A role for intestinal alkaline phosphatase in preventing liver fibrosis

Conclusions: Endogenous IAP is decreased during liver fibrosis, perhaps contributing to the gut barrier dysfunction and worsening fibrosis. Oral IAP protects the gut barrier and further prevents the development of liver fibrosis via a TLR4-mediated mechanism.

Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Yang Liu, Paul M. Cavallaro, Byeong-Moo Kim, Tao Liu, Hongyan Wang, Florian K ü hn, Fatemeh Adiliaghdam, Enyu Liu, Robin Vasan, Ehsan Samarbafzadeh, Matthew Z. Farber, Junhui Li, Meng Xu, Vidisha Mohad, Michael Choi, Richard A. Hodin Tags: Research Paper Source Type: research