Impairment of type H vessels by NOX2-mediated endothelial oxidative stress: critical mechanisms and therapeutic targets for bone fragility in streptozotocin-induced type 1 diabetic mice

Conclusions: Diabetic osteopathy could be a chronic microvascular complication of T1DM. The impairment of type H vessels by NOX2-mediated endothelial oxidative stress might be an important contributor that can serve as a therapeutic target for T1DM-induced osteopathy.

Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Xiao-Fan Hu, Geng Xiang, Tian-Ji Wang, Yu-Bo Ma, Yang Zhang, Ya-Bo Yan, Xiong Zhao, Zi-Xiang Wu, Ya-Fei Feng, Wei Lei Tags: Research Paper Source Type: research