Bulletin of Faculty of Pharmacy, Cairo University 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Anti-fertility and abortifacient potential of hydroalcoholic leaves extract of Alstonia scholaris in female rats: An ethnomedicine used by Papua women in New Guinea
Conclusions HAAS possesses anti-fertility effect due to the inhibition of implantation and estrogenic effect which in turn might be due to the presence of active phytoconstituents in the plant. (Source: Bulletin of Faculty of Pharmacy, Cairo University)
Source: Bulletin of Faculty of Pharmacy, Cairo University - March 16, 2017 Category: Drugs & Pharmacology Source Type: research
Different spectrophotometric and TLC-densitometric methods for determination of pyrazinamide in presence of its impurity
Publication date: Available online 15 March 2017 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Neven Magdy Habib, Nourudin Wagih Ali, Nada Sayed Abdelwhab, Maha Mohamed Abdelrahman In this search, three selective spectrophotometric and TLC-densitometric methods have been developed and validated for quantitative determination of Pyrazinamide (PYN) and its impurity, Pyrazine-2-carboxylic acid (PYA). The proposed methods are third derivative spectrophotometric (Method I), first derivative of ratio spectra spectrophotometric (Method II), mean centering of ratio spectra spectrophotometric (MCR) (Meth...
Source: Bulletin of Faculty of Pharmacy, Cairo University - March 16, 2017 Category: Drugs & Pharmacology Source Type: research
Antifungal and cytotoxic constituents from the endophytic fungus Penicillium sp.
Publication date: Available online 9 March 2017 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Ehab S. Elkhayat, Asmaa Mohamed Goda New mellein derivative; 4-methylmellein (1) along with five known compounds: 4-hydroxymellein (2) and 6-hydroxymellein (3), tyrosol (4), cervesterol (5), and stigmast-4-ene-3-one (6) were isolated from the ethyl acetate extract of the endophytic fungus Penicillium sp. isolated from the leaf of Senecio flavus (Asteraceae). Structures were established by 1D and 2D NMR, in addition to UV, IR and MS spectrometry. Compounds (3, 4 and 6) were isolated for the first time from...
Source: Bulletin of Faculty of Pharmacy, Cairo University - March 9, 2017 Category: Drugs & Pharmacology Source Type: research
Evaluating the potential cancer chemopreventive efficacy of two different solvent extracts of Seriphidium herba-alba in vitro
Conclusion: both extracts may be cancer chemopreventive agents since they had tumor anti-initiating, and anti-promoting activity. (Source: Bulletin of Faculty of Pharmacy, Cairo University)
Source: Bulletin of Faculty of Pharmacy, Cairo University - March 9, 2017 Category: Drugs & Pharmacology Source Type: research
Novel expandable gastro retentive system by unfolding mechanism of levetiracetam using simple lattice design – Formulation optimization and in vitro evaluation
Publication date: Available online 6 March 2017 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): S. Sivaneswari, E. Karthikeyan, P.J. Chandana The aim of the present study was to develop and characterize a novel expandable gastro-retentive dosage form (GRDF), based on unfolding mechanism. The dosage form consists of a drug loaded the polymeric patch, folded into a hard gelatin capsule. Gastro retention obtained from unfolding and swelling of the patch and its adhesion to the gastric mucosa. Therefore in this work, a gastro retentive patch of levetiracetam was developed using simple lattice design co...
Source: Bulletin of Faculty of Pharmacy, Cairo University - March 7, 2017 Category: Drugs & Pharmacology Source Type: research
Utility of picric acid and 2,4 dinitrophenol as chromogenic reagents for visible spectrophotometric quantification of alogliptin
Publication date: Available online 1 March 2017 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): A.V.V.N.K. Sunil Kumar, T.V. Reddy, C.B. Sekharan Two simple and sensitive visible spectrophotometric methods (A and B) were developed for the determination of alogliptin in bulk and in its tablet dosage forms. The methods use the reaction of alogliptin with picric acid (method A) or 2,4 dinitrophenol (method B) in the chloroform medium. The complex of alogliptin with picric acid (method A) or 2,4 dinitrophenol (method B) showed λmax at 415nm and 430nm respectively. The different conditions affecting th...
Source: Bulletin of Faculty of Pharmacy, Cairo University - February 28, 2017 Category: Drugs & Pharmacology Source Type: research
Simultaneous estimation of Ofloxacin and Cefixime in tablet form in presence of the inactive Ofloxacin USP Related compound A
Publication date: Available online 21 February 2017 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Lobna A. Hussein, Emad M. Hussien, N. Magdy, Heba S. Mohamed A sensitive, precise and simple HPLC method have been developed, optimized and validated for the determination of Ofloxacin and Cefixime in presence of the inactive Ofloxacin USP Related compound A. Ofloxacin Related compound A is stated to be inactive thus its presence in the preparation will affect its potency. An isocratic separation was achieved using hypersil BDS C18 column with flow rate of 0.8mLmin−1 and UV detection at 294nm. The...
Source: Bulletin of Faculty of Pharmacy, Cairo University - February 21, 2017 Category: Drugs & Pharmacology Source Type: research
Dissolution enhancement of leflunomide incorporating self emulsifying drug delivery systems and liquisolid concepts
The objective of this study is to enhance the dissolution properties of leflunomide, a class BCS-II drug by incorporating the self emulsifying (SE) form of the drug onto liquisolid systems in the form of tablets. Different formulae were prepared by dissolving leflunomide in PEG300 then forming SE systems using tween 80 as surfactant and either sesame oil and paraffin oil then adsorbing on powder excipients to form SE liquisolid powders. The prepared powders showed adequate flowability. The drug and excipients showed compatibility by analysis with DSC, XRD and FTIR. After compression, all tablets showed adequate weight vari...
Source: Bulletin of Faculty of Pharmacy, Cairo University - February 7, 2017 Category: Drugs & Pharmacology Source Type: research
Simultaneous determination of Dimenhydrinate, Cinnarizine and Cinnarizine impurity by TLC and HPLC chromatographic methods
Publication date: Available online 30 January 2017 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Amal B. Ahmed, Nada S. Abdelwahab, Maha M. Abdelrahman, Fathy M. Salama Two chromatographic methods have been established and validated for simultaneous determination of mixture of Dimenhydrinate (DMH) and Cinnarizine (CIN) in their pharmaceutical formulation and in presence of Cinnarizine impurity (1-(Diphenylmethyl) piperazine); CIN impurity. The first method was TLC-densitometric one, depends on separation and quantitation of DMH, CIN and CIN impurity on TLC silica gel 60 F254 plates, using chloro...
Source: Bulletin of Faculty of Pharmacy, Cairo University - January 30, 2017 Category: Drugs & Pharmacology Source Type: research
Fabrication and characterization of film-forming voriconazole transdermal spray for the treatment of fungal infection
Publication date: Available online 27 January 2017 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Nitin Merubhai Mori, Priya Patel, Navin R. Sheth, Lalji V. Rathod, Kalpesh Chhotalal Ashara Voriconazole is second-generation triazole used for the treatment of fungal infections but has serious unwanted adverse effects, which could be reduced by topical semisolid dosage form. Major drawbacks of topical semisolid products are poor patient compliance, cross contamination; gels are easily rubbed off by clothing and during day-to-day activities, physical instability. The purpose of the present work was...
Source: Bulletin of Faculty of Pharmacy, Cairo University - January 27, 2017 Category: Drugs & Pharmacology Source Type: research
Adsorption behavior of some metal ions on nanoparticles used in pharmaceutical matrices: Application to laboratory made drug formulation
Publication date: Available online 27 January 2017 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Marwa A.A. Ragab, Mohamed A. Korany, Hesham Z. Ibrahim, Mervat A. Abdel-Kawi, Abd El Aal A.A. Sayed The adsorption behavior of some metal ions (Pb, Mn, Mg, Zn and Ca) was studied on silicon dioxide nanoparticles, SiO2 NP, alone and its mixture with microcrystalline cellulose, MCC, powder (1:1) as drug carriers in pharmaceutical preparations. The effect of different conditions as temperature and pH on adsorption was investigated. It was found that upon increasing the temperature, the ability of the a...
Source: Bulletin of Faculty of Pharmacy, Cairo University - January 27, 2017 Category: Drugs & Pharmacology Source Type: research
Physicochemical, thermodynamic and analytical studies on binary and ternary inclusion complexes of bosentan with hydroxypropyl- β-cyclodextrin
Publication date: Available online 28 December 2016 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Priyanka Jadhav, Yogesh Pore The interactions of poorly aqueous soluble endothelin receptor antagonist bosentan (BOS) with hydroxypropyl-β-cyclodextrin (HPβCD) were assessed in presence and absence of an amino acid l-arginine (ARG), to improve its physicochemical properties. Initially, the phase solubility studies conducted in distilled water followed by thermodynamic investigations demonstrated an AL type of solubility profile and an enthalpy driven exothermic complexation process, respectively, in...
Source: Bulletin of Faculty of Pharmacy, Cairo University - December 28, 2016 Category: Drugs & Pharmacology Source Type: research
Exploring preclinical and clinical effectiveness of nanoformulations in the treatment of atopic dermatitis: Safety aspects and patent reviews
Publication date: Available online 21 December 2016 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Nida Akhtar, Anurag Verma, Kamla Pathak Atopic dermatitis (AD) is the most prevalent chronic disease that affects the skin and is featured by inflammation of the skin. Treatment of AD is entirely focused on to limit the itching, skin repairing as well as reducing the inflammation whenever required. A number of therapeutic agents are available for the treatment of AD. However, topical delivery to the skin has been a consistent challenge for researchers, because of the barrier nature of skin. The prese...
Source: Bulletin of Faculty of Pharmacy, Cairo University - December 21, 2016 Category: Drugs & Pharmacology Source Type: research
Quercetin, ascorbic acid, caffeine and ellagic acid are more efficient than rosiglitazone, metformin and glimepiride in interfering with pathways leading to the development of neurological complications associated with diabetes: A comparative in-vitro study
In conclusion, currently available marketed anti-diabetic drugs have minimal effect on the pathways leading to diabetic neuropathy and supplementing diabetic therapeutics with quercetin, ascorbic acid, caffeine and ellagic acid may be better suited to counter diabetic neuropathy through inhibiting oxidative stress, genotoxicity and improving neuronal glucose utilization. Graphical abstract (Source: Bulletin of Faculty of Pharmacy, Cairo University)
Source: Bulletin of Faculty of Pharmacy, Cairo University - December 17, 2016 Category: Drugs & Pharmacology Source Type: research
Formulation design and optimization of novel fast dissolving tablet of chlorpheniramine maleate by using lyophilization techniques
Publication date: Available online 18 December 2016 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Vivek Dave, Renu Bala Yadav, Richa Ahuja, Sachdev Yadav Fast dissolving tablets (FDTs) have received more interest in the pharmaceutical industry for those categories of drug which show slow dissolution and less oral bioavailability. Nowadays various technologies have been developed for FDTs with improved patient compliance and convenience. FDTs tablets provide an advantage particularly for the pediatric and geriatric patients who have difficulty in swallowing and also for that who are travelling fo...
Source: Bulletin of Faculty of Pharmacy, Cairo University - December 17, 2016 Category: Drugs & Pharmacology Source Type: research
