Multi-omics study reveals that statin therapy is associated with restoration of gut microbiota homeostasis and improvement in outcomes in patients with acute coronary syndrome
Conclusions: Our study suggests that statin treatment might benefit ACS patients by modulating the composition and function of the gut microbiome, which might result in improved circulating metabolites and reduced metabolic risk. Our findings provide new insights for understanding the heterogenic roles of statins in ACS patients through host gut microbiota metabolic interactions. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Xiaomin Hu, Hanyu Li, Xinyue Zhao, Ruilin Zhou, Honghong Liu, Yueshen Sun, Yue Fan, Yanan Shi, Shanshan Qiao, Shuangjiang Liu, Hongwei Liu, Shuyang Zhang Tags: Research Paper Source Type: research
MYBL2 disrupts the Hippo-YAP pathway and confers castration resistance and metastatic potential in prostate cancer
Conclusions: Our results reveal a novel molecular mechanism conferring resistance to ADT and provide a strong rationale for potential therapeutic strategies against CRPC. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Qiji Li, Min Wang, Yanqing Hu, Ensi Zhao, Jun Li, Liangliang Ren, Meng Wang, Yuandong Xu, Qian Liang, Di Zhang, Yingrong Lai, Shaoyu Liu, Xinsheng Peng, Chengming Zhu, Liping Ye Tags: Research Paper Source Type: research
Extracellular vesicles derived from M1 macrophages deliver miR-146a-5p and miR-146b-5p to suppress trophoblast migration and invasion by targeting TRAF6 in recurrent spontaneous abortion
Conclusions: Our findings indicate that miR-146a-5p and miR-146b-5p derived from EVs play important roles in intercellular communication between M1 macrophages and trophoblasts, illuminating a novel mechanism in M1 macrophage regulation of trophoblasts and their role in RSA. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Jinli Ding, Yan Zhang, Xiaopeng Cai, Yi Zhang, Sisi Yan, Jiayu Wang, Sainan Zhang, Tailang Yin, Chaogang Yang, Jing Yang Tags: Research Paper Source Type: research
Saikosaponin D exhibits anti-leukemic activity by targeting FTO/m6A signaling
Conclusion: Our findings demonstrated that FTO-dependent m6A RNA methylation mediated the anti-leukemic actions of SsD, thereby opening a window to develop SsD as an epitranscriptome-base drug for leukemia therapy. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Kaiju Sun, Yangyang Du, Yuzhu Hou, Mingyue Zhao, Jiajia Li, Yazhe Du, Lingxiao Zhang, Changbao Chen, Hongmei Yang, Fei Yan, Rui Su Tags: Research Paper Source Type: research
The PSMD14 inhibitor Thiolutin as a novel therapeutic approach for esophageal squamous cell carcinoma through facilitating SNAIL degradation
Conclusion: Our findings demonstrate for the first time that suppression of PSMD14/SNAIL axis by THL could be a novel and promising therapeutic approach for ESCC clinical therapy. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Chao Jing, Xingchen Li, Mengqian Zhou, Shengchi Zhang, Qingchuan Lai, Dandan Liu, Beibei Ye, Linqi Li, Yue Wu, Hong Li, Kai Yue, Peng Chen, Xiaofeng Yao, Yansheng Wu, Yuansheng Duan, Xudong Wang Tags: Research Paper Source Type: research
Engineering protein theranostics using bio-orthogonal asparaginyl peptide ligases
Conclusion: Bio-orthogonal tandem ligation using two asparaginyl peptide ligases with differential substrate specificities is a straightforward approach for the preparation of multifunctional protein biologics as potential theranostics. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Zhen Wang, Dingpeng Zhang, Xinya Hemu, Side Hu, Janet To, Xiaohong Zhang, Julien Lescar, James P. Tam, Chuan-Fa Liu Tags: Research Paper Source Type: research
Computed tomography imaging of macrophage phagocytic activity in abdominal aortic aneurysm
Conclusions: By establishing the feasibility of CT-based molecular imaging of phagocytic activity in AAA, this study links the inflammatory signal on early time point images to AAA evolution. This readily available technology overcomes an important barrier to cross-sectional, longitudinal and outcome studies, not only in AAA, but also in other cardiovascular pathologies and facilitates the evaluation of modulatory interventions, and ultimately upon clinical translation, patient management. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Jakub Toczek, Parnaz Boodagh, Nowshin Sanzida, Mean Ghim, Mani Salarian, Kiran Gona, Gunjan Kukreja, Saranya Rajendran, Linyan Wei, Jinah Han, Jiasheng Zhang, Jae-Joon Jung, Morven Graham, Xinran Liu, Mehran M. Sadeghi Tags: Research Paper Source Type: research
High fat diet, gut microbiome and gastrointestinal cancer
Gastrointestinal cancer is currently one of the main causes of cancer death, with a large number of cases and a wide range of lesioned sites. A high fat diet, as a public health problem, has been shown to be correlated with various digestive system diseases and tumors, and can accelerate the occurrence of cancer due to inflammation and altered metabolism. The gut microbiome has been the focus of research in recent years, and associated with cell damage or tumor immune microenvironment changes via direct or extra-intestinal effects; this may facilitate the occurrence and development of gastrointestinal tumors. Based on rese...
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Yao Tong, Huiru Gao, Qiuchen Qi, Xiaoyan Liu, Juan Li, Jie Gao, Peilong Li, Yunshan Wang, Lutao Du, Chuanxin Wang Tags: Review Source Type: research
Synergistic enhancement of tendon-to-bone healing via anti-inflammatory and pro-differentiation effects caused by sustained release of Mg2+/curcumin from injectable self-healing hydrogels
Conclusions: The composite hydrogel mediated sustained in situ release of curcumin and Mg2+ to effectively promote rotator cuff tendon-to-bone healing via anti-inflammatory and pro-differentiation effects. Therefore, this composite hydrogel offers significant promise for rotator cuff repair. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Baojun Chen, Yongping Liang, Jing Zhang, Lang Bai, Meiguang Xu, Qian Han, Xuezhe Han, Jintao Xiu, Meng Li, Xiaoling Zhou, Baolin Guo, Zhanhai Yin Tags: Research Paper Source Type: research
ZEB1 enhances Warburg effect to facilitate tumorigenesis and metastasis of HCC by transcriptionally activating PFKM
Conclusions: Our study reveals a novel mechanism of ZEB1 in promoting HCC by activating the transcription of PFKM, establishing the direct link of ZEB1 to the promotion of glycolysis and Warburg effect and suggesting that inhibition of ZEB1 transcriptional activity toward PFKM may be a potential therapeutic strategy for HCC. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Yanming Zhou, Furong Lin, Tao Wan, Ai Chen, Huihui Wang, Bin Jiang, Wentao Zhao, Shan Liao, Shijie Wang, Guannan Li, Zhenzhen Xu, Jinyang Wang, Jia Zhang, Huanhuan Ma, Donghai Lin, Qinxi Li Tags: Research Paper Source Type: research
Crosstalk between coagulation and complement activation promotes cardiac dysfunction in arrhythmogenic right ventricular cardiomyopathy
Conclusions: These results suggest that crosstalk between the coagulation and complement systems plays a pathogenic role in cardiac dysfunction in ARVC. Thus, understanding this crosstalk may have important clinical implications with respect to diagnosing and treating ARVC. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Jie Ren, Konstantinos Tsilafakis, Liang Chen, Konstantinos Lekkos, Ioanna Kostavasili, Aimilia Varela, Dennis V. Cokkinos, Constantinos H. Davos, Xiaogang Sun, Jiangping Song, Manolis Mavroidis Tags: Research Paper Source Type: research
Enhanced anti-PD-1 therapy in hepatocellular carcinoma by tumor vascular disruption and normalization dependent on combretastatin A4 nanoparticles and DC101
Conclusion: These results reveal a novel approach to enhance anti-PD-1 therapy with VDAs + VEGF/VEGFR2 inhibitors in HCC. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Xin Bao, Na Shen, Yan Lou, Haiyang Yu, Yue Wang, Linlin Liu, Zhaohui Tang, Xuesi Chen Tags: Research Paper Source Type: research
A pain killer without analgesic tolerance designed by co-targeting PSD-95-nNOS interaction and α 2-containning GABAARs
Conclusion: By targeting nNOS-PSD-95 interaction and α2-containing GABAAR simultaneously, chronic use of ZL006-05 can avoid analgesic tolerance and unwanted side effects. Therefore, we offer a novel candidate drug without analgesic tolerance for treating neuropathic pain. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Jun Li, Lin Zhang, Chu Xu, Ying-Ying Shen, Yu-Hui Lin, Yu Zhang, Hai-Yin Wu, Lei Chang, Ying-Dong Zhang, Rong Chen, Zheng-Ping Zhang, Chun-Xia Luo, Fei Li, Dong-Ya Zhu Tags: Research Paper Source Type: research
Antioxidant activity of mesenchymal stem cell-derived extracellular vesicles restores hippocampal neurons following seizure damage
Conclusions: We have shown that MSC-EVs facilitate the reconstruction of hippocampal neurons associated with the Nrf2 defense system in response to oxidative insults. Our study highlights the clinical value of EV-therapy in neurological disorders such as seizures. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Qiang Luo, Panpan Xian, Tian Wang, Shengxi Wu, Tangna Sun, Wenting Wang, Bo Wang, Hao Yang, Yanping Yang, Han Wang, Weiping Liu, Qianfa Long Tags: Research Paper Source Type: research
The kynurenine derivative 3-HAA sensitizes hepatocellular carcinoma to sorafenib by upregulating phosphatases
Conclusion: This study demonstrates that 3-HAA sensitizes HCC cells to sorafenib by upregulation of phosphatases, suggesting it as a promising molecule for HCC therapy. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Guifang Gan, Zhaopeng Shi, Chengfang Shangguan, Jieying Zhang, Yuan Yuan, Lei Chen, Weiren Liu, Biao Li, Songshu Meng, Wujun Xiong, Jun Mi Tags: Research Paper Source Type: research
