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Quality risk management during pharmaceutical ‘good distribution practices’ – A plausible solution
This study addresses the gap in literature on quality risk management during supply chain operations. There are cases of unresolved customer complaints and batch failures originated due to inadequacies during distribution of pharmaceutical products. In absence of established quality risk management system during product shipment, there is no effective preventive plan related to risk factors. A corollary of manufacturing quality risk management has been drawn to the distribution of pharmaceutical products through this study. The quality risk management during pharmaceutical distribution may be useful to avoid market complai...
Source: Bulletin of Faculty of Pharmacy, Cairo University - December 22, 2017 Category: Drugs & Pharmacology Source Type: research

Notes on the genus Paramignya: Phytochemistry and biological activity
Publication date: Available online 12 December 2017 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Ninh The Son Genus Paramignya belongs to Rutaceae family, with interesting secondary metabolites, comprising main classes of compounds coumarin and coumarin glycosides, acridone alkaloids, tirucallane and tirucallane glycosides, phenols, and flavonoids, as well as several compounds limonoid, lignin glycoside and sterol. Paramignya species has been employing as folk medicines against hepatitis, diabetes, cancer, nose infections. Many bioactive reported such as cytotoxic assay, antioxidant, antiinflammat...
Source: Bulletin of Faculty of Pharmacy, Cairo University - December 12, 2017 Category: Drugs & Pharmacology Source Type: research

Resveratrol pretreatment reduces circulating inflammatory interleukins in CCl4-induced hepatotoxicity rats
In conclusion, RSV has a prophylactic effect against hepatotoxicity induced by CCl4 through decreasing the inflammatory interleukins level. (Source: Bulletin of Faculty of Pharmacy, Cairo University)
Source: Bulletin of Faculty of Pharmacy, Cairo University - December 1, 2017 Category: Drugs & Pharmacology Source Type: research

Validated determination of diacerein and its active metabolite, rhein, by stability indicating constant pattern method as a novel manipulation of zero order spectra
Publication date: Available online 27 November 2017 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Aml A. Emam, Nouruddin W. Ali A novel spectrophotometric method named constant absorbance pattern technique was proposed for simple determination of binary mixtures exemplified by diacerein, a treatment of osteoarthritis, and rhein, diacerein main alkaline degradation product and active metabolite. The proposed novel constant absorbance pattern technique was highly accurate, precise, sensitive, specific and stability indicating as well. The proposed technique allowed determination of diacerein and rhe...
Source: Bulletin of Faculty of Pharmacy, Cairo University - November 28, 2017 Category: Drugs & Pharmacology Source Type: research

Chronomodulated drug delivery system of Irbesartan: Formulation and development using Desing of Experiment (DoE)
Publication date: Available online 26 November 2017 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Komal Parmar, Almas Shaikh, Hitesh Dalvadi The work is based on pulsatile principles to deliver a programmed dose of Irbesartan, an angiotensin-II receptor antagonist for chronotherapy of hypertension induced by excessive secretion of aldosterone, thereby lower the blood pressure at early morning. Solid dispersion of Irbesartan, a BCS class II drug, was prepared by using Poloxamer-188 by melt method in ratio of 1:1 to increase the dissolution properties of drug. Compressed coated pulsatile tablets in...
Source: Bulletin of Faculty of Pharmacy, Cairo University - November 27, 2017 Category: Drugs & Pharmacology Source Type: research

Anti-hyperglycaemic activity of tuber extract of Chlorophytum alismifolium Baker in streptozotocin-induced hyperglycaemic rats
In conclusion, the results obtained suggest the tuber extract of Chlorophytum alismifolium possesses antihyperglycaemic activity. Graphical abstract (Source: Bulletin of Faculty of Pharmacy, Cairo University)
Source: Bulletin of Faculty of Pharmacy, Cairo University - November 22, 2017 Category: Drugs & Pharmacology Source Type: research

In vitro activity of dihydropyrazole derivatives against Candida species
In this study, we investigate the efficacy of different benzodioxolpyrazoline derivatives against two Candida species. All compounds exhibited potent in vitro antifungal activity against both species. Compound 5 showed the best inhibition zone in comparison to positive controls for Candida albicans. For Candida parapsilosis, all the tested compounds were active while the positive controls were inactive. These compounds provide good starting models for the development of new antimicrobial agents which could be useful especially for the treatment of candidiasis. (Source: Bulletin of Faculty of Pharmacy, Cairo University)
Source: Bulletin of Faculty of Pharmacy, Cairo University - November 21, 2017 Category: Drugs & Pharmacology Source Type: research

Sapium ellipticum (Hochst) Pax leaf extract: Antioxidant potential in CCl4-induced oxidative stress model
Conclusion SE extract appears to have the phyto-proficiency to protect against membrane peroxidation and improve the activities of some first line antioxidant enzymes such a SOD and CAT in vivo. This is probably due to its array of bioactive compounds (α-tocopherol, amentoflavone and lupeol) which we have previously identified and reported. (Source: Bulletin of Faculty of Pharmacy, Cairo University)
Source: Bulletin of Faculty of Pharmacy, Cairo University - November 12, 2017 Category: Drugs & Pharmacology Source Type: research

A comparative study of in vitro antimicrobial, antioxidant and cytotoxic activity of Albizia lebbeck and Acacia nilotica stem bark
Publication date: Available online 2 November 2017 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Mohammad Tuhin Ali, Sheikh Tanzina Haque, Md. Lutful Kabir, Sohel Rana, Md. Enamul Haque Petroleum ether, ethyl acetate and methanol extracts of the stem bark of Albizia lebbeck and Acacia nilotica was investigated for antimicrobial, antioxidant and cytotoxicity assay. The powdered stem bark was extracted successively with petroleum ether, ethyl acetate and methanol solution. The crude extracts were subjected to antimicrobial, antioxidant and cytotoxicity assay by using disc diffusion method, DPPH a...
Source: Bulletin of Faculty of Pharmacy, Cairo University - November 3, 2017 Category: Drugs & Pharmacology Source Type: research

Software based approaches for drug designing and development: A systematic review on commonly used software and its applications
Publication date: Available online 31 October 2017 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Prasad G. Jamkhande, Mahavir H. Ghante, Balaji R. Ajgunde Drug discovery include drug designing and development, is a multifarious and expensive endeavor, where least number of drugs that pass the clinical trials makes it to market. Software based drug discovery and development methods have major role in the development of bioactive compounds for over last three decades. Novel software based methods such as molecular modeling, structure-based drug design, structure-based virtual screening, ligand inte...
Source: Bulletin of Faculty of Pharmacy, Cairo University - November 1, 2017 Category: Drugs & Pharmacology Source Type: research

Enhancement of antibacterial activity of ciprofloxacin hydrochloride by complexation with sodium cholate
This study showed that development of hydrophobic ion pair complex enhances antibacterial activity of ciprofloxacin hydrochloride. (Source: Bulletin of Faculty of Pharmacy, Cairo University)
Source: Bulletin of Faculty of Pharmacy, Cairo University - October 22, 2017 Category: Drugs & Pharmacology Source Type: research

Formulation of risperidone loaded proniosomes for effective transdermal delivery: An in-vitro and in-vivo study
Publication date: Available online 22 September 2017 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Sharda Sambhakar, Sarvesh Paliwal, Swapnil Sharma, Bishambar Singh In the present investigation, proniosomes of risperidone were formulated, optimized and evaluated for effective transdermal delivery in order to overcome the bioavailability issues of orally administered risperidone. The proniosomes were prepared using various sorbitan esters with cholesterol and soya lecithin and were evaluated for in-vitro parameters, ex-vivo permeation and in-vivo performance. Results indicated that the vesicles ...
Source: Bulletin of Faculty of Pharmacy, Cairo University - September 22, 2017 Category: Drugs & Pharmacology Source Type: research

TLC-densitometric and first derivative spectrophotometric methods for determination of cefoxitin-sodium in presence of its alkali-induced degradation product
Publication date: Available online 21 September 2017 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Khalid Abdel-Salam M. Attia, Omar Abdel-Aziz, Nancy Magdy, Ghada F. Mohamed Two simple and accurate methods were developed for quantitative estimation of cefoxitin sodium in presence of its open ring alkali-induced degradation product. The first method was based on TLC separation of the drug from its alkali-induced degradation product followed by densitometric measurement of the intact drug at 254nm. The proposed method obeys Beer’s law in range (1–20µg/band). The second method was first deriv...
Source: Bulletin of Faculty of Pharmacy, Cairo University - September 21, 2017 Category: Drugs & Pharmacology Source Type: research

Improved predictions of nonlinear support vector regression and artificial neural network models via preprocessing of data with orthogonal projection to latent structures: A case study
Publication date: Available online 19 September 2017 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Ibrahim A. Naguib In the presented study, orthogonal projection to latent structures (OPLS) is introduced asa data preprocessing method that handles nonlinear data prior to modelling with two well established nonlinear multivariate models; namely support vector regression (SVR) and artificial neural networks (ANN). The proposed preprocessing proved to significantly improve prediction abilities through removal of uncorrelated data. The study was established based on a case study nonlinear spectrofluori...
Source: Bulletin of Faculty of Pharmacy, Cairo University - September 20, 2017 Category: Drugs & Pharmacology Source Type: research

Effect of myricetin on the transgenic Drosophila model of Parkinson ’s disease
Publication date: Available online 15 September 2017 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Gulshan Ara, Mohammad Afzal, Smita Jyoti, Yasir Hasan Siddique Parkinson’s disease (PD) is a progressive neurodegenerative disorder that affects movement, balance and fine motor control mostly in the elderly population. It is characterized by the progressive loss of neurons in substantia nigra resulting in the depletion of dopamine. Due to ethical reasons the study cannot be performed directly on humans, hence various genetic models of PD based on alpha synuclein, primarily the transgenic over ex...
Source: Bulletin of Faculty of Pharmacy, Cairo University - September 15, 2017 Category: Drugs & Pharmacology Source Type: research