Photosensitizer-driven nanoassemblies of homodimeric prodrug for self-enhancing activation and synergistic chemo-photodynamic therapy
Conclusion: Our findings offer a simple strategy to facilitate the assembly of homodimeric prodrugs and provide an efficient nanoplatform for chemo-photodynamic therapy. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Shenwu Zhang, Ziyue Wang, Zhiqiang Kong, Yuequan Wang, Xuanbo Zhang, Bingjun Sun, Haotian Zhang, Qiming Kan, Zhonggui He, Cong Luo, Jin Sun Tags: Research Paper Source Type: research
Genetic engineering cellular vesicles expressing CD64 as checkpoint antibody carrier for cancer immunotherapy
Conclusion: CD64-NVs are charismatic carriers to achieve both checkpoint blockade and immunomodulatory drugs for combined cancer immunotherapy. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Liyan Li, Qianwei Miao, Fanqiang Meng, Baoqi Li, Tianyuan Xue, Tianliang Fang, Zhirang Zhang, Jinxie Zhang, Xinyu Ye, Yang Kang, Xingding Zhang, Qian Chen, Xin Liang, Hongbo Chen, Xudong Zhang Tags: Research Paper Source Type: research
Repurposing 18F-FMISO as a PET tracer for translational imaging of nitroreductase-based gene directed enzyme prodrug therapy
Conclusions: 18F-FMISO NfsB NTR PET/CT imaging offered significant contrast between NTR+ and NTR- tumours and effective resolution of metastatic progression. Furthermore, 18F-FMISO NfsB NTR PET/CT imaging proved efficient in monitoring the two steps of GDEPT, in vivo NfsB NTR transduction and response to CB1954 prodrug therapy. These results support the repurposing of 18F-FMISO as a readily implementable PET imaging probe to be employed as companion diagnostic test for NTR-based GDEPT systems. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Gorka Ruiz de Garibay, Elvira Garc í a de Jal ó n, Endre Stigen, Kjetil B Lund, Mihaela Popa, Ben Davidson, Mireia Mayoral Safont, Cecilie B. Rygh, Heidi Espedal, Torill M Barrett, Bengt Erik Haug, Emmet McCormack Tags: Research Paper Source Type: research
MicroRNAs as theranostic markers in cardiac allograft transplantation: from murine models to clinical practice
Congestive heart failure affects about 23 million people worldwide, and cardiac allograft transplantation remains one of the last options for patients with terminal refractory heart failure. Besides the infectious or oncological complications, the prognosis of patients after heart transplantation is affected by acute cellular or antibody-mediated rejection and allograft vasculopathy development. Current monitoring of both conditions requires the performance of invasive procedures (endomyocardial biopsy sampling and coronary angiography or optical coherence tomography, respectively) that are costly, time-demanding, and non-...
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Jan Nov á k, T á ň a Mach á č kov á , Jan Krej č í , Julie Bienertov á -Va š k ů , Ond ř ej Slab ý Tags: Review Source Type: research
Female mice lacking ER β display excitatory/inhibitory synaptic imbalance to drive the pathogenesis of temporal lobe epilepsy
Conclusions: Our data provide novel insight into the pathogenesis of female TLE, and indicate ERβ provides a new therapeutic strategy for female TLE patients. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Zhongke Wang, Ruxin Xie, Xiaolin Yang, Huachun Yin, Xin Li, Tianyao Liu, Yuanyuan Ma, Junwei Gao, Zhenle Zang, Ruotong Ruan, Yang Li, Kaixuan Huang, Qingbo Chen, Kaifeng Shen, Shengqing Lv, Chunqing Zhang, Hui Yang, Maragret Warner, Jan-Ake Gustafsson, Sh Tags: Research Paper Source Type: research
Mechanically induced integrin ligation mediates intracellular calcium signaling with single pulsating cavitation bubbles
Conclusion: This approach to safely eliciting a Ca2+ response with cavitation microbubbles and the uncovered mechanism by which increased integrin-ligation mediates ATP release and Ca2+ signaling will inform new strategies to stimulate tissues with ultrasound and shockwaves. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Fenfang Li, Tae Hyun Park, George Sankin, Christopher Gilchrist, Defei Liao, Chon U Chan, Zheng Mao, Brenton D. Hoffman, Pei Zhong Tags: Research Paper Source Type: research
Current and future perspectives on functional molecular imaging in nephro-urology: theranostics on the horizon
In recent years, a paradigm shift from single-photon-emitting radionuclide radiotracers toward positron-emission tomography (PET) radiotracers has occurred in nuclear oncology. Although PET-based molecular imaging of the kidneys is still in its infancy, such a trend has emerged in the field of functional renal radionuclide imaging. Potentially allowing for precise and thorough evaluation of renal radiotracer urodynamics, PET radionuclide imaging has numerous advantages including precise anatomical co-registration with CT images and dynamic three-dimensional imaging capability. In addition, relative to scintigraphic approac...
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Yoshitaka Toyama, Rudolf A. Werner, Camilo A. Ruiz-Bedoya, Alvaro A. Ordonez, Kei Takase, Constantin Lapa, Sanjay K. Jain, Martin G. Pomper, Steven P. Rowe, Takahiro Higuchi Tags: Review Source Type: research
Temporal analysis of type 1 interferon activation in tumor cells following external beam radiotherapy or targeted radionuclide therapy
Conclusions: We report the time course of the STING-dependent IFN1 response following radiation in multiple murine tumor models. We show the potential of TRT to stimulate IFN1 activation that is comparable to that observed with EBRT and this may be critical to the therapeutic integration of TRT with immunotherapies. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Justin C. Jagodinsky, Won Jong Jin, Amber M. Bates, Reinier Hernandez, Joseph J. Grudzinski, Ian R. Marsh, Ishan Chakravarty, Ian S. Arthur, Luke M. Zangl, Ryan J. Brown, Erin J. Nystuen, Sarah E. Emma, Caroline Kerr, Peter M. Carlson, Raghava N. Sriraman Tags: Research Paper Source Type: research
Progressive stretch enhances growth and maturation of 3D stem-cell-derived myocardium
Conclusions: With the intention to simulate postnatal heart development, we have established techniques of tissue assembly and biomimetic culture that avoid tissue shrinkage and yield muscle fibers with contractility and compliance approaching the properties of adult myocardium. This study demonstrates that cultivation under progressive stretch is a feasible way to induce growth and maturation of stem cell-derived myocardium. The novel tissue-engineering approach fulfills important requirements of disease modelling and therapeutic tissue replacement. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Kun Lu, Thomas Seidel, Xiaochun Cao-Ehlker, Tatjana Dorn, Aarif Mohamed Nazeer Batcha, Christine Maria Schneider, Marie Semmler, Tilmann Volk, Alessandra Moretti, Andreas Dendorfer, Roland Tomasi Tags: Research Paper Source Type: research
Inner retinal injury in experimental glaucoma is prevented upon AAV mediated Shp2 silencing in a caveolin dependent manner
Conclusions: This study indicates that protective effects of Shp2 ablation under chronic experimental glaucoma conditions are dependent on Cav-1 in the retina, suggesting in vivo interactions between the two proteins. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Mojdeh Abbasi, Vivek K. Gupta, Nitin Chitranshi, Veer Gupta, Reza Ranjbaran, Rashi Rajput, Kanishka Pushpitha, Devaraj KB, Yuyi You, Ghasem Hosseini Salekdeh, Robert G. Parton, Mehdi Mirzaei, Stuart L. Graham Tags: Research Paper Source Type: research
A 9-kDa matricellular SPARC fragment released by cathepsin D exhibits pro-tumor activity in the triple-negative breast cancer microenvironment
Conclusions: Our study establishes a novel crosstalk between proteases and matricellular proteins in the tumor microenvironment through limited SPARC proteolysis, revealing a novel targetable 9-kDa bioactive SPARC fragment for new TNBC treatments. Our study will pave the way for the development of strategies for targeting bioactive fragments from matricellular proteins in TNBC. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Lindsay B Alcaraz, Aude Mallavialle, Timoth é e David, Danielle Derocq, Fr é d é ric Delolme, Cindy Dieryckx, Caroline Mollevi, Florence Boissi è re-Michot, Jo ë lle Simony-Lafontaine, Stanislas Du Manoir, Pitter F. Huesgen, Christopher M. Overall, S Tags: Research Paper Source Type: research
The therapeutic potential of inorganic polyphosphate: A versatile physiological polymer to control coronavirus disease (COVID-19)
Conclusions: This review summarizes the state of the art of the biotherapeutic potential of the polymer polyP and the findings from basic research and outlines future biomedical applications. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Hadrian Schepler, Xiaohong Wang, Meik Neufurth, Shunfeng Wang, Heinz C. Schr ö der, Werner E. G. M ü ller Tags: Review Source Type: research
A panel of selected serum protein biomarkers for the detection of aggressive prostate cancer
Conclusions: Multivariate panels of serum biomarkers identified in this study demonstrated clinically meaningful improvement over the performance of phi, and warrant further clinical validation, which may contribute to the management of PCa. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Jin Song, Shiyong Ma, Lori J. Sokoll, Rodrigo V. Eguez, Naseruddin H ö ti, Hui Zhang, Phaedre Mohr, Renu Dua, Dattatraya Patil, Kristen Douglas May, Sierra Williams, Rebecca Arnold, Martin G. Sanda, Daniel W. Chan, Zhen Zhang Tags: Research Paper Source Type: research
Therapeutic effects of dihydroartemisinin in multiple stages of colitis-associated colorectal cancer
Conclusion: Our study indicated that DHA could be a potent agent in managing the initiation and development of CAC without obvious side effects, warranting further clinical translation of DHA for CAC treatment. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Bingjun Bai, Fei Wu, Kangkang Ying, Yuzi Xu, Lina Shan, Yiming Lv, Xing Gao, Dengyong Xu, Jun Lu, Binbin Xie Tags: Research Paper Source Type: research
Deuterium oxide as a contrast medium for real-time MRI-guided endovascular neurointervention
Conclusion: Our study demonstrated that D2O can be used as a negative MRI contrast medium to guide endovascular neurointervention. The established D2O -MRI method is safe and quantitative, without the concern of contrast accumulation. These qualities make it an attempting approach for a variety of endovascular procedures. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Lin Chen, Jing Liu, Chengyan Chu, Zheng Han, Nirhbay Yadav, Jiadi Xu, Renyuan Bai, Verena Staedtke, Monica Pearl, Piotr Walczak, Peter van Zijl, Miroslaw Janowski, Guanshu Liu Tags: Research Paper Source Type: research
