Fabrication and characterization of film-forming voriconazole transdermal spray for the treatment of fungal infection

Publication date: Available online 27 January 2017 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Nitin Merubhai Mori, Priya Patel, Navin R. Sheth, Lalji V. Rathod, Kalpesh Chhotalal Ashara Voriconazole is second-generation triazole used for the treatment of fungal infections but has serious unwanted adverse effects, which could be reduced by topical semisolid dosage form. Major drawbacks of topical semisolid products are poor patient compliance, cross contamination; gels are easily rubbed off by clothing and during day-to-day activities, physical instability. The purpose of the present work was to fabricate 0.5%w/w voriconazole transdermal spray for fungal infection. The transdermal spray was generated by using a film forming polymers like Eudragit RLPO and ethyl cellulose (1:2 ratios) along with eutectic camphor: menthol (1:1) mixture used as a penetration enhancer. The formulation optimized by constrained 32 factorial design. Regression analysis and response surface methodology were used to optimize the effect of polymers and formulate checkpoint batch based on overlay plots. The transdermal spray was subjected to evaluate parameters related to formulation and containers. The concentration of Eudragit RLPO and ethyl cellulose was showed influence on viscosity as well as t50. Diffusion study was showed 75% of voriconazole transport with 65.8μgcm−2 h−1 fluxes. Penetration enhancers’ had shown an increase in 1.68 fold of the penetration of v...
Source: Bulletin of Faculty of Pharmacy, Cairo University - Category: Drugs & Pharmacology Source Type: research