Genome-wide CRISPR/Cas9 knockout screening uncovers a novel inflammatory pathway critical for resistance to arginine-deprivation therapy

Conclusion: We uncovered TREM1/CCL2 activation, in addition to restored ASS1 expression, as a key pathway involved in full ADI-resistance in breast and prostate cancer models.

Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Cheng-Ying Chu, Yi-Ching Lee, Cheng-Han Hsieh, Chi-Tai Yeh, Tsu-Yi Chao, Po-Hung Chen, I-Hsuan Lin, Tsung-Han Hsieh, Jing-Wen Shih, Chia-Hsiung Cheng, Che-Chang Chang, Ping-Sheng Lin, Yuan-Li Huang, Tsung-Ming Chen, Yun Yen, David K. Ann, Hsing-Jien Kung Tags: Research Paper Source Type: research