IL-37 exerts therapeutic effects in experimental autoimmune encephalomyelitis through the receptor complex IL-1R5/IL-1R8
Conclusions: This study presents novel data indicating that IL-37 exerts therapeutic effects in EAE by acting through the extracellular receptor complex IL-1R5/IL-1R8, and that this protective physiological mechanism is defective in MS individuals. IL-37 may therefore represent a novel therapeutic avenue for the treatment of MS with great promising potential. (Source: Theranostics)
Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Alba S á nchez-Fern á ndez, Stephanie Zandee, Jes ú s Amo-Aparicio, Marc Charabati, Alexandre Prat, Cecilia Garlanda, Elan Z. Eisenmesser, Charles A. Dinarello, Rub è n L ó pez-Vales Tags: Research Paper Source Type: research
A role for intestinal alkaline phosphatase in preventing liver fibrosis
Conclusions: Endogenous IAP is decreased during liver fibrosis, perhaps contributing to the gut barrier dysfunction and worsening fibrosis. Oral IAP protects the gut barrier and further prevents the development of liver fibrosis via a TLR4-mediated mechanism. (Source: Theranostics)
Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Yang Liu, Paul M. Cavallaro, Byeong-Moo Kim, Tao Liu, Hongyan Wang, Florian K ü hn, Fatemeh Adiliaghdam, Enyu Liu, Robin Vasan, Ehsan Samarbafzadeh, Matthew Z. Farber, Junhui Li, Meng Xu, Vidisha Mohad, Michael Choi, Richard A. Hodin Tags: Research Paper Source Type: research
Small molecule-based treatment approaches for intervertebral disc degeneration: Current options and future directions
Low back pain (LBP) is a major reason for disability, and symptomatic intervertebral disc (IVD) degeneration (IDD) contributes to roughly 40% of all LBP cases. Current treatment modalities for IDD include conservative and surgical strategies. Unfortunately, there is a significant number of patients in which conventional therapies fail with the result that these patients remain suffering from chronic pain and disability. Furthermore, none of the current therapies successfully address the underlying biological problem - the symptomatic degenerated disc. Both spinal fusion as well as total disc replacement devices reduce spin...
Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Amir Kamali, Reihane Ziadlou, Gernot Lang, Judith Pfannkuche, Shangbin Cui, Zhen Li, R. Geoff Richards, Mauro Alini, Sibylle Grad Tags: Review Source Type: research
A skeleton muscle model using GelMA-based cell-aligned bioink processed with an electric-field assisted 3D/4D bioprinting
Conclusion: The C2C12-laden GelMA structure demonstrated effective myotube formation/maturation in response to stimulation with an electric field. Based on these results, we propose that our cell-laden fibrous bundles can be employed as in vitro drug testing models for obtaining insights into the various myogenic responses. (Source: Theranostics)
Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Gi Hoon Yang, Wonjin Kim, Juyeon Kim, GeunHyung Kim Tags: Research Paper Source Type: research
Extracellular-vesicles delivered tumor-specific sequential nanocatalysts can be used for MRI-informed nanocatalytic Therapy of hepatocellular carcinoma
Conclusion: This application of surface-engineering EVs not only proves the high-performance catalytic therapeutic modality of GE@EVs for HCC, but also broadens the versatile bio-applications of EVs. (Source: Theranostics)
Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Han Wu, Hao Xing, Meng-Chao Wu, Feng Shen, Yu Chen, Tian Yang Tags: Research Paper Source Type: research
Development and evaluation of an ultrasound-triggered microbubble combined transarterial chemoembolization (TACE) formulation on rabbit VX2 liver cancer model
Conclusion: Incorporation of doxorubicin-loaded microbubble in the TACE formulation facilitated drug delivery to the tumor with real-time monitoring and enhanced the therapeutic efficacy of TACE. Thus, the enhanced TACE formulation may represent a new treatment strategy against liver cancer. (Source: Theranostics)
Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Doyeon Kim, Jae Hwan Lee, Hyungwon Moon, Minkyu Seo, Hyounkoo Han, Hongkeun Yoo, Howon Seo, Jingu Lee, Sujung Hong, Pilhan Kim, Hak Jong Lee, Jin Wook Chung, Hyuncheol Kim Tags: Research Paper Source Type: research
LT-171-861, a novel FLT3 inhibitor, shows excellent preclinical efficacy for the treatment of FLT3 mutant acute myeloid leukemia
Conclusions: Overall, this study not only identifies LT-171-861 as a potent FLT3 inhibitor, but also provides a rationale for the upcoming clinical trial of LT-171-861 in patients with AML and FLT3-ITD mutations. (Source: Theranostics)
Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Zhou Yu, Jiaying Du, Hui Hui, Shaoxin Kan, Tongxin Huo, Kai Zhao, Tao Wu, Qinglong Guo, Na Lu Tags: Research Paper Source Type: research
Facile engineering of silk fibroin capped AuPt bimetallic nanozyme responsive to tumor microenvironmental factors for enhanced nanocatalytic therapy
Conclusion: The objective of our investigation is to supply more useful insights on the development of SF-based nanocatalysts, which are specifically responsive to TME for extremely efficient tumor theranostics. (Source: Theranostics)
Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Ruihao Yang, Shiyan Fu, Ruidong Li, Lei Zhang, Zhigang Xu, Yang Cao, Hongjuan Cui, Yuejun Kang, Peng Xue Tags: Research Paper Source Type: research
Tertiary lymphoid organs are associated with the progression of kidney damage and regulated by interleukin-17A
Conclusion: These results indicate that TLOs are associated with the progression of kidney damage and regulated by IL-17A and may be effective targets for the treatment of kidney damage. (Source: Theranostics)
Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Ran Luo, Yichun Cheng, Dan Chang, Tingting Liu, Liu Liu, Guangchang Pei, Nanhui Zhang, Zufeng Wang, Kanglin Guo, Wei Chen, Ming Li, Li Fan, Chunxiu Zhang, Yueqiang Li, Wei Dai, Meiying Zuo, Yulin Xu, Ying Yao, Shuwang Ge, Gang Xu Tags: Research Paper Source Type: research
Transcriptomic analysis identifies a tumor subtype mRNA classifier for invasive non-functioning pituitary neuroendocrine tumor diagnostics
Conclusion: Our approach defined new characteristics in the core molecular network for patients at risk for invasive NF-PitNEt, representing a significant clinical advance in invasive PitNEt diagnostics. (Source: Theranostics)
Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Xinjie Bao, Gengchao Wang, Shan Yu, Jian Sun, Liu He, Hualu Zhao, Yanni Ma, Fang Wang, Xiaoshuang Wang, Renzhi Wang, Jia Yu Tags: Research Paper Source Type: research
A thermosensitive, reactive oxygen species-responsive, MR409-encapsulated hydrogel ameliorates disc degeneration in rats by inhibiting the secretory autophagy pathway
Conclusion: Secretory autophagy and associated IL-1β secretion contribute to the pathogenesis of disc degeneration, and MR409 can effectively inhibit this pathway. The ROS-responsive thermosensitive hydrogel encapsulated with MR409 is a potentially efficacious treatment for disc degeneration. (Source: Theranostics)
Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Qiangqiang Zheng, Haotian Shen, Zongrui Tong, Linxiang Cheng, Yuzi Xu, Zhiyun Feng, Shiyao Liao, Xiaojian Hu, Zongyou Pan, Zhengwei Mao, Yue Wang Tags: Research Paper Source Type: research
Macrophage membrane functionalized biomimetic nanoparticles for targeted anti-atherosclerosis applications
Conclusion: These results demonstrate that MM/RAPNPs could efficiently and safely inhibit the progression of AS. These biomimetic nanoparticles may be potential drug delivery systems for safe and effective anti-AS applications. (Source: Theranostics)
Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Yi Wang, Kang Zhang, Tianhan Li, Ali Maruf, Xian Qin, Li Luo, Yuan Zhong, Juhui Qiu, Sean McGinty, Giuseppe Pontrelli, Xiaoling Liao, Wei Wu, Guixue Wang Tags: Research Paper Source Type: research
Integrative analysis of long extracellular RNAs reveals a detection panel of noncoding RNAs for liver cancer
Conclusions: Our study revealed that different types of RNA variations related to cancer can be detected in plasma and identified a 3-RNA detection panel for liver cancer, especially for AFP-negative and early-stage patients. (Source: Theranostics)
Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Yumin Zhu, Siqi Wang, Xiaochen Xi, Minfeng Zhang, Xiaofan Liu, Weina Tang, Peng Cai, Shaozhen Xing, Pengfei Bao, Yunfan Jin, Weihao Zhao, Yinghui Chen, Huanan Zhao, Xiaodong Jia, Shanshan Lu, Yinying Lu, Lei Chen, Jianhua Yin, Zhi John Lu Tags: Research Paper Source Type: research
Intravital molecular imaging reveals the restrained capacity of CTLs in the killing of tumor cells in the liver
Conclusion: The quantitative characterization of these molecular and cellular events provides accurate information to evaluate the efficiency of cellular immunotherapy against tumors and understand the impact of an organ's immune status. (Source: Theranostics)
Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Lei Liu, Bolei Dai, Ruixue Li, Zheng Liu, Zhihong Zhang Tags: Research Paper Source Type: research
Hypoxia-induced myeloid derived growth factor promotes hepatocellular carcinoma progression through remodeling tumor microenvironment
Conclusions: We provided evidence that MYDGF could directly affect the self-renewal of liver CSCs, and indirectly aggravate the inflammatory microenvironment to accelerate the progression of HCC. (Source: Theranostics)
Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Xu Wang, Jie Mao, Tao Zhou, Xingyi Chen, Haoyang Tu, Jinyan Ma, Yixuan Li, Yushi Ding, Yong Yang, Hongxi Wu, Xinying Tang Tags: Research Paper Source Type: research
