Characterization of drug-induced human mitochondrial ADP/ATP carrier inhibition
Conclusion: Consequently, we have provided a straightforward model system to investigate AAC inhibition and have gained new insights into the chemical compound features important for inhibition. Better evaluation methods of drug-induced inhibition of mitochondrial transport proteins will contribute to the development of drugs with an enhanced safety profile.
Source: Theranostics - Category: Molecular Biology Authors: Stephany Jaiquel Baron, Martin S. King, Edmund R.S. Kunji, Tom J.J. Schirris Tags: Research Paper Source Type: research