Combination of long-acting TRAIL and tumor cell-targeted photodynamic therapy as a novel strategy to overcome chemotherapeutic multidrug resistance and TRAIL resistance of colorectal cancer
Conclusions: Tumor cell-targeted PDT extensively sensitizes CRC cells to TRAIL. Combination therapy of long-acting TRAIL and PDT is promising to combat CRC with both chemotherapeutic MDR and TRAIL resistance, which might be developed as a novel strategy for precision therapy of refractory CRC. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Tianshan She, Qiuxiao Shi, Zhao Li, Yanru Feng, Hao Yang, Ze Tao, Heng Li, Jie Chen, Shisheng Wang, Yan Liang, Jingqiu Cheng, Xiaofeng Lu Tags: Research Paper Source Type: research
N6-methyladenosine-induced circ1662 promotes metastasis of colorectal cancer by accelerating YAP1 nuclear localization
Conclusions: METTL3-induced circ1662 promoted CRC cell invasion and migration by accelerating YAP1 nuclear transport. This result implies that circ1662 is a new prognostic and therapeutic marker for CRC metastasis. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Chen Chen, Weitang Yuan, Quanbo Zhou, Bo Shao, Yuying Guo, Weiwei Wang, Shuaixi Yang, Yaxin Guo, Luyang Zhao, Qin Dang, Xiuxiu Yang, Guixian Wang, Qiaozhen Kang, Zhenyu Ji, Jinbo Liu, Zhenqiang Sun Tags: Research Paper Source Type: research
Trio cooperates with Myh9 to regulate neural crest-derived craniofacial development
Conclusions: Here, we identified that Trio, interacting mostly with Myh9, acts as a key regulator of NCC migration and differentiation during craniofacial development. Our results indicate that trio morphant zebrafish and Wnt1-cre;Triofl/fl mice offer potential model systems to facilitate the study of the pathogenic mechanisms of Trio mutations causing craniofacial abnormalities. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Shuyu Guo, Li Meng, Haojie Liu, Lichan Yuan, Na Zhao, Jieli Ni, Yang Zhang, Jingjing Ben, Yi-Ping Li, Junqing Ma Tags: Research Paper Source Type: research
Compensatory combination of mTOR and TrxR inhibitors to cause oxidative stress and regression of tumors
Conclusion: Our findings identify a promising therapeutic combination for cancer and has important implications for developing mTOR inhibitor-based combination treatments. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Yiqun Xia, Jundixia Chen, Yun Yu, Fengjiao Wu, Xin Shen, Chenyu Qiu, Tingting Zhang, Lin Hong, Peisen Zheng, Rongrong Shao, Chenxin Xu, Fang Wu, Wei Chen, Congying Xie, Ri Cui, Peng Zou Tags: Research Paper Source Type: research
Ultrasound-mediated augmented exosome release from astrocytes alleviates amyloid- β -induced neurotoxicity
Conclusion: Our results imply that US-HA-Exo have the potential to provide neuroprotective effects to reverse oligomeric amyloid-β-induced cytotoxicity in vitro and, when combined with FUS-induced BBB opening, enable the clearance of amyloid-β plaques in vivo. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Zhiting Deng, Jieqiong Wang, Yang Xiao, Fei Li, Lili Niu, Xin Liu, Long Meng, Hairong Zheng Tags: Research Paper Source Type: research
Hepatic miR-378 modulates serum cholesterol levels by regulating hepatic bile acid synthesis
Conclusions: TH-responsive hepatic miR-378 is capable of modulating serum cholesterol levels by regulating both the classic and alternative BA synthetic pathways. Our study not only identifies a previously undescribed role of hepatic miR-378 but also provides new cholesterol-lowering approaches. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Chao Sun, Wei Liu, Zhiqiang Lu, Yan Li, Shengnan Liu, Zhili Tang, Ying Yan, Zhiyang Li, Hua Feng, Duo Zhang, Yun Liu, Zhong-Ze Fang, Changtao Jiang, Qiurong Ding, Jingjing Jiang, Hao Ying Tags: Research Paper Source Type: research
NAD+-boosting therapy alleviates nonalcoholic fatty liver disease via stimulating a novel exerkine Fndc5/irisin
Conclusions: The findings from this research for the first time demonstrate that NAD+-boosting therapy reverses NAFLD by regulating SIRT2-deppendent Fndc5 deacetylation and deubiquitination, which results in a stimulation of Fndc5/irisin, a novel exerkine. These results suggest that Fndc5/irisin may be a potential nexus between physical exercise and NAD+-boosting therapy in metabolic pathophysiology. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Dong-Jie Li, Si-Jia Sun, Jiang-Tao Fu, Shen-Xi Ouyang, Qin-Jie Zhao, Li Su, Qing-Xi Ji, Di-Ynag Sun, Jia-Hui Zhu, Guo-Yan Zhang, Jia-Wei Ma, Xiu-Ting Lan, Yi Zhao, Jie Tong, Guo-Qiang Li, Fu-Ming Shen, Pei Wang Tags: Research Paper Source Type: research
Intratumor heterogeneity of breast cancer detected by epialleles shows association with hypoxic microenvironment
Conclusions: The analysis of intratumor DNA methylation heterogeneity based on epialleles reveals that disordered methylation patterns in tumor core are associated with hypoxic microenvironment, which provides a framework for understanding biological heterogeneous behavior and guidance for developing effective treatment schemes for breast cancer patients. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Yihan Wang, Yan Zhang, Yan Huang, Chuangeng Chen, Xingda Zhang, Ying Xing, Yue Gu, Mengyan Zhang, Li Cai, Shouping Xu, Baoqing Sun Tags: Research Paper Source Type: research
The CK1 δ / ε -AES axis regulates tumorigenesis and metastasis in colorectal cancer
Conclusions: Our results revealed that the CK1δ/ε-AES axis is important for CRC tumorigenesis and metastasis, and targeted inhibition of this axis may be a potential therapeutic strategy for CRC. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Zhongyuan Wang, Liang Zhou, Yejun Wang, Quanzhou Peng, Huan Li, Xin Zhang, Zijie Su, Jiaxing Song, Qi Sun, Sapna Sayed, Shanshan Liu, Desheng Lu Tags: Research Paper Source Type: research
Exosome-inflammasome crosstalk and their roles in inflammatory responses
Inflammasome is a complex of multiple proteins found in cytoplasm of the cells activated by infectious and/or non-infectious stimuli. This complex involves caspase-1 activation, leading to unconventional secretion of interleukin-1β (IL-1β) and IL-18 and inflammatory cascade. Exosome is the nanoscale membrane-bound extracellular vesicle that plays significant roles in intercellular communications by carrying bioactive molecules, e.g., proteins, RNAs, microRNAs (miRNAs), DNAs, from one cell to the others. In this review, we provide the update information on the crosstalk between exosome and inflammasome and their r...
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Chadanat Noonin, Visith Thongboonkerd Tags: Review Source Type: research
Charge-switchable zwitterionic polycarboxybetaine particle as an intestinal permeation enhancer for efficient oral insulin delivery
Conclusion: These findings indicate that this system can provide a platform for oral insulin and other protein drugs delivery. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Yan Li, Weihong Ji, Huan Peng, Ruichen Zhao, Tianlu Zhang, Zhiguo Lu, Jun Yang, Ruiyuan Liu, Xin Zhang Tags: Research Paper Source Type: research
Pancreatic ductal deletion of S100A9 alleviates acute pancreatitis by targeting VNN1-mediated ROS release to inhibit NLRP3 activation
Conclusions: Our study showed the important regulatory effect of S100A9 on pancreatic duct injury during AP and revealed that inhibition of the S100A9-VNN1 interaction may be a key therapeutic target for this disease. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Hong Xiang, Fangyue Guo, Xufeng Tao, Qi Zhou, Shilin Xia, Dawei Deng, Lunxu Li, Dong Shang Tags: Research Paper Source Type: research
The subcellular redistribution of NLRC5 promotes angiogenesis via interacting with STAT3 in endothelial cells
Conclusions: In the ischemic microenvironment, NLRC5 protein accumulates in the nucleus of ECs and enhances STAT3 transcriptional activity for angiogenesis. These findings establish NLRC5 as a novel modulator of VEGFA signaling, providing a new target for angiogenic therapy to foster tissue regeneration. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Xu Xu, Yefei Shi, Peipei Luan, Wenxin Kou, Bo Li, Ming Zhai, Shuangjie You, Qing Yu, Jianhui Zhuang, Weixia Jian, Mark W. Feinberg, Wenhui Peng Tags: Research Paper Source Type: research
Impact of sodium glucose cotransporter 2 (SGLT2) inhibitors on atherosclerosis: from pharmacology to pre-clinical and clinical therapeutics
Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are new oral drugs for the therapy of patients with type 2 diabetes mellitus (T2DM). Research in the past decade has shown that drugs of the SGLT2i class, such as empagliflozin, canagliflozin, and dapagliflozin, have pleiotropic effects in preventing cardiovascular diseases beyond their favorable impact on hyperglycemia. Of clinical relevance, recent landmark cardiovascular outcome trials have demonstrated that SGLT2i reduce major adverse cardiovascular events, hospitalization for heart failure, and cardiovascular death in T2DM patients with/without cardiovascular diseases...
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Zhenghong Liu, Xiaoxuan Ma, Iqra Ilyas, Xueying Zheng, Sihui Luo, Peter J. Little, Danielle Kamato, Amirhossein Sahebkar, Weiming Wu, Jianping Weng, Suowen Xu Tags: Review Source Type: research
LncRNA PRADX-mediated recruitment of PRC2/DDX5 complex suppresses UBXN1 expression and activates NF- κ B activity, promoting tumorigenesis
Conclusions: PRADX acts as a cancer driver and may serve as a potential therapeutic target for glioblastoma and colon adenocarcinoma. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Yansheng Li, Xing Liu, Xiaoteng Cui, Yanli Tan, Qixue Wang, Yunfei Wang, Can Xu, Chuan Fang, Chunsheng Kang Tags: Research Paper Source Type: research
