Nodal-induced L1CAM/CXCR4 subpopulation sustains tumor growth and metastasis in colorectal cancer derived organoids

Conclusion: In conclusion, we demonstrated that a subpopulation of migrating L1CAMhigh/CXCR4high is essential for tumor progression. Together, these findings suggest that strategies aimed at modulating the Nodal signaling could have important clinical applications to inhibit colorectal cancer-derived metastasis.

Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Donatella Delle Cave, Xavier Hernando-Momblona, Marta Sevillano, Gabriella Minchiotti, Enza Lonardo Tags: Research Paper Source Type: research