Tapentadol, a novel analgesic: Review of recent trends in synthesis, related substances, analytical methods, pharmacodynamics and pharmacokinetics

Publication date: December 2013 Source:Bulletin of Faculty of Pharmacy, Cairo University, Volume 51, Issue 2 Author(s): Deepti Jain , Pawan Kumar Basniwal This write-up describes the comprehensive facts of tapentadol, on recent trends in synthesis, related substances, analytical methods, pharmacodynamics, pharmacokinetics, adverse effect and drug interaction. Chemically, tapentadol is 3-[(1R,2R)-3-(dimethylamino)-1-ethyl-2-methylpropyl] phenol hydrochloride. Tapentadol is a centrally-acting synthetic novel analgesic which acts as μ-opioid receptor agonist as well as norepinephrine re-uptake inhibitor. Nausea and vomiting are common side effects and tapentadol glucuronide conjugate is a major metabolite excreted in urine. It is synthesized by three different schemes while nine related substances were reported. Tapentadol and its metabolites were determined in plasma matrix by chromatographic methods using spectrofluorometric detection.
Source: Bulletin of Faculty of Pharmacy, Cairo University - Category: Drugs & Pharmacology Source Type: research