Adsorption behavior of some metal ions on nanoparticles used in pharmaceutical matrices: Application to laboratory made drug formulation

Publication date: Available online 27 January 2017 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Marwa A.A. Ragab, Mohamed A. Korany, Hesham Z. Ibrahim, Mervat A. Abdel-Kawi, Abd El Aal A.A. Sayed The adsorption behavior of some metal ions (Pb, Mn, Mg, Zn and Ca) was studied on silicon dioxide nanoparticles, SiO2 NP, alone and its mixture with microcrystalline cellulose, MCC, powder (1:1) as drug carriers in pharmaceutical preparations. The effect of different conditions as temperature and pH on adsorption was investigated. It was found that upon increasing the temperature, the ability of the adsorbent material increases. The pH of the metal solution has the same effect as temperature till pH 8. However, above pH 8 the adsorbent material began to lose its adsorption efficiency. Although, the use of SiO2 NP mixture with MCC powder can improve the excipient functionality, it is important to take into consideration their metal adsorption behavior. The study was applied on laboratory made drug formulation contains different drug carriers. The study points at the importance of adjusting the permissible level of metals in different active and inactive ingredients used in pharmaceutical preparations containing nanoparticles as drug carriers. The type of nanoparticles used and the pH of these preparations are important factors affecting the metal adsorption behavior. At the maximum temperature of adsorption, the calculated metal adsorption capacity of a m...
Source: Bulletin of Faculty of Pharmacy, Cairo University - Category: Drugs & Pharmacology Source Type: research