A 9-kDa matricellular SPARC fragment released by cathepsin D exhibits pro-tumor activity in the triple-negative breast cancer microenvironment

Conclusions: Our study establishes a novel crosstalk between proteases and matricellular proteins in the tumor microenvironment through limited SPARC proteolysis, revealing a novel targetable 9-kDa bioactive SPARC fragment for new TNBC treatments. Our study will pave the way for the development of strategies for targeting bioactive fragments from matricellular proteins in TNBC.

Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Lindsay B Alcaraz, Aude Mallavialle, Timoth é e David, Danielle Derocq, Fr é d é ric Delolme, Cindy Dieryckx, Caroline Mollevi, Florence Boissi è re-Michot, Jo ë lle Simony-Lafontaine, Stanislas Du Manoir, Pitter F. Huesgen, Christopher M. Overall, S Tags: Research Paper Source Type: research