Trio cooperates with Myh9 to regulate neural crest-derived craniofacial development

Conclusions: Here, we identified that Trio, interacting mostly with Myh9, acts as a key regulator of NCC migration and differentiation during craniofacial development. Our results indicate that trio morphant zebrafish and Wnt1-cre;Triofl/fl mice offer potential model systems to facilitate the study of the pathogenic mechanisms of Trio mutations causing craniofacial abnormalities.

Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Shuyu Guo, Li Meng, Haojie Liu, Lichan Yuan, Na Zhao, Jieli Ni, Yang Zhang, Jingjing Ben, Yi-Ping Li, Junqing Ma Tags: Research Paper Source Type: research