Exosome-mediated delivery of an anti-angiogenic peptide inhibits pathological retinal angiogenesis
Conclusions: We used EXOs as a carrier for intraocular delivery of KV11. We showed that KV11 itself has an anti-angiogenic effect through retro-orbital injection, but that this effect was greatly enhanced when delivered with EXOs. Thus, this system has the potential to treat proliferative retinopathy via retro-orbital injection which is a less invasive manner compared with intravitreal injection.
Source: Theranostics - Category: Molecular Biology Authors: Xue Dong, Yi Lei, Zeyang Yu, Tian Wang, Yi Liu, Gang Han, Xiaodan Zhang, Yiming Li, Yinting Song, Heping Xu, Mei Du, Haifang Yin, Xiaohong Wang, Hua Yan Tags: Research Paper Source Type: research
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