Increased tumor distribution and expression of histidine‐rich plasmid polyplexes
ConclusionsAlthough mechanisms underlying the efficiency of gene expression are probably multifactorial, unpacking of the H2K polyplex within the tumor appears to have a significant role. Further development of these H2K polyplexes represents an attractive approach for plasmid–based therapies of cancer. This article is protected by copyright. All rights reserved. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - October 10, 2014 Category: Genetics & Stem Cells Authors: Qixin Leng, Szu‐Ting Chou, Puthupparampil V. Scaria, Martin C. Woodle, A. James Mixson Tags: Research Article Source Type: research
Correction of murine mucopolysaccharidosis type IIIA central nervous system pathology by intracerebroventricular lentiviral‐mediated gene delivery
ConclusionsThe current study demonstrates the efficacy of the intraventricular injection as a tool to target the brain with therapeutic genes in adult MPS IIIA mice, and provides evidence supporting this approach as potentially an effective means to treat CNS pathology in MPS IIIA patients. This article is protected by copyright. All rights reserved. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - September 1, 2014 Category: Genetics & Stem Cells Authors: Chantelle McIntyre, Ainslie L. K. Derrick Roberts, Sharon Byers, Donald S. Anson Tags: Research Article Source Type: research
Gene delivery targeted to oligodendrocytes using a lentiviral vector
ConclusionsLentiviral gene delivery using oligodendrocyte‐specific promoter may achieve widespread and long lasting expression selectively in oligodendrocytes offering a possibility for gene therapy in certain leukodystrophies, although the relatively low rates of oligodendrocyte transduction is a limitation that remains to be overcome. This article is protected by copyright. All rights reserved. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - September 1, 2014 Category: Genetics & Stem Cells Authors: Alexia Kagiava, Irene Sargiannidou, Stavros Bashiardes, Jan Richter, Natasa Schiza, Christina Christodoulou, Angela Gritti, Kleopas A. Kleopa Tags: Research Article Source Type: research
Development of receptor‐targeted gene delivery system using CXCR4 ligand‐conjugated cross‐linking peptides
ConclusionsCXCR4‐targeted cross‐linking peptides should be considered as useful tools for non‐viral gene delivery into tumor and mesenchymal stem cells. This article is protected by copyright. All rights reserved. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - September 1, 2014 Category: Genetics & Stem Cells Authors: Anna Egorova, Maria Bogacheva, Anastasia Shubina, Vladislav Baranov, Anton Kiselev Tags: Research Article Source Type: research
Optimization of a non‐viral transfection system to evaluate Cox‐2 controlled IL‐4 expression for osteoarthritis gene therapy in vitro
ConclusionWe hypothesize that this approach has significant potential to be translated into a useful anti‐inflammation therapy. Molecular tools such as the described therapeutic plasmid pave the way for a local‐controlled, self‐limiting gene therapy. This article is protected by copyright. All rights reserved. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - September 1, 2014 Category: Genetics & Stem Cells Authors: Annemarie Lang, Johannes Neuhaus, Moritz Pfeiffenberger, Erik Schröder, Igor Ponomarev, Yvonne Weber, Timo Gaber, Michael F.G. Schmidt Tags: Research Article Source Type: research
Conference Calendar
(Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - August 25, 2014 Category: Genetics & Stem Cells Tags: Conference Calendar Source Type: research
Low RNA translation activit limits the efficacy of hydrodynamic gene transfer to pig liver in vivo
ConclusionsThe results suggest that the low activity of mRNA translation limits the final efficacy of the gene transfer procedure. On the other hand, the gold nanoparticles study suggests that elongated DNA conformation could offer advantages in that the access of 15‐nm particles is very limited. Copyright © 2014 John Wiley & Sons, Ltd. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - August 25, 2014 Category: Genetics & Stem Cells Authors: Luis Sendra, Omar Carreño, Antonio Miguel, Eva Montalvá, María José Herrero, Francisco Orbis, Inmaculada Noguera, Domingo Barettino, Rafael López‐Andújar, Salvador F. Aliño Tags: Research Article Source Type: research
Improved nuclear delivery of antisense 2'‐Ome RNA by conjugation with the histidine‐rich peptide H5WYG
ConclusionsThe results of the present study show that the conjugation of 2'‐Ome antisense RNA to peptide H5WYG is a good strategy for improving its cytosol delivery, accumulation in the nucleus and antisense activity. Copyright © 2014 John Wiley & Sons, Ltd. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - August 25, 2014 Category: Genetics & Stem Cells Authors: Ulysse Asseline, Cristine Gonçalves, Chantal Pichon, Patrick Midoux Tags: Research Article Source Type: research
Issue Information
No abstract is available for this article. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - August 25, 2014 Category: Genetics & Stem Cells Tags: Issue Information Source Type: research
Conference Calendar
(Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - July 21, 2014 Category: Genetics & Stem Cells Tags: Conference Calendar Source Type: research
Sustained local delivery of oncolytic short hairpin RNA adenoviruses for treatment of head and neck cancer
ConclusionsMatrix‐mediated delivery of Ad‐containing shRNA with SELP hydrogels enhances therapeutic efficacy by tumor‐selective infection, spatiotemporal control and preservation of biologic activity. Copyright © 2014 John Wiley & Sons, Ltd. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - July 21, 2014 Category: Genetics & Stem Cells Authors: Se‐Hui Jung, Joung‐Woo Choi, Chae‐Ok Yun, Ji Young Yhee, Robert Price, Sun Hwa Kim, Ick Chan Kwon, Hamidreza Ghandehari Tags: Research Article Source Type: research
Adeno‐associated virus 8‐mediated gene therapy for choroideremia: preclinical studies in in vitro and in vivo models
ConclusionsAAV8 is a promising vector for human clinical gene therapy trials for choroideremia. Copyright © 2014 John Wiley & Sons, Ltd. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - July 21, 2014 Category: Genetics & Stem Cells Authors: Aaron Black, Vidyullatha Vasireddy, Daniel C. Chung, Albert M. Maguire, Rajashekhar Gaddameedi, Tania Tolmachova, Miguel Seabra, Jean Bennett Tags: Research Article Source Type: research
Issue Information
No abstract is available for this article. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - July 21, 2014 Category: Genetics & Stem Cells Tags: Issue Information Source Type: research
Designing a gold nanoparticle based nanocarrier for MicroRNA transfection into the prostate and breast cancer cells
ConclusionIn conclusion, we showed that the AuNPs help the effective in vitro delivery of miR‐145 into the cancer cells. Copyright © 2014 John Wiley & Sons, Ltd. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - July 1, 2014 Category: Genetics & Stem Cells Authors: Asli Ekin, Omer Faruk Karatas, Mustafa Culha, Mustafa Ozen Tags: Research Article Source Type: research
Angiogenic gene therapy does not cause retinal pathology
This article is protected by copyright. All rights reserved. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - July 1, 2014 Category: Genetics & Stem Cells Authors: Verena Prokosch, Tobias Stupp, Kristina Spaniol, Emmanuel Pham, Sigrid Nikol Tags: Research Article Source Type: research
