Calcium phosphate engineered photosynthetic microalgae to combat hypoxic-tumor by in-situ modulating hypoxia and cascade radio-phototherapy
Conclusions: Our studies of this photosynthetic microsystem open up a new dimension for solving the radioresistance issue of hypoxic tumors. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Danni Zhong, Wanlin Li, Shiyuan Hua, Yuchen Qi, Tingting Xie, Yue Qiao, Min Zhou Tags: Research Paper Source Type: research
Vitamin C activates pyruvate dehydrogenase (PDH) targeting the mitochondrial tricarboxylic acid (TCA) cycle in hypoxic KRAS mutant colon cancer
Conclusion: We report a striking and previously non reported role of vitamin C in the regulation of the pyruvate dehydrogenase (PDH) activity, then modulating the TCA cycle and mitochondrial metabolism in KRAS mutant colon cancer. Potential impact of vitamin C in the clinical management of anti-EGFR chemoresistant colorectal neoplasias should be further considered. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Aiora Cenigaonandia-Campillo, Roberto Serna-Blasco, Laura G ó mez-Ocabo, Sonia Solanes-Casado, Natalia Ba ñ os-Herraiz, Laura Del Puerto-Nevado, Jose Antonio Ca ñ as, Mar í a Jes ú s Ace ñ ero, Jes ú s Garc í a-Foncillas, Ó scar Aguilera Tags: Research Paper Source Type: research
MiR-22 modulates brown adipocyte thermogenesis by synergistically activating the glycolytic and mTORC1 signaling pathways
Conclusions: Our findings identify miR-22 as a critical regulator in the control of thermogenesis in BAT and as a potential therapeutic target for human metabolic disorders. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Pengbo Lou, Xueyun Bi, Yuhua Tian, Guilin Li, Qianqian Kang, Cong Lv, Yongli Song, Jiuzhi Xu, Xiaole Sheng, Xu Yang, Ruiqi Liu, Qingyong Meng, Fazheng Ren, Maksim V. Plikus, Bin Liang, Bing Zhang, Huiyuan Guo, Zhengquan Yu Tags: Research Paper Source Type: research
Genome-wide CRISPR/Cas9 knockout screening uncovers a novel inflammatory pathway critical for resistance to arginine-deprivation therapy
Conclusion: We uncovered TREM1/CCL2 activation, in addition to restored ASS1 expression, as a key pathway involved in full ADI-resistance in breast and prostate cancer models. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Cheng-Ying Chu, Yi-Ching Lee, Cheng-Han Hsieh, Chi-Tai Yeh, Tsu-Yi Chao, Po-Hung Chen, I-Hsuan Lin, Tsung-Han Hsieh, Jing-Wen Shih, Chia-Hsiung Cheng, Che-Chang Chang, Ping-Sheng Lin, Yuan-Li Huang, Tsung-Ming Chen, Yun Yen, David K. Ann, Hsing-Jien Kung Tags: Research Paper Source Type: research
Nanodefensin-encased hydrogel with dual bactericidal and pro-regenerative functions for advanced wound therapy
Conclusion: Our results indicate that NDEFgel may be a promising dual-action therapeutic option for advanced wound management in the future. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Gan Luo, Yaqi Sun, Jue Zhang, Zhipeng Xu, Wuyuan Lu, Hanbin Wang, Yan Zhang, Hui Li, Zhengwei Mao, Shixin Ye, Baoli Cheng, Xiangming Fang Tags: Research Paper Source Type: research
Identification of theranostic factors for patients developing metastasis after surgery for early-stage lung adenocarcinoma
Conclusions: These results suggest that these four identified genes could be theranostic biomarkers for stratifying high-risk patients who develop relapse/metastasis in early-stage LUAD. Developing therapeutic approaches for the four biomarkers may benefit early-stage LUAD patients after surgery. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Wei-Chung Cheng, Chun-Yu Chang, Chia-Chien Lo, Chih-Ying Hsieh, Ting-Ting Kuo, Guan-Chin Tseng, Sze-Ching Wong, Shu-Fen Chiang, Kevin Chih-Yang Huang, Liang-Chuan Lai, Tzu-Pin Lu, K.S. Clifford Chao, Yuh-Pyng Sher Tags: Research Paper Source Type: research
Downregulated METTL14 accumulates BPTF that reinforces super-enhancers and distal lung metastasis via glycolytic reprogramming in renal cell carcinoma
Conclusions: Our study is the first to investigate the essential role of m6A modification and the METTL14/BPTF axis in the epigenetic and metabolic remodeling of mRCC, highlighting AU1 as a vital therapeutic candidate. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Chuanjie Zhang, Li Chen, Yihan Liu, Jingyi Huang, Ao Liu, Yang Xu, Yan Shen, Hongchao He, Danfeng Xu Tags: Research Paper Source Type: research
Polysaccharide mycophenolate-based nanoparticles for enhanced immunosuppression and treatment of immune-mediated inflammatory diseases
Conclusion: Our results indicated the polysaccharide mycophenolate-based NPs to be highly promising for IMID treatment. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Yuce Li, Yuchen Lou, Yu Chen, Jing Yang, Danqi Li, Biling Jiang, Jiajia Lan, Jingjing Wen, Yangxue Fu, Yamin Zhang, Juan Tao, Jintao Zhu Tags: Research Paper Source Type: research
Biocompatible AIEgen/p-glycoprotein siRNA@reduction-sensitive paclitaxel polymeric prodrug nanoparticles for overcoming chemotherapy resistance in ovarian cancer
Conclusion: Our findings demonstrated the Py-TPE/siRNA@PMP as a promising agent for the highly efficient treatment of PTX-resistant cells and overcoming the shortage of chemotherapy in ovarian cancer. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Jun Wu, Quan Wang, Xiaoqi Dong, Min Xu, Juliang Yang, Xiaoqing Yi, Biao Chen, Xiyuan Dong, Ying Wang, Xiaoding Lou, Fan Xia, Shixuan Wang, Jun Dai Tags: Research Paper Source Type: research
Dual-ligand supramolecular nanofibers inspired by the renin-angiotensin system for the targeting and synergistic therapy of myocardial infarction
Conclusion: A dual-ligand nanoplatform was successfully developed to achieve targeted and synergistic therapy against cardiac deterioration post-MI. We envision that the integration of multiple therapeutic agents through supramolecular self-assembly would offer new insight for the systematic and targeted treatment of cardiovascular diseases. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Zhanpeng Wen, Jie Zhan, Hekai Li, Guanghui Xu, Shaodan Ma, Jianwu Zhang, Zehua Li, Caiwen Ou, Zhimou Yang, Yanbin Cai, Minsheng Chen Tags: Research Paper Source Type: research
PRMT5 functionally associates with EZH2 to promote colorectal cancer progression through epigenetically repressing CDKN2B expression
Conclusion: PRMT5 functionally associates with EZH2 to promote CRC progression through epigenetically repressing CDKN2B expression. Thus, our findings raise the possibility that combinational intervention of PRMT5 and EZH2 may be a promising strategy for CRC therapy. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Liu Yang, Da-wei Ma, Yue-peng Cao, Dong-zheng Li, Xin Zhou, Ji-feng Feng, Jun Bao Tags: Research Paper Source Type: research
Environmental enrichment implies GAT-1 as a potential therapeutic target for stroke recovery
Conclusion: GAT-1 is a key molecular substrate of the effects of EE on network excitability and consequent stroke recovery and can serve as a novel therapeutic target for stroke treatment during the repair phase. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Yuhui Lin, Mengcheng Yao, Haiyin Wu, Feng Wu, Shiying Cao, Huanyu Ni, Jian Dong, Di Yang, Yanyu Sun, Xiaolin Kou, Jun Li, Hui Xiao, Lei Chang, Jin Wu, Yan Liu, Chunxia Luo, Dongya Zhu Tags: Research Paper Source Type: research
Granzyme A inhibition reduces inflammation and increases survival during abdominal sepsis
Conclusions: Our findings implicate GzmA as a key regulator of the inflammatory response during abdominal sepsis and provide solid evidences about its therapeutic potential for the treatment of this severe pathology. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Marcela Garz ó n-Titua ñ a, Jos é L Sierra-Monz ó n, Laura Comas, Llipsy Santiago, Tatiana Khaliulina-Ushakova, Iratxe Uranga-Murillo, Ariel Ramirez-Labrada, Elena Tapia, Elena Morte-Romea, Sonia Algarate, Ludovic Couty, Eric Camerer, Phillip I Bird, Tags: Research Paper Source Type: research
Impairment of type H vessels by NOX2-mediated endothelial oxidative stress: critical mechanisms and therapeutic targets for bone fragility in streptozotocin-induced type 1 diabetic mice
Conclusions: Diabetic osteopathy could be a chronic microvascular complication of T1DM. The impairment of type H vessels by NOX2-mediated endothelial oxidative stress might be an important contributor that can serve as a therapeutic target for T1DM-induced osteopathy. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Xiao-Fan Hu, Geng Xiang, Tian-Ji Wang, Yu-Bo Ma, Yang Zhang, Ya-Bo Yan, Xiong Zhao, Zi-Xiang Wu, Ya-Fei Feng, Wei Lei Tags: Research Paper Source Type: research
Paraventricular thalamic nucleus plays a critical role in consolation and anxious behaviors of familiar observers exposed to surgery mice
Conclusions: Mice show consolation behavior toward the sick. This behavior attenuates the anxious behavior of surgery mice. The orexin signaling in the PVT neurons play a critical role in the consolation of familiar observers toward surgery mice and their anxious behavior. Considering that about 50 million patients have surgery annually in the United States, our study represents the initial attempt to understand neural mechanisms for consolation and anxiety of a large number of people. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Qiuting Zeng, Weiran Shan, Hui Zhang, Jianjun Yang, Zhiyi Zuo Tags: Research Paper Source Type: research
