An exosomal-carried short periostin isoform induces cardiomyocyte proliferation

Conclusions: Our results show, for the first time, that CPC-secreted exosomes promote cardiomyocyte cell cycle-reentry via a short periostin isoform expressed on their surfaces, whereas recombinant full-length periostin does not. These findings highlight isoform-specific roles of periostin in cardiomyocyte proliferation.

Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Carolina Balbi, Giuseppina Milano, Tudor E. Fertig, Edoardo Lazzarini, Sara Bolis, Yoshiaki Taniyama, Fumihiro Sanada, Dario Di Silvestre, Pierluigi Mauri, Mihaela Gherghiceanu, Thomas F. L ü scher, Lucio Barile, Giuseppe Vassalli Tags: Research Paper Source Type: research