CircUbe3a from M2 macrophage-derived small extracellular vesicles mediates myocardial fibrosis after acute myocardial infarction

Conclusions: Our findings suggest that M2M-derived circUbe3a-containing SEVs promote the proliferation, migration, and phenotypic transformation of CFs by directly targeting the miR-138-5p/RhoC axis, which may also exacerbate myocardial fibrosis after acute myocardial infarction.

Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Yan Wang, Chaofu Li, Ranzun Zhao, Zhimei Qiu, Changyin Shen, Zhenglong Wang, Weiwei Liu, Wei Zhang, Junbo Ge, Bei Shi Tags: Research Paper Source Type: research