Inflammation‐induced transgene expression in genetically engineered equine mesenchymal stem cells
ConclusionsThe results of the present study demonstrate that on demand transgene expression from the NFkB‐responsive promoter using naturally occurring inflammatory cytokines can be induced in undifferentiated and chondrogenically differentiated equine MSCs. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - March 31, 2016 Category: Genetics & Stem Cells Authors: Simone Gabner, Juraj Hlavaty, Karsten Velde, Matthias Renner, Florien Jenner, Monika Egerbacher Tags: Research Article Source Type: research
Announcement
(Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - March 22, 2016 Category: Genetics & Stem Cells Authors: Tina Wang, James Murphy Tags: Announcement Source Type: research
Issue Information
No abstract is available for this article. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - March 22, 2016 Category: Genetics & Stem Cells Tags: Issue Information Source Type: research
Lentiviral expression of GAD67 and CCK promoter‐driven opsins to target interneurons in vitro and in vivo
ConclusionsLV‐CCK‐NpHR2.0‐EYFP may be useful to target CCK+ interneurons in culture. GAD67/CCK‐driven lentiviral constructs are expressed in vivo, but expression is not specific for interneurons. Overall, expression levels are low compared to opsins driven by pyramidal cell promoters. Better understanding of GAD67 and CCK promoter structure or alternative techniques are required to reliably target opsins to interneurons using viral vectors. This article is protected by copyright. All rights reserved. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - January 29, 2016 Category: Genetics & Stem Cells Authors: Laura Mantoan Ritter, Douglas C. Macdonald, Georg Ritter, David Escors, Francesca Chiara, Anna Cariboni, Stephanie Schorge, Dimitri M. Kullmann, Mary Collins Tags: Research Article Source Type: research
CYP gene family variants as a potential risk factors in drug addiction in Han Chinese
ConclusionOur findings show that allelic and genotypic in CYP3A4 and CYP1A2 are significantly associated with a reduced risk of drug addiction in Xi'an Han Chinese individuals. The result is needed to be further confirmed. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - December 31, 2015 Category: Genetics & Stem Cells Authors: Hongxing Zhang, Qi Yang, Wenkai Zheng, Yongri Ouyang, Min Yang, Fengjiao Wang, Tianbo Jin, Ji Zhang, Zhenyuan Wang Tags: Research Article Source Type: research
Intramyocardial Injection of Serca2a‐Expressing Lentivirus Improves Myocardial Function in Doxorubicin‐Induced Heart Failure
ConclusionsSERCA2a gene transfer improves significantly left ventricle function and dimensions in doxorubicin‐induced cardiomyopathy thus making LV‐SERCA2a gene transfer an attractive treatment modality for doxorubicin‐induced heart failure. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - December 31, 2015 Category: Genetics & Stem Cells Authors: Minttu Mattila, Juha Koskenvuo, Mirva Söderström, Kim Eerola, Mikko Savontaus Tags: Research Article Source Type: research
Sendai Viroplexes for EGF Receptor‐directed Delivery of IL12 and Salmosin Genes to Cancer Cells
ConclusionThis study suggests that anti‐EGFR viroplexes can be utilized as an effective strategy for tumor‐directed gene delivery. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - December 31, 2015 Category: Genetics & Stem Cells Authors: Jung Seok Kim, Min Woo Kim, Hwa Yeon Jeong, Seong Jae Kang, Sang Il Park, Yeon Kyung Lee, Hong Sung Kim, Keun Sik Kim, Yong Serk Park Tags: Research Article Source Type: research
Adenovirus‐Mediated artificial miRNA against Human Fibrinogen Like Protein 2 Inhibits Hepatocellular Carcinoma Growth
ConclusionsHFGL2 might be a potential target for controlling angiogenesis in HCC and hfgl2 gene silencing via miRNA may be an alternative strategy for management of HCC. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - December 31, 2015 Category: Genetics & Stem Cells Authors: Ming Wang, Junhui Liu, Dong Xi, Xiaoping Luo, Qin Ning Tags: Research Article Source Type: research
Cancer‐specific Promoters for Expression‐targeted Gene Therapy: ran, brms1, and mcm5
Abstract
BackgroundTo expand the library of promoters that can be used for expression‐targeted gene delivery to cancer cells, the specificity and strength of expression were evaluated for the promoters of three cancer‐related genes: RAS‐related nuclear protein (pran), breast cancer metastasis suppressor 1 (pbrms1), and minichromosome maintenance complex component 5 (pmcm5).
MethodsThe expression of reporter genes under the control of these promoters demonstrated selectivity in cancer cell lines of breast, prostate, and ovarian origins, versus a panel of normal cell types. The pran was next used to regulate the expres...
Source: The Journal of Gene Medicine - December 31, 2015 Category: Genetics & Stem Cells Authors: Xg Chen, Je Scapa, Dx Liu, Wt Godbey Tags: Research Article Source Type: research
Malaria sporozoite protein expression enhances baculovirus‐mediated gene transfer to hepatocytes.
ConclusionsBVs expressing CSP or TRAP in the ectodomain could represent a promising hepatocyte‐specific gene delivery methodology. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - December 31, 2015 Category: Genetics & Stem Cells Authors: Takahiko Tamura, Chiaki Kawabata, Shunsuke Matsushita, Miako Sakaguchi, Shigeto Yoshida Tags: Research Article Source Type: research
Conference Calendar
(Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - December 11, 2015 Category: Genetics & Stem Cells Tags: Conference Calendar Source Type: research
Effects of particle size and binding affinity for small interfering RNA on the cellular processing, intestinal permeation and anti‐inflammatory efficacy of polymeric nanoparticles
ConclusionsNanoparticles with a particle size of 450 nm or balanced binding affinity for siRNA might be preferable for the treatment of ulcerative colitis. Copyright © 2015 John Wiley & Sons, Ltd. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - December 11, 2015 Category: Genetics & Stem Cells Authors: Wenyue Cheng, Cui Tang, Chunhua Yin Tags: Research Article Source Type: research
Adenovirus‐mediated delivery of Factor H attenuates complement C3 induced pathology in the murine retina: a potential gene therapy for age‐related macular degeneration
ConclusionsC3‐induced pathology in murine retina can be attenuated by Ad‐mediated expression of Factor H. Expression of Factor H is worthy of further study as a potential gene therapy for AMD. Copyright © 2015 John Wiley & Sons, Ltd. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - December 11, 2015 Category: Genetics & Stem Cells Authors: Siobhan M. Cashman, Jessica Gracias, Mehreen Adhi, Rajendra Kumar‐Singh Tags: Research Article Source Type: research
Issue Information
No abstract is available for this article. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - December 11, 2015 Category: Genetics & Stem Cells Tags: Issue Information Source Type: research
Combined ultrasound targeted microbubble destruction and Polyethylenimine mediated plasmid DNA delivery to rat retina: enhanced efficiency and accelerated expression
ConclusionsThe key advantage of this article is that enhanced and accelerated pDNA expression can be achieved in the retina/ retinal pigment epithelium (RPE) cells in vivo by UTMD physical techniques combined with PEI chemical vector. This study provides useful basic information for further in vivo retinal gene therapy work. This article is protected by copyright. All rights reserved. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - December 1, 2015 Category: Genetics & Stem Cells Authors: Hongli Li, Jin Qian, Chunfang Yao, Caifeng Wan, Fenghua Li Tags: Research Article Source Type: research
