Hepatic miR-378 modulates serum cholesterol levels by regulating hepatic bile acid synthesis

Conclusions: TH-responsive hepatic miR-378 is capable of modulating serum cholesterol levels by regulating both the classic and alternative BA synthetic pathways. Our study not only identifies a previously undescribed role of hepatic miR-378 but also provides new cholesterol-lowering approaches.

Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Chao Sun, Wei Liu, Zhiqiang Lu, Yan Li, Shengnan Liu, Zhili Tang, Ying Yan, Zhiyang Li, Hua Feng, Duo Zhang, Yun Liu, Zhong-Ze Fang, Changtao Jiang, Qiurong Ding, Jingjing Jiang, Hao Ying Tags: Research Paper Source Type: research