University - November 3, 2016 Category: Drugs & Pharmacology Source Type: research

Quercetin nanoparticles attenuates scopolamine induced spatial memory deficits and pathological damages in rats
Publication date: Available online 31 October 2016 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Suresh Palle, Prasad Neerati Quercetin is a well-known flavonoid, has low bioavailability. Quercetin nanoparticles (NQC) enhance its bioavailability. NQC were not explored for their potential therapeutic activities in Alzheimer’s disease (AD). Hence, the present study was performed to evaluate the protective effect of NQC in comparison to free quercetin against scopolamine induced spatial memory impairments. NQC prepared by anti solvent precipitation method. Quercetin, NQC (30mg/kg p.o.) and rivastig...
Source: Bulletin of Faculty of Pharmacy, Cairo University - October 31, 2016 Category: Drugs & Pharmacology Source Type: research

Development of validated HPLC-UV method for simultaneous determination of Metformin, Amlodipine, Glibenclamide and Atorvastatin in human plasma and application to protein binding studies
Publication date: Available online 27 October 2016 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Pawan K. Porwal, Gokul S. Talele A simple, sensitive, fast, and economical HPLC method was developed and validated for simultaneous estimation of two fixed dose combinations frequently prescribed in diabetes (Metformin plus Glibenclamide) and hypertension with dyslipidemia (Amlodipine plus Atorvastatin) in Human plasma for the first time. The validated HPLC method was used to quantify the concentration of selected actives in ultrafiltrate. Optimum separation conditions were obtained with Water’s Nova...
Source: Bulletin of Faculty of Pharmacy, Cairo University - October 28, 2016 Category: Drugs & Pharmacology Source Type: research

A statistical study on the development of micro particulate sustained drug delivery system for Losartan potassium by 32 factorial design approach
Publication date: Available online 27 October 2016 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Gokul Khairnar, Jitendra Naik, Vinod Mokale The purpose of this study was to investigate the effect of polymer and surfactant concentration on drug loading and in vitro drug release of micro particulate drug delivery system of Losartan potassium (LST). Microparticles were prepared by O/O solvent emulsification method. A 32 full factorial design was used to derive statistical equation and construct contour plots to predict responses. The independent variables selected were polymer concentration (A), su...
Source: Bulletin of Faculty of Pharmacy, Cairo University - October 28, 2016 Category: Drugs & Pharmacology Source Type: research

Hypoglycemic effects of Berberis aristata and Tamarindus indica extracts in vitro
Conclusion The results of the study verified the hypoglycemic activity of the extracts of B. aristata and T. indica. However, the observed effects need to be confirmed using different in vivo models and clinical trials for their effective utilization as therapeutic agents. (Source: Bulletin of Faculty of Pharmacy, Cairo University)
Source: Bulletin of Faculty of Pharmacy, Cairo University - October 20, 2016 Category: Drugs & Pharmacology Source Type: research

Neuroprotective effects of potassium channel openers on cerebral ischemia –reperfusion injury in diabetic rats
Conclusion Treatment of ischemic stroke with potassium channel openers in T1DR is neuroprotective. Inhibition of apoptosis may contribute to their neuroprotective effects after stroke in T1DR. (Source: Bulletin of Faculty of Pharmacy, Cairo University)
Source: Bulletin of Faculty of Pharmacy, Cairo University - October 20, 2016 Category: Drugs & Pharmacology Source Type: research

Pyridoacridine alkaloids from deep-water marine organisms: Structural elucidation
Publication date: Available online 22 September 2016 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Sabrin R.M. Ibrahim, Gamal A. Mohamed Pyridoacridine alkaloids are unique marine nitrogenous compounds that represent a large family of alkaloids. They have been reported from different marine organisms like sponges, ascidians, anemones, prosobranch mollusk, and tunicates. Attention to pyridoacridines has risen because of their significant biological activities. The present review emphasizes mainly on pyridoacridines isolated marine organisms over the last years. Thus, the synthetic ones were not dis...
Source: Bulletin of Faculty of Pharmacy, Cairo University - September 22, 2016 Category: Drugs & Pharmacology Source Type: research

Synthesis, characterization and antimicrobial evaluation of some novel quinoline derivatives bearing different heterocyclic moieties
Publication date: Available online 28 August 2016 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Kamal M. El-Gamal, Mohamed S. Hagrs, Hamada S. Abulkhair A series of 3-substituted 6-methoxy-1H-pyrazolo [3,4-b]quinoline derivatives was synthesized by treating 6-methoxy-1H-pyrazolo[3,4-b]quinolin-3-amine (6) with different acid anhydrides including succinic anhydride, maleic anhydride and phthalic anhydride. Also, a series of 3-heteroaryl-2-chloro-6-methoxyquinolines was prepared through 1,3-dipolar cycloaddition of different bi-nucleophiles including hydrazine hydrate, hydroxylamine hydrochloride, ...
Source: Bulletin of Faculty of Pharmacy, Cairo University - August 27, 2016 Category: Drugs & Pharmacology Source Type: research

Investigation of using robust statistics: Weighted, parametric & amp; non parametric linear regression of derivative/discrete Fourier transform HPLC convoluted peak responses for handling standard addition method data in bioanalysis
Publication date: Available online 23 August 2016 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Mohamed A. Korany, Heba H. Abdine, Marwa A.A. Ragab, Sara I. Aborass Errors that may be encountered during the use of standard addition method (SAM), especially in the estimation of low drug concentrations in biological fluids, are overcome by the combination of chemometric treatment of data along with the application of weighted regression (WR) as a robust statistic method. The study compares the effect of combining different chemometric and statistical methods of regression in handling data of the S...
Source: Bulletin of Faculty of Pharmacy, Cairo University - August 23, 2016 Category: Drugs & Pharmacology Source Type: research

Chemical constituents from Gazania linearis cultivated in Egypt
Publication date: Available online 18 August 2016 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Ehab Saad Elkhayat Chemical investigation of the cytotoxic n-hexane fraction of the rhizomes of Gazania linearis (Thunb.) Druce (Asteraceae), led to isolation of a steroid-glucoside and three triterpenes, together with three sesquiterpene lactones. The chemical structures of the isolated compounds were established based on their spectroscopic analyses (IR, 1D and 2D NMR, and mass spectroscopy) to be: lupeol-3-O-stearate (1), costunolide (2), 11,13-dihydro-costunolide (3), santamarine (4), in addition to ...
Source: Bulletin of Faculty of Pharmacy, Cairo University - August 18, 2016 Category: Drugs & Pharmacology Source Type: research

Egyptian Pancratium maritimum L. flowers as a source of anti-Alzheimer ’s agents
Publication date: June 2015 Source:Bulletin of Faculty of Pharmacy, Cairo University, Volume 53, Issue 1 Author(s): Maha Mohamed Soltan, Ahmed R. Hamed, Mona H. Hetta, Ahmed A. Hussein Elevation of acetylcholinesterase enzyme (AChE) has been reported to be implicated in the etiology of Alzheimer disease (AD). One of the encouraged strategies to fight AD is the plant-derived inhibitors. Amaryllidaceae species are enriched source of alkaloids. The inhibitory properties of roots and bulbs of Pancratium maritimum L. against AChE have been previously reported. In the present study, the flowers of the wild Egyptian P...
Source: Bulletin of Faculty of Pharmacy, Cairo University - July 20, 2016 Category: Drugs & Pharmacology Source Type: research

LC –MS/MS based-comparative study of (S)-nicotine metabolism by microorganisms, mushroom and plant cultures: Parallels to its mammalian metabolic fate
Publication date: December 2015 Source:Bulletin of Faculty of Pharmacy, Cairo University, Volume 53, Issue 2 Author(s): Amira R. Khattab, Abdel-Rahim S. Ibrahim, Souzan M. Ibrahim, Kamillia A. Abou El-Seoud, Wafaa E. Soliman, Fathy K. El-Fiky The metabolic fate of nicotine using the cell cultures of microorganisms, mushroom and plants was explored using LC–MS/MS analysis. The study demonstrated parallels to phase I mammalian metabolism of nicotine and reported that nicotine was biotransformed into its N-oxide by Streptomyces fradiae culture. Moreover, it was metabolized in Pleurotus ostreatus culture into...
Source: Bulletin of Faculty of Pharmacy, Cairo University - July 20, 2016 Category: Drugs & Pharmacology Source Type: research