Pulmonary Vasculature Directed Adenovirus Increases Epithelial Lining Fluid Alpha‐1 Antitrypsin Levels
ConclusionsIn addition to advancing us closer to clinically viable gene therapy for A1AT, by maximizing protein production at the site of action, this represents a significant technical advancement in the field of systemically delivered pulmonary targeted gene therapy. It also provides an alternative to the previous limitations of hepatic viral transduction and associated toxicities. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - December 1, 2015 Category: Genetics & Stem Cells Authors: Maurizio Buggio, Christopher Towe, Anand Annan, Sergey Kaliberov, Zhi Hong Lu, Calvin Stephens, Jeffrey M. Arbeit, David T. Curiel Tags: Research Article Source Type: research
A single adenovirus‐mediated relaxin delivery attenuates established liver fibrosis in rats
ConclusionsA single adenoviral delivery of RLX in the liver attenuated established hepatic fibrosis by suppressing collagen cross‐linking and enhancing collagen degradation. This article is protected by copyright. All rights reserved. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - December 1, 2015 Category: Genetics & Stem Cells Authors: Ja Kyung Kim, Jung Il Lee, Yong‐Han Paik, Chae‐Ok Yun, Hye Young Chang, Su Yeon Lee, Kwan Sik Lee Tags: Research Article Source Type: research
Anguilla japonica lectin 1 delivery through adenovirus vector induces apoptotic cancer cell death through interaction with PRMT5
ConclusionsOur results suggested that PRMT5‐E2F‐1 pathway may act as a common target for exogenous lectins including AJL1, and the cellular response to exogenous AJL1 may suggest a novel agent for cancer gene therapy. This article is protected by copyright. All rights reserved. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - October 1, 2015 Category: Genetics & Stem Cells Authors: Gongchu Li, Yajun Gao, Lianzhen Cui, Liqin Wu, Xinyan Yang, Jing Chen Tags: Research Article Source Type: research
Application of HIF‐1α by gene therapy enhances angiogenesis and osteogenesis in alveolar bone defect regeneration
ConclusionOverexpression of HIF‐1α by gene therapy may be a useful method to enhance alveolar bone defect osteogenesis and angiogenesis. This article is protected by copyright. All rights reserved. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - October 1, 2015 Category: Genetics & Stem Cells Authors: zhang yang, Huang Jiao, Wang Chao, Zhang Yan, Hu Changhong, Guangyue Li, Xu Ling Tags: Research Article Source Type: research
Conference Calendar
(Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - September 17, 2015 Category: Genetics & Stem Cells Tags: Conference Calendar Source Type: research
Ninth Australasian Gene and Cell Therapy Society Meeting
(Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - September 17, 2015 Category: Genetics & Stem Cells Authors: Abbygail A. Foster, Nikki L. Ross, Millicent O. Sullivan Tags: Abstract section Source Type: research
Long‐term glycemic control with hepatic insulin gene therapy in streptozotocin‐diabetic mice
ConclusionsOur studies demonstrate the possibility for long‐term glycemic correction following AAV‐mediated HIGT in mice. However, the dose–response relationship is irregular, and metabolic responsiveness may be less than that observed in rats. Copyright © 2015 John Wiley & Sons, Ltd. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - September 17, 2015 Category: Genetics & Stem Cells Authors: Peter M. Thulé, Adam G. Campbell, Dingwu Jia, Yulin Lin, Shou You, Sara Paveglio, Darin E. Olson, Miroslaw Kozlowski Tags: Research Article Source Type: research
Issue Information
No abstract is available for this article. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - September 17, 2015 Category: Genetics & Stem Cells Tags: Issue Information Source Type: research
Important role of phosphoramido linkage in imidazole‐based dioleyl helper lipids for liposome stability and primary cell transfection
ConclusionThis hybrid dioleyl linker composition of DOSP/MM27 led to higher transfection efficiency in cell lines and in primary cells compared to complexes with homogeneous dioleyl linker. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - August 9, 2015 Category: Genetics & Stem Cells Authors: Mathieu Mével, Thomas Haudebourg, Thibault Colombani, Pauline Peuziat, Laurence Dallet, Benoît Chatin, Olivier Lambert, Mathieu Berchel, Tristan Montier, Paul‐Alain Jaffrès, Pierre Lehn, Bruno Pitard Tags: Research Article Source Type: research
Effects of particle size and binding affinity for siRNA on the cellular processing, intestinal permeation, and anti‐inflammatory efficacy of polymeric nanoparticles
ConclusionNanoparticles with particle size of 450 nm or more balanced binding affinity for siRNA might be preferable for the treatment of ulcerative colitis. This article is protected by copyright. All rights reserved. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - August 9, 2015 Category: Genetics & Stem Cells Authors: Wenyue Cheng, Cui Tang, Chunhua Yin Tags: Research Article Source Type: research
Regulated expression of murine Cd40l by a lentiviral vector transcriptionally targeted through its endogenous promoter
This article is protected by copyright. All rights reserved. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - July 29, 2015 Category: Genetics & Stem Cells Authors: Pablo Fernández‐Rubio, Sara Torres‐Rusillo, Ignacio J. Molina Tags: Research Article Source Type: research
Conference Calendar
(Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - July 24, 2015 Category: Genetics & Stem Cells Tags: Conference Calendar Source Type: research
Redesigned Escherichia coli cytosine deaminase: a new facet of suicide gene therapy
ConclusionsWe report a novel bacterial CD mutant that provided a superior alternate to the wtCD suicide gene. The F186W mutant required a much lower dose of 5‐FC to reach its IC50, thus minimizing the systemic side effects of large doses of 5‐FC as required for wtCD. Copyright © 2015 John Wiley & Sons, Ltd. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - July 24, 2015 Category: Genetics & Stem Cells Authors: Asif Raza, V. Kohila, Siddhartha Sankar Ghosh Tags: Research Article Source Type: research
Issue Information
No abstract is available for this article. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - July 24, 2015 Category: Genetics & Stem Cells Tags: Issue Information Source Type: research
Adenovirus mediated delivery of factor H attenuates complement C3 induced pathology in the murine retina: a potential gene therapy for AMD
ConclusionsC3‐induced pathology in murine retina can be attenuated by Ad mediated expression of Factor H. Expression of Factor H is worthy of further study as a potential gene therapy for AMD. This article is protected by copyright. All rights reserved. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - June 1, 2015 Category: Genetics & Stem Cells Authors: Siobhan M. Cashman, Jessica Gracias, Mehreen Adhi, Rajendra Kumar‐Singh Tags: Research Article Source Type: research
