Molecular mechanisms of radioactive iodine refractoriness in differentiated thyroid cancer: Impaired sodium iodide symporter (NIS) expression owing to altered signaling pathway activity and intracellular localization of NIS
The advanced, metastatic differentiated thyroid cancers (DTCs) have a poor prognosis mainly owing to radioactive iodine (RAI) refractoriness caused by decreased expression of sodium iodide symporter (NIS), diminished targeting of NIS to the cell membrane, or both, thereby decreasing the efficacy of RAI therapy. Genetic aberrations (such as BRAF, RAS, and RET/PTC rearrangements) have been reported to be prominently responsible for the onset, progression, and dedifferentiation of DTCs, mainly through the activation of mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase (PI3K)/AKT signaling pathways. Eventua...
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Ji Min Oh, Byeong-Cheol Ahn Tags: Review Source Type: research
KAT6A, a novel regulator of β -catenin, promotes tumorigenicity and chemoresistance in ovarian cancer by acetylating COP1
Conclusions: Our findings suggest that the KAT6A/COP1/β-catenin signaling axis plays a critical role in ovarian cancer progression and that targeting the KAT6A/COP1/β-catenin signaling axis could be a novel strategy for treating ovarian cancer. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Wenxue Liu, Zhiyan Zhan, Meiying Zhang, Bowen Sun, Qiqi Shi, Fei Luo, Mingda Zhang, Weiwei Zhang, Yanli Hou, Xiuying Xiao, Yanxin Li, Haizhong Feng Tags: Research Paper Source Type: research
Perspectives on metals-based radioimmunotherapy (RIT): moving forward
Radioimmunotherapy (RIT) is FDA-approved for the clinical management of liquid malignancies, however, its use for solid malignancies remains a challenge. The putative benefit of RIT lies in selective targeting of antigens expressed on the tumor surface using monoclonal antibodies, to systemically deliver cytotoxic radionuclides. The past several decades yielded dramatic improvements in the quality, quantity, recent commercial availability of alpha-, beta- and Auger Electron-emitting therapeutic radiometals. Investigators have created new or improved existing bifunctional chelators. These bifunctional chelators bind radiome...
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Jordan M. White, Freddy E. Escorcia, Nerissa T. Viola Tags: Review Source Type: research
CircUbe3a from M2 macrophage-derived small extracellular vesicles mediates myocardial fibrosis after acute myocardial infarction
Conclusions: Our findings suggest that M2M-derived circUbe3a-containing SEVs promote the proliferation, migration, and phenotypic transformation of CFs by directly targeting the miR-138-5p/RhoC axis, which may also exacerbate myocardial fibrosis after acute myocardial infarction. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Yan Wang, Chaofu Li, Ranzun Zhao, Zhimei Qiu, Changyin Shen, Zhenglong Wang, Weiwei Liu, Wei Zhang, Junbo Ge, Bei Shi Tags: Research Paper Source Type: research
Multifunctional nanoplatforms co-delivering combinatorial dual-drug for eliminating cancer multidrug resistance
Clinically, the primary cause of chemotherapy failure belongs to the occurrence of cancer multidrug resistance (MDR), which directly leads to the recurrence and metastasis of cancer along with high mortality. More and more attention has been paid to multifunctional nanoplatform-based dual-therapeutic combination to eliminate resistant cancers. In addition to helping both cargoes improve hydrophobicity and pharmacokinetic properties, increase bioavailability, release on demand and enhance therapeutic efficacy with low toxic effects, these smart co-delivery nanocarriers can even overcome drug resistance. Here, this review wi...
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Xiao Wei, Mingzhu Song, Weijie Li, Jing Huang, Guang Yang, Yi Wang Tags: Review Source Type: research
DEPTOR stabilizes ErbB2 to promote the proliferation and survival of ErbB2-positive breast cancer cells
Conclusions: Our study reveals a novel mechanism by which DEPTOR promotes breast cancer cell proliferation and survival by stabilizing ErbB2. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Yanli Bi, Xiaoyu Chen, Bajin Wei, Linchen Wang, Longyuan Gong, Haomin Li, Xiufang Xiong, Yongchao Zhao Tags: Research Paper Source Type: research
Recent progress in nanomedicine for enhanced cancer chemotherapy
As one of the most important cancer treatment strategies, conventional chemotherapy has substantial side effects and leads easily to cancer treatment failure. Therefore, exploring and developing more efficient methods to enhance cancer chemotherapy is an urgently important problem that must be solved. With the development of nanotechnology, nanomedicine has showed a good application prospect in improving cancer chemotherapy. In this review, we aim to present a discussion on the significant research progress in nanomedicine for enhanced cancer chemotherapy. First, increased enrichment of drugs in tumor tissues relying on di...
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Guoqing Wei, Yu Wang, Guang Yang, Yi Wang, Rong Ju Tags: Review Source Type: research
Human endoglin-CD3 bispecific T cell engager antibody induces anti-tumor effect in vivo
Conclusions: Our study demonstrated the therapeutic potential of hEND-CD3/BiTE and provided a novel approach to clinical cancer treatment. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Liping Zhong, Wei Shi, Lu Gan, Xiuli Liu, Yu Huo, Pan Wu, Zhikun Zhang, Tao Wu, Hongmei Peng, Yong Huang, Yongxiang Zhao, Yulin Yuan, Zhiming Deng, Hongliang Tang Tags: Research Paper Source Type: research
Metal-phenolic networks: facile assembled complexes for cancer theranostics
In recent years, metal-phenolic networks (MPNs) have attracted increasing attention for the engineering of multi-functional platforms because of their easy fabrication processes, excellent physicochemical properties, outstanding biocompatibility, and promising theranostic applications. In this review, we summarize recent progress in the design, synthesis, shape-control, biocompatibility evaluation, and potential theranostic applications of MPNs, especially for cancer theranostics. First, we provide an overview of various MPN systems, relevant self-assembly procedures, and shape-controllable preparation. The in vitro and in...
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Wensheng Xie, Zhenhu Guo, Lingyun Zhao, Yen Wei Tags: Review Source Type: research
Neoantigen landscape in metastatic nasopharyngeal carcinoma
Conclusions: These results indicate that neoantigens are conducive to the guidance of clinical treatment, and personalized therapeutic vaccines for NPC deserve deeper basic and clinical investigations to make them feasible in the future. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Mei Lin, Xiao-Long Zhang, Rui You, Qi Yang, Xiong Zou, Kai Yu, You-Ping Liu, Ru-Hai Zou, Yi-Jun Hua, Pei-Yu Huang, Jin Wang, Qi Zhao, Xiao-Bing Jiang, Jun Tang, Yang-Kui Gu, Tao Yu, Gui-Ping He, Yu-Long Xie, Zhi-Qiang Wang, Ting Liu, Si-Yuan Chen, Zhi-Xia Tags: Research Paper Source Type: research
Phosphatidylserine-exposing tumor-derived microparticles exacerbate coagulation and cancer cell transendothelial migration in triple-negative breast cancer
Conclusion: Lactadherin, a biosensor that we developed, was used to study the extracellular vesicle distribution of PS, which revealed a novel PS+ BCMPs administrative axis that initiated a local coagulation cascade and facilitated metastatic colonization of circulating cancer cells. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Cong Zhang, Zhuowen Yang, Peng Zhou, Muxin Yu, Baorong Li, Yingmiao Liu, Jiaqi Jin, Wenhui Liu, Haijiao Jing, Jingwen Du, Jie Tian, Zhiyu Zhao, Jianxin wang, Yinzhu Chu, ChunMei Zhang, Valerie A Novakovic, Jialan Shi, Changjun Wu Tags: Research Paper Source Type: research
Single-cell transcriptome profiling reveals vascular endothelial cell heterogeneity in human skin
Conclusion: Our study provides a comprehensive characterization of EC features and heterogeneity in human dermis and sets the stage for future research in identifying disease-specific alterations of dermal ECs in various dermatoses. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Qingyang Li, Zhenlai Zhu, Lei Wang, Yiting Lin, Hui Fang, Jie Lei, Tianyu Cao, Gang Wang, Erle Dang Tags: Research Paper Source Type: research
Intelligent phototriggered nanoparticles induce a domino effect for multimodal tumor therapy
Conclusion: This intelligent drug delivery system induced a chain reaction generating multiple antitumor therapies after a single stimulus. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Xiao Xu, Chao Han, Can Zhang, Dan Yan, Chunling Ren, Lingyi Kong Tags: Research Paper Source Type: research
Apilimod alters TGF β signaling pathway and prevents cardiac fibrotic remodeling
Conclusions: Altogether, our findings propose a novel function for PIKfyve in the control of myocardial fibrotic remodeling and the TGFβ signaling pathway, therefore opening the way to new therapeutic perspectives to prevent adverse fibrotic remodeling using Apilimod treatment. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Mathieu Cinato, Laurie Guitou, Amira Saidi, Andrei Timotin, Erwan Sperazza, Thibaut Duparc, Sergey N. Zolov, Sai Srinivas Panapakkam Giridharan, Lois S. Weisman, Laurent O. Martinez, Jerome Roncalli, Oksana Kunduzova, Helene Tronchere, Frederic Boal Tags: Research Paper Source Type: research
Targeted delivery of neural progenitor cell-derived extracellular vesicles for anti-inflammation after cerebral ischemia
Conclusion: These results point to a rapid and easy strategy to produce targeting EVs and suggest a potential therapeutic agent for ischemic stroke. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Tian Tian, Lei Cao, Chuan He, Qing Ye, Ruyu Liang, Weiyan You, Huixin Zhang, Jiahuan Wu, Jinhai Ye, Bakhos A. Tannous, Jun Gao Tags: Research Paper Source Type: research
