Pulmonary Vasculature Directed Adenovirus Increases Epithelial Lining Fluid Alpha‐1 Antitrypsin Levels

ConclusionsIn addition to advancing us closer to clinically viable gene therapy for A1AT, by maximizing protein production at the site of action, this represents a significant technical advancement in the field of systemically delivered pulmonary targeted gene therapy. It also provides an alternative to the previous limitations of hepatic viral transduction and associated toxicities.

Source: The Journal of Gene Medicine - December 1, 2015 Category: Genetics & Stem Cells Authors: Maurizio Buggio, Christopher Towe, Anand Annan, Sergey Kaliberov, Zhi Hong Lu, Calvin Stephens, Jeffrey M. Arbeit, David T. Curiel Tags: Research Article Source Type: research