The combined induction of liver progenitor cells and the suppression of stellate cells by small molecules reverts chronic hepatic dysfunction
Conclusions: Hepatocyte-derived liver progenitor-like cells are crucial for liver regeneration during chronic hepatic injuries. The administration of HACY, which allowed the induction of endogenous CD24+ progenitor cells and the inactivation of HSCs, exerts beneficial effects in the treatment of liver fibrosis by re-establishing a balance favoring liver regeneration while preventing fibrotic responses. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Wei-Jian Huang, Xu Zhou, Gong-Bo Fu, Min Ding, Hong-Ping Wu, Min Zeng, Hong-Dan Zhang, Ling-Yan Xu, Yi Gao, Hong-Yang Wang, He-Xin Yan Tags: Research Paper Source Type: research
Computational methods for cancer driver discovery: A survey
Identifying the genes responsible for driving cancer is of critical importance for directing treatment. Accordingly, multiple computational tools have been developed to facilitate this task. Due to the different methods employed by these tools, different data considered by the tools, and the rapidly evolving nature of the field, the selection of an appropriate tool for cancer driver discovery is not straightforward. This survey seeks to provide a comprehensive review of the different computational methods for discovering cancer drivers. We categorise the methods into three groups; methods for single driver identification, ...
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Vu Viet Hoang Pham, Lin Liu, Cameron Bracken, Gregory Goodall, Jiuyong Li, Thuc Duy Le Tags: Research Paper Source Type: research
Direct optogenetic stimulation of smooth muscle cells to control gastric contractility
Conclusions: We demonstrate direct optogenetic stimulation of SMC to control gastric contractility. This completely new approach could allow for the restoration of motility in gastroparesis in the future. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Markus Vogt, Benjamin Schulz, Ahmed Wagdi, Jan Lebert, Gijsbert J. van Belle, Jan Christoph, Tobias Bruegmann, Robert Patejdl Tags: Research Paper Source Type: research
Targeting long noncoding RNA PMIF facilitates osteoprogenitor cells migrating to bone formation surface to promote bone formation during aging
Conclusion: Toward translational medicine, this study hints that targeting lnc-PMIF to facilitate aged OPCs migrating to bone formation surface could be a brand-new anabolic strategy for aging-related osteoporosis. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Dijie Li, Jin Liu, Chaofei Yang, Ye Tian, Chong Yin, Lifang Hu, Zhihao Chen, Fan Zhao, Ru Zhang, Aiping Lu, Ge Zhang, Airong Qian Tags: Research Paper Source Type: research
HDAC1 and 2 regulate endothelial VCAM-1 expression and atherogenesis by suppressing methylation of the GATA6 promoter
Conclusions: HDAC1/2 contributes to VCAM-1 expression and atherosclerosis by suppressing STAT3 acetylation-dependent GATA6 promoter methylation. These findings may provide a rationale for HDAC1/2-targeting therapy in atherosclerotic heart disease. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Chengxiu Hu, Kai Peng, Qianqian Wu, Yiying Wang, Xing Fan, Dai-Min Zhang, Anthony G. Passerini, ChongXiu Sun Tags: Research Paper Source Type: research
Biomechanical sensing of in vivo magnetic nanoparticle hyperthermia-treated melanoma using magnetomotive optical coherence elastography
Conclusions: This study exploits the theranostic functionality of MNPs and investigates the MH-induced stiffness change on in vivo melanoma-bearing mice with MM-OCT and MM-OCE for the first time. It was discovered that the elasticity alteration of the melanoma tumor after MH treatment depends on both thermal dosage and the morphological features of the tumor. In summary, changes in tissue-level elasticity can potentially be a physically and physiologically meaningful metric and integrative therapeutic marker for MH treatment, while MM-OCE can be a suitable dosimetry technique. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Pin-Chieh Huang, Eric J. Chaney, Edita Aksamitiene, Ronit Barkalifa, Darold R. Spillman, Bethany J. Bogan, Stephen A. Boppart Tags: Research Paper Source Type: research
An exosomal-carried short periostin isoform induces cardiomyocyte proliferation
Conclusions: Our results show, for the first time, that CPC-secreted exosomes promote cardiomyocyte cell cycle-reentry via a short periostin isoform expressed on their surfaces, whereas recombinant full-length periostin does not. These findings highlight isoform-specific roles of periostin in cardiomyocyte proliferation. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Carolina Balbi, Giuseppina Milano, Tudor E. Fertig, Edoardo Lazzarini, Sara Bolis, Yoshiaki Taniyama, Fumihiro Sanada, Dario Di Silvestre, Pierluigi Mauri, Mihaela Gherghiceanu, Thomas F. L ü scher, Lucio Barile, Giuseppe Vassalli Tags: Research Paper Source Type: research
Endogenous glutamate determines ferroptosis sensitivity via ADCY10-dependent YAP suppression in lung adenocarcinoma
Conclusions: Endogenous glutamate is critical for ferroptosis sensitivity following the inhibition of system XC- in LUAD cells, and ferroptosis-based treatment is a good choice for LUAD patients with later-stage and/or therapy-resistant tumors. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Xiao Zhang, Keke Yu, Lifang Ma, Zijun Qian, Xiaoting Tian, Yayou Miao, Yongjie Niu, Xin Xu, Susu Guo, Yueyue Yang, Zhixian Wang, Xiangfei Xue, Chuanjia Gu, Wentao Fang, Jiayuan Sun, Yongchun Yu, Jiayi Wang Tags: Research Paper Source Type: research
Application of mesenchymal stem cell therapy for aging frailty: from mechanisms to therapeutics
Aging frailty is a complex geriatric syndrome that becomes more prevalent with advancing age. It constitutes a major health problem due to frequent adverse outcomes. Frailty is characterized by disruption of physiological homeostasis and progressive decline of health status. Multiple factors contribute to development of frailty with advancing age, including genome instability, DNA damage, epigenetic alternations, stem cell exhaustion, among others. These interrelated factors comprehensively result in loss of tissue homeostasis and diminished reserve capacity in frailty. Therefore, the aged organism gradually represents sym...
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Yingqian Zhu, Jianli Ge, Ce Huang, Hailiang Liu, Hua Jiang Tags: Review Source Type: research
Nodal-induced L1CAM/CXCR4 subpopulation sustains tumor growth and metastasis in colorectal cancer derived organoids
Conclusion: In conclusion, we demonstrated that a subpopulation of migrating L1CAMhigh/CXCR4high is essential for tumor progression. Together, these findings suggest that strategies aimed at modulating the Nodal signaling could have important clinical applications to inhibit colorectal cancer-derived metastasis. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Donatella Delle Cave, Xavier Hernando-Momblona, Marta Sevillano, Gabriella Minchiotti, Enza Lonardo Tags: Research Paper Source Type: research
Externally triggered smart drug delivery system encapsulating idarubicin shows superior kinetics and enhances tumoral drug uptake and response
Conclusions: We show that a shift in selection of chemotherapeutics is urgently needed, away from the classic drugs towards selection based on properties of a chemotherapeutic in context of the nanoparticle and delivery mode, to maximize the therapeutic efficacy. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Tao Lu, Dieter Haemmerich, Hui Liu, Ann L.B. Seynhaeve, Gerard C. van Rhoon, Adriaan B. Houtsmuller, Timo L.M. ten Hagen Tags: Research Paper Source Type: research
Quantitative self-assembly of pure drug cocktails as injectable nanomedicines for synergistic drug delivery and cancer therapy
Conclusions: Overall, this approach does not require any carrier matrices, offering a scalable and cost-effective methodology to create a new generation of nanomedicines for the safe and efficient delivery of drug combinations. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Xiaona Chen, Binbin Xie, Lingling Huang, Jianqin Wan, Yuchen Wang, Xiaowei Shi, Yiting Qiao, Haihan Song, Hangxiang Wang Tags: Research Paper Source Type: research
Cytomegalovirus infection is associated with an increase in aortic stiffness in older men which may be mediated in part by CD4 memory T-cells
Conclusion: CMV infection increases the CVD risk of older men by increasing cfPWV. This may be mediated in part by increased proportions of CD4 Tmem, higher numbers of which are found in CMV+ older people and more so among men than women. Given the high prevalence of CMV worldwide, our findings point to a significant global health issue. Novel strategies to mitigate the increased CVD risk associated with CMV may be required. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Frances Kirkham, Alejandra Pera, Amanda M. Simanek, Aalia Bano, George Morrow, Bernhard Reus, Stefano Caserta, Helen E. Smith, Kevin A Davies, Chakravarthi Rajkumar, Florian Kern Tags: Research Paper Source Type: research
Radiation-induced abscopal reproductive effect is driven by TNF- α /p38 MAPK/Rac1 axis in Sertoli cells
Conclusions: Our findings imply for the first time that YWHAZ-mediated Rac1 nuclear translocation plays central roles in RIARE, and TNF-α/p38 MAPK/Rac1 axis can be employed as a therapeutic target against RIARE for young male patients receiving hypofractionated radiotherapy. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Songling Hu, Lin Zhu, Yimeng Song, Xinrui Zhao, Qianping Chen, Yan Pan, Jianghong Zhang, Yang Bai, Haowen Zhang, Chunlin Shao Tags: Research Paper Source Type: research
Homeobox B5 promotes metastasis and poor prognosis in Hepatocellular Carcinoma, via FGFR4 and CXCL1 upregulation
Conclusion: HOXB5 was a potential prognostic biomarker in HCC patients and targeting this loop may provide a promising treatment strategy for the inhibition of HOXB5-mediated HCC metastasis. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Qin He, Wenjie Huang, Danfei Liu, Tongyue Zhang, Yijun Wang, Xiaoyu Ji, Meng Xie, Mengyu Sun, Dean Tian, Mei Liu, Limin Xia Tags: Research Paper Source Type: research
