Increased tumor distribution and expression of histidine‐rich plasmid polyplexes

ConclusionsAlthough mechanisms underlying the efficiency of gene expression are probably multifactorial, unpacking of the H2K polyplex within the tumor appears to have a significant role. Further development of these H2K polyplexes represents an attractive approach for plasmid–based therapies of cancer. This article is protected by copyright. All rights reserved.

Source: The Journal of Gene Medicine - October 10, 2014 Category: Genetics & Stem Cells Authors: Qixin Leng, Szu‐Ting Chou, Puthupparampil V. Scaria, Martin C. Woodle, A. James Mixson Tags: Research Article Source Type: research