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Synthesis of some new 5-substituted-2-((6-chloro-3,4-methylenedioxyphenyl)methylthio)-1,3,4-Oxadiazole derivatives as suitable antibacterial inhibitors
Publication date: Available online 12 November 2014 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Aziz-ur-Rehman , Asia Siddiqa , Muhammad A. Abbasi , Shahid Rasool , Sabahat Z. Siddiqui , Irshad Ahmad , Saira Afzal Heterocyclic molecules belong to the most attractive group owing to their broad spectrum of antimicrobial activities. In the undertaken research, a number of new 5-substituted-2-((6-chloro-3,4-methylenedioxyphenyl)methylthio)-1,3,4-Oxadiazole derivatives (6a – l) were synthesized by converting various aryl/aralkyl carboxylic acids (1 a–l) into corresponding esters (2 a–l), ...
Source: Bulletin of Faculty of Pharmacy, Cairo University - November 13, 2014 Category: Drugs & Pharmacology Source Type: research

Hypoglycemic potential of alcoholic root extract of Cassia occidentalis Linn. in streptozotocin induced diabetes in albino mice
Conclusion The results suggest that ethanolic roots extract of C. occidentalis Linn. possesses hypoglycemic potential for the NIDDM and support the traditional use of the roots of plant as hypoglycemic agent. (Source: Bulletin of Faculty of Pharmacy, Cairo University)
Source: Bulletin of Faculty of Pharmacy, Cairo University - November 9, 2014 Category: Drugs & Pharmacology Source Type: research

Biotransformation of Furanocoumarins by Cunninghamella elegans
Publication date: Available online 6 November 2014 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Ghada Ismail El-shahat Ali Attia , Kamillia A. Abou-El-seoud , Abdel-Rahim Sayed Ibrahim Biotransformation of Furanocoumarins; psoralen (1), bergapten (2), xanthotoxin (3) and imperatorin (4) was explored by Cunninghamella elegans NRRL 1392, revealing the metabolism of psoralen (1) and bergapten (2) into bergaptol (5), while xanthotoxin (3) and imperatorin (4) were converted into xanthotoxol (6). On the other hand unexpected conversion of xanthotoxin (3) into 3,4 dihydroxanthotoxin (7) occurred. The...
Source: Bulletin of Faculty of Pharmacy, Cairo University - November 9, 2014 Category: Drugs & Pharmacology Source Type: research

Interaction of glimepiride with prokinetic drugs on some of gastrointestinal functions in STZ-induced diabetic mice
Conclusion Use of metoclopramide, domperidone or erythromycin with glimepiride may guard against the risk of gastrointestinal motility disturbance associated with glimepiride treated diabetic patients and may enhance the absorption of carbohydrates. The dose of glimepiride may be safely decreased when combined with erythromycin or metoclopramide. (Source: Bulletin of Faculty of Pharmacy, Cairo University)
Source: Bulletin of Faculty of Pharmacy, Cairo University - October 13, 2014 Category: Drugs & Pharmacology Source Type: research

Beneficial effects of co-enzyme Q10 and rosiglitazone in fructose-induced metabolic syndrome in rats
In conclusion, the present study proves the benefits of co-supplementation of CoQ and Rosi in a fructose-induced model of insulin resistance. (Source: Bulletin of Faculty of Pharmacy, Cairo University)
Source: Bulletin of Faculty of Pharmacy, Cairo University - October 13, 2014 Category: Drugs & Pharmacology Source Type: research

Beneficial effects of Aloe vera in treatment of diabetes: Comparative in vivo and in vitro studies
Publication date: June 2013 Source:Bulletin of Faculty of Pharmacy, Cairo University, Volume 51, Issue 1 Author(s): Amira Mourad Hussein Abo-Youssef , Basim Anwar Shehata Messiha In the present investigation, the antidiabetic effect of Aloe vera leaf pulp extract was studied in vivo and in vitro as compared to glimiperide. Diabetes was induced experimentally in adult male albino rats by single-dose intraperitoneal injection of streptozotocin (50mg/kg body weight). The in vitro study was performed using isolated islets of pancreas from adult female albino rats. Both aloe extract (10ml/kg, p.o.) and glimiperide (10mg/k...
Source: Bulletin of Faculty of Pharmacy, Cairo University - October 13, 2014 Category: Drugs & Pharmacology Source Type: research

Bioactivity-guided fractionation of the stem bark extract of Pterocarpus dalbergioides Roxb. ex Dc growing in Egypt
Publication date: June 2013 Source:Bulletin of Faculty of Pharmacy, Cairo University, Volume 51, Issue 1 Author(s): Camilia Michel , Moshera El-sherei , Wafaa Islam , Amani Sleem , Shaimaa Ahmed A bioactivity-guided investigation of the ethanolic extract (70%) of the stem bark of Pterocarpus dalbergioides Roxb. ex DC revealed that the butanol fraction possessed potent antihyperglycemic and anti-inflammatory activities at a dose of 100mg/kg b.wt. compared to metformin (150mg/kg b.wt.) and indomethacin (20mg/kg b.wt.) respectively. Two phenolic acids viz: gentisic (1) and gallic (3) acids and isoflavone genistin (2)...
Source: Bulletin of Faculty of Pharmacy, Cairo University - October 13, 2014 Category: Drugs & Pharmacology Source Type: research

Tapentadol, a novel analgesic: Review of recent trends in synthesis, related substances, analytical methods, pharmacodynamics and pharmacokinetics
Publication date: December 2013 Source:Bulletin of Faculty of Pharmacy, Cairo University, Volume 51, Issue 2 Author(s): Deepti Jain , Pawan Kumar Basniwal This write-up describes the comprehensive facts of tapentadol, on recent trends in synthesis, related substances, analytical methods, pharmacodynamics, pharmacokinetics, adverse effect and drug interaction. Chemically, tapentadol is 3-[(1R,2R)-3-(dimethylamino)-1-ethyl-2-methylpropyl] phenol hydrochloride. Tapentadol is a centrally-acting synthetic novel analgesic which acts as μ-opioid receptor agonist as well as norepinephrine re-uptake inhibitor. Nausea and vom...
Source: Bulletin of Faculty of Pharmacy, Cairo University - October 13, 2014 Category: Drugs & Pharmacology Source Type: research

Synthesis and antitumor activity of certain 2,3,6-trisubstituted quinazolin-4(3H)-one derivatives
Publication date: December 2013 Source:Bulletin of Faculty of Pharmacy, Cairo University, Volume 51, Issue 2 Author(s): Safinaz E. Abbas , Flora F. Barsoum , Hanan H. Georgey , Eman R. Mohammed The synthesis of different series of 6-iodo-2-phenoxymethyl 3-substituted quinazolin-4(3H)-ones 5–17 is described. The structures of the newly synthesized compounds have been confirmed on the basis of elemental analyses, IR, 1H NMR and mass spectral data. Preliminary testing for the in vitro antitumor activity of the synthesized compounds against MCF-7 breast cell line was carried out using Doxorubicin (IC50: 5.46μmol/ml)...
Source: Bulletin of Faculty of Pharmacy, Cairo University - October 13, 2014 Category: Drugs & Pharmacology Source Type: research

Preparation and in vitro evaluation of rutin nanostructured liquisolid delivery system
Conclusion: The optimized liquisolid dosage form of rutin provided good flowability as well as fast drug release properties and, therefore, can be suitable for oral delivery system. (Source: Bulletin of Faculty of Pharmacy, Cairo University)
Source: Bulletin of Faculty of Pharmacy, Cairo University - October 13, 2014 Category: Drugs & Pharmacology Source Type: research

Determination of insecticides malathion and lambda-cyhalothrin residues in zucchini by gas chromatography
Publication date: December 2013 Source:Bulletin of Faculty of Pharmacy, Cairo University, Volume 51, Issue 2 Author(s): Hayam M. Lofty , Abd El-Aziz A. Abd El-Aleem , Hany H. Monir A sensitive gas chromatographic method has been developed for the determination of malathion and lambda-cyhalothrin (λ-cyhalothrin) insecticide residues in zucchini. The developed method consists of extraction with acetone, purification and partitioning with methylene chloride, column chromatographic clean-up, and finally capillary gas chromatographic determination of the insecticides. The recoveries of method were greater than 90% and l...
Source: Bulletin of Faculty of Pharmacy, Cairo University - October 13, 2014 Category: Drugs & Pharmacology Source Type: research

Formulation consideration and characterization of microemulsion drug delivery system for transnasal administration of carbamazepine
Publication date: December 2013 Source:Bulletin of Faculty of Pharmacy, Cairo University, Volume 51, Issue 2 Author(s): Rashmin B. Patel , Mrunali R. Patel , Kashyap K. Bhatt , Bharat G. Patel The purpose of the present study was to formulate and characterize carbamazepine loaded microemulsion and mucoadhesive microemulsion drug delivery system for its intranasal administration. Carbamazepine microemulsion and mucoadhesive microemulsion were prepared by titration method. The drug-loaded microemulsions were successfully prepared which contain 6% Labrafil M 1944 CS as an oily phase, 32% surfactant mixture of Cremopho...
Source: Bulletin of Faculty of Pharmacy, Cairo University - October 13, 2014 Category: Drugs & Pharmacology Source Type: research

Validated stability-indicating high performance thin layer chromatographic method for determination of Ivabradine hydrochloride in bulk and marketed formulation: An application to kinetic study
Publication date: December 2013 Source:Bulletin of Faculty of Pharmacy, Cairo University, Volume 51, Issue 2 Author(s): Mitesh H. Motisariya , Kalpana Govindbhai Patel , Purvi A. Shah A sensitive, selective, precise and accurate stability-indicating high-performance thin layer chromatographic method for analysis of Ivabradine hydrochloride (IH) an anti anginal agent, both as a bulk drug and in formulations was developed and validated according to ICH guideline. Densitometric analysis of IH was carried out in the absorbance mode at 287nm using ethyl acetate: 0.389M ammonium acetate in methanol (1:5, v/v) as solvent s...
Source: Bulletin of Faculty of Pharmacy, Cairo University - October 13, 2014 Category: Drugs & Pharmacology Source Type: research

Sagitol C, a new cytotoxic pyridoacridine alkaloid from the sponge Oceanapia sp.
Publication date: December 2013 Source:Bulletin of Faculty of Pharmacy, Cairo University, Volume 51, Issue 2 Author(s): Sabrin R.M. Ibrahim , Gamal A. Mohamed , Ehab S. Elkhayat , Mostafa A. Fouad , Peter Proksch A new pyridoacridine alkaloid named sagitol C (2) together with two known compounds; kuanoniamine C (1) and sagitol (3) were isolated from the EtOAc fraction of the Indonesian sponge Oceanapia sp. Their chemical structures were established on the basis of physical and spectroscopic methods 1D and 2D NMR, in addition to mass spectrometry and comparison with literature data. Sagitol C was found to exhibit c...
Source: Bulletin of Faculty of Pharmacy, Cairo University - October 13, 2014 Category: Drugs & Pharmacology Source Type: research

Renoprotective effect of aliskiren monotherapy and aliskiren−pentoxifylline combination in hypertensive-diabetic type 2 patients with diabetic nephropathy
Conclusion Aliskiren monotherapy and aliskiren−pentoxifylline combination improved kidney function among hypertensive-diabetic type 2 patients with DN, however, aliskiren−pentoxifylline combination had a better renoprotective effect. (Source: Bulletin of Faculty of Pharmacy, Cairo University)
Source: Bulletin of Faculty of Pharmacy, Cairo University - October 13, 2014 Category: Drugs & Pharmacology Source Type: research