The Current Landscape of Antibody-based Therapies in Solid Malignancies
Over the past three decades, monoclonal antibodies (mAbs) have revolutionized the landscape of cancer therapy. Still, this benefit remains restricted to a small proportion of patients due to moderate response rates and resistance emergence. The field has started to embrace better mAb-based formats with advancements in molecular and protein engineering technologies. The development of a therapeutic mAb with long-lasting clinical impact demands a prodigious understanding of target antigen, effective mechanism of action, gene engineering technologies, complex interplay between tumor and host immune system, and biomarkers for ...
Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Ashu Shah, Sanchita Rauth, Abhijit Aithal, Sukhwinder Kaur, Koelina Ganguly, Catherine Orzechowski, Grish C Varshney, Maneesh Jain, Surinder K Batra Tags: Review Source Type: research
Recent advances in supramolecular antidotes
Poisons always have fascinated humankind. Initially considered as deleterious or hazardous substances, the modern era has witnessed the controlled utilization of dangerous poisons in medicine and cosmetics. Simultaneously, antidotes have become crucial as reversal agents to counteract the effects of a poison, and they are also used today to positively cancel the benefits of a poison after use. Currently, the majority of poisons are composed of small molecules. This review focuses on recent developments to reverse or prevent toxic effects of poisons by encapsulation in host molecules. Cyclodextrins, cucurbiturils, acyclic c...
Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Hang Yin, Xiangjun Zhang, Jianwen Wei, Siyu Lu, David Bardelang, Ruibing Wang Tags: Review Source Type: research
Photosensitizer-based multimodal PSMA-targeting ligands for intraoperative detection of prostate cancer
Conclusion: We developed a novel PSMA-targeting ligand, optimized for multimodal image-guided PCa surgery combined with targeted photodynamic therapy. (Source: Theranostics)
Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Yvonne H.W. Derks, Mark Rijpkema, Helene I.V. Amatdjais-Groenen, Annemarie Kip, Gerben M. Franssen, J. P. Michiel Sedelaar, Diederik M. Somford, Michiel Simons, Peter Laverman, Martin Gotthardt, Dennis W. P. M. L ö wik, Susanne L ü tje, Sandra Heskamp Tags: Research Paper Source Type: research
Ascorbic acid induced HepG2 cells' apoptosis via intracellular reductive stress: Erratum
(Source: Theranostics)
Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Xiaonan Gao, Keyan Wei, Bo Hu, Kehua Xu, Bo Tang Tags: Erratum Source Type: research
Blood TfR+ exosomes separated by a pH-responsive method deliver chemotherapeutics for tumor therapy: Erratum
(Source: Theranostics)
Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Lijun Yang, Donglin Han, Qi Zhan, Xueping Li, Peipei Shan, Yunjie Hu, Han Ding, Yu Wang, Lei Zhang, Yuan Zhang, Sheng Xue, Jin Zhao, Xin Hou, Yin Wang, Peifeng Li, Xubo Yuan, Hongzhao Qi Tags: Erratum Source Type: research
