Distinct placental molecular processes associated with early-onset and late-onset preeclampsia
Conclusion: These results suggest that early-onset and late-onset severe preeclampsia have different molecular mechanisms, whereas the late-onset mild preeclampsia may have no placenta-specific causal factors. A few regulators may be the key drivers of the dysregulated molecular pathways. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Zhonglu Ren, Yunfei Gao, Yue Gao, Guanmei Liang, Qian Chen, Sijia Jiang, Xiaoxue Yang, Cuixia Fan, Haizhen Wang, Jing Wang, Yi-Wu Shi, Chaoqun Xiao, Mei Zhong, Xinping Yang Tags: Research Paper Source Type: research
FGF19/SOCE/NFATc2 signaling circuit facilitates the self-renewal of liver cancer stem cells
Conclusions: FGF19/FGFR4 axis promotes the self-renewal of LCSCs via activating SOCE/NFATc2 pathway; in turn, NFATc2 transcriptionally activates FGF19 expression. Targeting this signaling circuit represents a potential strategy for improving the therapeutic efficacy of HCC. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Jingchun Wang, Huakan Zhao, Lu Zheng, Yu Zhou, Lei Wu, Yanquan Xu, Xiao Zhang, Guifang Yan, Halei Sheng, Rong Xin, Lu Jiang, Juan Lei, Jiangang Zhang, Yu Chen, Jin Peng, Qian Chen, Shuai Yang, Kun Yu, Dingshan Li, Qichao Xie, Yongsheng Li Tags: Research Paper Source Type: research
Identification and validation of hypoxia-derived gene signatures to predict clinical outcomes and therapeutic responses in stage I lung adenocarcinoma patients
Conclusions: In summary, the proposed hypoxia-derived signatures are promising biomarkers to predict clinical outcomes and therapeutic responses in stage I LUAD patients. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Run Shi, Xuanwen Bao, Kristian Unger, Jing Sun, Shun Lu, Farkhad Manapov, Xuanbin Wang, Claus Belka, Minglun Li Tags: Research Paper Source Type: research
Characterization of drug-induced human mitochondrial ADP/ATP carrier inhibition
Conclusion: Consequently, we have provided a straightforward model system to investigate AAC inhibition and have gained new insights into the chemical compound features important for inhibition. Better evaluation methods of drug-induced inhibition of mitochondrial transport proteins will contribute to the development of drugs with an enhanced safety profile. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Stephany Jaiquel Baron, Martin S. King, Edmund R.S. Kunji, Tom J.J. Schirris Tags: Research Paper Source Type: research
Single-cell melanoma transcriptomes depicting functional versatility and clinical implications of STIM1 in the tumor microenvironment
Conclusions: Overall, our results provide an integrated biological framework for understanding the functional and clinical consequences of cell-specific STIM1 expression in melanoma. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Henry Sung-Ching Wong, Wei-Chiao Chang Tags: Research Paper Source Type: research
Exosome-mediated delivery of an anti-angiogenic peptide inhibits pathological retinal angiogenesis
Conclusions: We used EXOs as a carrier for intraocular delivery of KV11. We showed that KV11 itself has an anti-angiogenic effect through retro-orbital injection, but that this effect was greatly enhanced when delivered with EXOs. Thus, this system has the potential to treat proliferative retinopathy via retro-orbital injection which is a less invasive manner compared with intravitreal injection. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Xue Dong, Yi Lei, Zeyang Yu, Tian Wang, Yi Liu, Gang Han, Xiaodan Zhang, Yiming Li, Yinting Song, Heping Xu, Mei Du, Haifang Yin, Xiaohong Wang, Hua Yan Tags: Research Paper Source Type: research
Kinomic profile in patient-derived glioma cells during hypoxia reveals c-MET-PI3K dependency for adaptation
Conclusions: Thus, our “bench to bedside (the use of patient-derived GPCs and xenografts for basic research) and back (validation with independent glioblastoma transcriptome databases)” analysis unravels the novel therapeutic indications of c-MET and PI3K/Akt inhibitors for the treatment of glioblastoma, and potentially other cancers, in the hypoxic tumor microenvironment. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Hong Sheng Cheng, Charlie Marvalim, Pengcheng Zhu, Cheng Lui Daniel Law, Zhi Yan Jeremy Low, Yuk Kien Chong, Beng Ti Ang, Carol Tang, Nguan Soon Tan Tags: Research Paper Source Type: research
Preventing tumor progression to the bone by induced tumor-suppressing MSCs
Conclusion: Collectively, the results showed an anti-tumor effect of iTS MSCs and suggested novel therapeutic approaches to suppress the progression of tumors into the bone. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Xun Sun, Kexin Li, Rongrong Zha, Shengzhi Liu, Yao Fan, Di Wu, Misato Hase, Uma K. Aryal, Chien-Chi Lin, Bai-Yan Li, Hiroki Yokota Tags: Research Paper Source Type: research
3D-bioprinting ready-to-implant anisotropic menisci recapitulate healthy meniscus phenotype and prevent secondary joint degeneration
Conclusion: 3D-bioprinted TCM meniscus not only restored the anisotropy of native healthy meniscus with PBV infiltration and better shape retention, but better maintained joint function and prevented secondary joint degeneration, which provided a new strategy for the clinical treatment of meniscus injury-related joint degenerative diseases. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Ye Sun, Yuxin Zhang, Qiang Wu, Feng Gao, Yongzhong Wei, Yimin Ma, Wenbo Jiang, Kerong Dai Tags: Research Paper Source Type: research
Development of nucleic acid aptamer-based lateral flow assays: A robust platform for cost-effective point-of-care diagnosis
Lateral flow assay (LFA) has made a paradigm shift in the in vitro diagnosis field due to its rapid turnaround time, ease of operation and exceptional affordability. Currently used LFAs predominantly use antibodies. However, the high inter-batch variations, error margin and storage requirements of the conventional antibody-based LFAs significantly impede its applications. The recent progress in aptamer technology provides an opportunity to combine the potential of aptamer and LFA towards building a promising platform for highly efficient point-of-care device development. Over the past decades, different forms of aptamer-ba...
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Tao Wang, Lanmei Chen, Arpitha Chikkanna, Suxiang Chen, Isabell Brusius, Nabayet Sbuh, Rakesh N. Veedu Tags: Review Source Type: research
Single-cell transcriptomic profiling provides insights into the toxic effects of Zearalenone exposure on primordial follicle assembly
Conclusions: This study showed that ZEN affected the status of germ cells and granulosa cells through the Hippo signaling pathway and blocked the assembly of PFs. This research contributes to our deeper understanding of the mechanisms of toxicity in different cell types and the disruption of normal intercellular signaling by ZEN exposure. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Yu Tian, Ming-Yu Zhang, Ai-Hong Zhao, Li Kong, Jun-Jie Wang, Wei Shen, Lan Li Tags: Research Paper Source Type: research
Tumor suppressor DRD2 facilitates M1 macrophages and restricts NF- κ B signaling to trigger pyroptosis in breast cancer
Conclusion: Collectively, this study novelly manifests the role of DRD2 in suppressing BrCa tumorigenesis, predicting prognosis and treatment response. And this study further reveals the critical role of DRD2 in educating M1 macrophages, restricting NF-κB signaling pathway and triggering different processes of programmed cell death in BrCa. Taking together, those findings represent a predictive and therapeutic target for BrCa. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Yiqing Tan, Ran Sun, Lei Liu, Dejuan Yang, Qin Xiang, Li Li, Jun Tang, Zhu Qiu, Weiyan Peng, Yuanyuan Wang, Lin Ye, Guosheng Ren, Tingxiu Xiang Tags: Research Paper Source Type: research
c-MYC-directed NRF2 drives malignant progression of head and neck cancer via glucose-6-phosphate dehydrogenase and transketolase activation
Conclusions: Carcinogens trigger c-MYC-directed NRF2 activation. Over-activation of NRF2 promotes malignant progression of HNSCC through reprogramming G6PD- and TKT-mediated nucleotide biosynthesis. Targeting NRF2-directed cellular metabolism is an effective strategy for development of novel treatments for head and neck cancer. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Ya-Chu Tang, Jenn-Ren Hsiao, Shih-Sheng Jiang, Jang-Yang Chang, Pei-Yi Chu, Ko-Jiunn Liu, Hsun-Lang Fang, Li-Mei Lin, Huang-Hui Chen, Yen-Wen Huang, Yu-Tsen Chen, Fang-Yu Tsai, Su-Fang Lin, Yung-Jen Chuang, Ching-Chuan Kuo Tags: Research Paper Source Type: research
Exosomal miR-125b-5p deriving from mesenchymal stem cells promotes tubular repair by suppression of p53 in ischemic acute kidney injury
Conclusion: MSC-exos exhibit preferential tropism to injured kidney and localize to proximal tubules in ischemic AKI. We demonstrate that MSC-exos ameliorate ischemic AKI and promote tubular repair by targeting the cell cycle arrest and apoptosis of TECs through miR-125b-5p/p53 pathway. This study provides a novel insight into the role of MSC-exos in renal tubule repair and highlights the potential of MSC-exos as a promising therapeutic strategy for AKI. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Jing-Yuan Cao, Bin Wang, Tao-Tao Tang, Yi Wen, Zuo-Lin Li, Song-Tao Feng, Min Wu, Dan Liu, Di Yin, Kun-Ling Ma, Ri-Ning Tang, Qiu-Li Wu, Hui-Yao Lan, Lin-Li Lv, Bi-Cheng Liu Tags: Research Paper Source Type: research
Cannabidiol attenuates pulmonary arterial hypertension by improving vascular smooth muscle cells mitochondrial function
Conclusions: Taken together, these findings confirm an important role for CBD in PAH pathobiology. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Xiaohui Lu, Jingyuan Zhang, Huijiao Liu, Wenqiang Ma, Leo Yu, Xin Tan, Shubin Wang, Fazheng Ren, Xiru Li, Xiangdong Li Tags: Research Paper Source Type: research
