The combined induction of liver progenitor cells and the suppression of stellate cells by small molecules reverts chronic hepatic dysfunction
Conclusions: Hepatocyte-derived liver progenitor-like cells are crucial for liver regeneration during chronic hepatic injuries. The administration of HACY, which allowed the induction of endogenous CD24+ progenitor cells and the inactivation of HSCs, exerts beneficial effects in the treatment of liver fibrosis by re-establishing a balance favoring liver regeneration while preventing fibrotic responses.
Source: Theranostics - Category: Molecular Biology Authors: Wei-Jian Huang, Xu Zhou, Gong-Bo Fu, Min Ding, Hong-Ping Wu, Min Zeng, Hong-Dan Zhang, Ling-Yan Xu, Yi Gao, Hong-Yang Wang, He-Xin Yan Tags: Research Paper Source Type: research
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