Radiation-induced abscopal reproductive effect is driven by TNF- α /p38 MAPK/Rac1 axis in Sertoli cells

Conclusions: Our findings imply for the first time that YWHAZ-mediated Rac1 nuclear translocation plays central roles in RIARE, and TNF-α/p38 MAPK/Rac1 axis can be employed as a therapeutic target against RIARE for young male patients receiving hypofractionated radiotherapy.

Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Songling Hu, Lin Zhu, Yimeng Song, Xinrui Zhao, Qianping Chen, Yan Pan, Jianghong Zhang, Yang Bai, Haowen Zhang, Chunlin Shao Tags: Research Paper Source Type: research