Diflucortolone valerate loaded solid lipid nanoparticles as a semisolid topical delivery system

Publication date: Available online 23 December 2015 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Fatma S. Abdel-Salam, Seham A. Elkheshen, Azza A. Mahmoud, Hussein O. Ammar Solid lipid nanoparticles (SLNs) are promising delivery carriers that have been utilized for formulation and delivery of various drugs. For topical administration, they are usually incorporated into gel or cream to increase their residence time, which is time-consuming process and could affect their stability and characteristics. Preparation of solid lipid nanoparticles based semisolid formulations could have potential pharmaceutical applications. The aim of this study was to formulate the corticosteroidal drug, diflucortolone valerate (DFV) into topical semisolid SLN formulations using a rapid cheap one-step process. SLN formulations were developed using a high-shear homogenization combined with sonication, using different types of solid lipids (e.g., Geleol®, Precirol® ATO5, Tristearin® and Compritol® 888ATO) and Poloxamer® 407 as a surfactant. Selection of the lipids and using high lipid concentration were the key elements to get semisolid formulation immediately after sonication without incorporating the nanoparticles into a gel or a cream base. DFV SLN formulations possessed average particle size ranging from 203.71±5.61 to 1421.00±16.32nm with a narrow size distribution and possessed shear thinning behavior. Incorporation of lipid based surfactants (LabrasolÂ...
Source: Bulletin of Faculty of Pharmacy, Cairo University - Category: Drugs & Pharmacology Source Type: research