Vitamin C activates pyruvate dehydrogenase (PDH) targeting the mitochondrial tricarboxylic acid (TCA) cycle in hypoxic KRAS mutant colon cancer

Conclusion: We report a striking and previously non reported role of vitamin C in the regulation of the pyruvate dehydrogenase (PDH) activity, then modulating the TCA cycle and mitochondrial metabolism in KRAS mutant colon cancer. Potential impact of vitamin C in the clinical management of anti-EGFR chemoresistant colorectal neoplasias should be further considered.

Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Aiora Cenigaonandia-Campillo, Roberto Serna-Blasco, Laura G ó mez-Ocabo, Sonia Solanes-Casado, Natalia Ba ñ os-Herraiz, Laura Del Puerto-Nevado, Jose Antonio Ca ñ as, Mar í a Jes ú s Ace ñ ero, Jes ú s Garc í a-Foncillas, Ó scar Aguilera Tags: Research Paper Source Type: research