Mechanically induced integrin ligation mediates intracellular calcium signaling with single pulsating cavitation bubbles

Conclusion: This approach to safely eliciting a Ca2+ response with cavitation microbubbles and the uncovered mechanism by which increased integrin-ligation mediates ATP release and Ca2+ signaling will inform new strategies to stimulate tissues with ultrasound and shockwaves.

Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Fenfang Li, Tae Hyun Park, George Sankin, Christopher Gilchrist, Defei Liao, Chon U Chan, Zheng Mao, Brenton D. Hoffman, Pei Zhong Tags: Research Paper Source Type: research