The subcellular redistribution of NLRC5 promotes angiogenesis via interacting with STAT3 in endothelial cells

Conclusions: In the ischemic microenvironment, NLRC5 protein accumulates in the nucleus of ECs and enhances STAT3 transcriptional activity for angiogenesis. These findings establish NLRC5 as a novel modulator of VEGFA signaling, providing a new target for angiogenic therapy to foster tissue regeneration.

Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Xu Xu, Yefei Shi, Peipei Luan, Wenxin Kou, Bo Li, Ming Zhai, Shuangjie You, Qing Yu, Jianhui Zhuang, Weixia Jian, Mark W. Feinberg, Wenhui Peng Tags: Research Paper Source Type: research