ZEB1 enhances Warburg effect to facilitate tumorigenesis and metastasis of HCC by transcriptionally activating PFKM

Conclusions: Our study reveals a novel mechanism of ZEB1 in promoting HCC by activating the transcription of PFKM, establishing the direct link of ZEB1 to the promotion of glycolysis and Warburg effect and suggesting that inhibition of ZEB1 transcriptional activity toward PFKM may be a potential therapeutic strategy for HCC.

Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Yanming Zhou, Furong Lin, Tao Wan, Ai Chen, Huihui Wang, Bin Jiang, Wentao Zhao, Shan Liao, Shijie Wang, Guannan Li, Zhenzhen Xu, Jinyang Wang, Jia Zhang, Huanhuan Ma, Donghai Lin, Qinxi Li Tags: Research Paper Source Type: research