Anticonvulsant activity of novel 1-(morpholinomethyl)-3-substituted isatin derivatives

Publication date: June 2014 Source:Bulletin of Faculty of Pharmacy, Cairo University, Volume 52, Issue 1 Author(s): Govindaraj Saravanan , Veerachamy Alagarsamy , Pandurangan Dineshkumar A variety of novel isatin derivatives 5a–5j and 6a–6j were synthesized and characterized by spectroscopic means and elemental analysis. The title compounds were investigated for antiepileptic activity using MES and scPTZ seizures tests. Neurotoxicity study was performed by the rotorod test. The relationship between the functional group variation and the biological activity of the evaluated compounds was discussed. Among the synthesized analogs, the most active one was 6f that revealed protection in MES at a dose of 30mg/kg (i.p.) after 0.5h and 4h. This molecule also provided protection in the scPTZ at a dose of 100mg/kg (0.5h) and 300mg/kg (4h). Graphical abstract Highlights
Source: Bulletin of Faculty of Pharmacy, Cairo University - Category: Drugs & Pharmacology Source Type: research