Saikosaponin D exhibits anti-leukemic activity by targeting FTO/m6A signaling

Conclusion: Our findings demonstrated that FTO-dependent m6A RNA methylation mediated the anti-leukemic actions of SsD, thereby opening a window to develop SsD as an epitranscriptome-base drug for leukemia therapy.

Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Kaiju Sun, Yangyang Du, Yuzhu Hou, Mingyue Zhao, Jiajia Li, Yazhe Du, Lingxiao Zhang, Changbao Chen, Hongmei Yang, Fei Yan, Rui Su Tags: Research Paper Source Type: research