Combination of Sequence‐defined Oligoaminoamides with Transferrin‐polycation Conjugates for Receptor‐Targeted Gene Delivery
ConclusionsUtilizing the synergistic effects of Tf for receptor targeting and oligomer for packaging and endolysosomal escape, an efficient gene delivery carrier was developed. The mixed polyplex containing Tf‐polycation conjugates and histidinylated 4‐arm oligomer with Stp or Gtt building blocks exhibited highest gene transfection efficiency in TfR over expressing human tumor cell lines. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - June 1, 2015 Category: Genetics & Stem Cells Authors: Wei Zhang, Wolfgang Rödl, Dongsheng He, Markus Döblinger, Ulrich Lächelt, Ernst Wagner Tags: Research Article Source Type: research
Potent immunotherapy against well‐established thymoma using adoptively transferred transgene IL‐6‐engineered dendritic cell‐stimulated CD8+ T‐cells with prolonged survival and enhanced cytotoxicity
ConclusionsOur data suggest that AdVIL‐6‐transfected DC‐stimulated CD8+ T cells with potent cytotoxicity and survival advantage may serve as an effective adoptive CD8+ T‐cell immunotherapy strategy for anti‐tumor treatment. This article is protected by copyright. All rights reserved. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - June 1, 2015 Category: Genetics & Stem Cells Authors: Kalpana Kalyanasundaram Bhanumathy, Bei Zhang, Yufeng Xie, Aizhang Xu, Xin Tan, Jim Xiang Tags: Research Article Source Type: research
Conference Calendar
(Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - May 15, 2015 Category: Genetics & Stem Cells Tags: Conference Calendar Source Type: research
The dependence of efficiency of transmembrane molecular transfer using electroporation on medium viscosity
ConclusionsThese findings demonstrate that transfection is very susceptible to medium viscosity and highlights the importance of the electrophoretic component in experiments when a considerable transfection level is needed. Copyright © 2015 John Wiley & Sons, Ltd. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - May 15, 2015 Category: Genetics & Stem Cells Authors: Sandra Sungailaitė, Paulius Ruzgys, Ingrida Šatkauskienė, Karolina Čepurnienė, Saulius Šatkauskas Tags: Research Article Source Type: research
Issue Information
No abstract is available for this article. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - May 15, 2015 Category: Genetics & Stem Cells Tags: Issue Information Source Type: research
Conference Calendar
(Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - March 27, 2015 Category: Genetics & Stem Cells Tags: Conference Calendar Source Type: research
α‐ l‐iduronidase gene‐based therapy using the phiC31 system to treat mucopolysaccharidose type I mice
ConclusionsphiC31‐mediated gene therapy resulted in an important improvement in IDUA –/– mice, including locomotion, although the obstacles that need to be overcome to enable long‐term gene therapy for MPSI are also noted. Copyright © 2015 John Wiley & Sons, Ltd. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - March 27, 2015 Category: Genetics & Stem Cells Authors: Roberta Sessa Stilhano, Priscila Keiko Matsumoto Martin, Suely Maymone Melo, Vivian Yochiko Samoto, Giovani Bravin Peres, Yara Maria Correa Silva Michelacci, Flavia Helena Silva, Vanessa Gonçalves Pereira, Vania D'Almeida, Adriana Taveira Cruz, Miriam Ga Tags: Research Article Source Type: research
Issue Information
No abstract is available for this article. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - March 27, 2015 Category: Genetics & Stem Cells Tags: Issue Information Source Type: research
Long‐Term Glycemic Control with Hepatic Insulin Gene Therapy in STZ‐Diabetic Mice
ConclusionsOur studies demonstrate the possibility for long term glycemic correction following AAV mediated HIGT in mice. However, the dose response relationship is irregular, and metabolic responsiveness may be less than observed in rats. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - March 1, 2015 Category: Genetics & Stem Cells Authors: Peter M. Thulé, Adam G. Campbell, Dingwu Jia, Yulin Lin, Shou You, Sara Paveglio, Darin E. Olson, Miroslaw Kozlowski Tags: Research Article Source Type: research
9th Australasian Gene and Cell Therapy Society Meeting
The Australasian Gene and Cell Therapy Society (AGCTS) held its Ninth Biennial Meeting between 29th April and 1st May 2015. The AGCTS acknowledges and thanks the Journal of Gene Medicine for making the abstracts presented during the meeting available to the international research community. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - March 1, 2015 Category: Genetics & Stem Cells Tags: Abstracts section Source Type: research
Redesigned E.coli cytosine deaminase: a new facet of suicide gene therapy
ConclusionWe have presented a novel bacterial CD mutant, which provided a superior alternate to wild type CD suicide gene. F186W mutant required a much less dose of 5‐FC to reach its IC50, thus minimizing the systemic side effects of large doses of 5‐FC as required for wtCD. This article is protected by copyright. All rights reserved. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - March 1, 2015 Category: Genetics & Stem Cells Authors: Md. Asif Raza, V. Kohila, Siddhartha Sankar Ghosh Tags: Research Article Source Type: research
Temporal endogenous gene expression profiles in response to polymer‐mediated transfection and profile comparison to lipid‐mediated transfection
ConclusionsThe identified genes and pharmacologic agents provide targets for improving transfection systems, although polyplex or lipoplex dependencies must be considered. This article is protected by copyright. All rights reserved. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - February 9, 2015 Category: Genetics & Stem Cells Authors: Timothy M. Martin, Sarah A. Plautz, Angela K. Pannier Tags: Research Article Source Type: research
Effective multiple oral administration of reverse genetics engineered infectious bursal disease virus in mice in the presence of neutralizing antibodies
ConclusionsRepeat oral administration of R903/78 was successful despite the presence of neutralizing antibodies. Single oral and IV administration indicated that IBDV does not replicate in mammalian liver alleviating some safety related concerns. These data supports the development of an orally delivered anti‐HBV/HCV viral agent for human use. This article is protected by copyright. All rights reserved. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - January 1, 2015 Category: Genetics & Stem Cells Authors: Ákos Hornyák, Kai S. Lipinski, Tamás Bakonyi, Petra Forgách, Ernő Horváth, Attila Farsang, Susan J. Hedley, Vilmos Palya, Tibor Bakács, Imre Kovesdi Tags: Research Article Source Type: research
Adeno‐associated virus mediated delivery of an engineered protein that combines the complement inhibitory properties of CD46, CD55 and CD59
ConclusionsWhen delivered to mice in vivo via an AAV vector, SACT and DTAC are capable of limiting human complement mediated damage. SACT and DTAC merit further study as potential therapies for complement mediated disorders when delivered via a gene therapy approach. This article is protected by copyright. All rights reserved. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - January 1, 2015 Category: Genetics & Stem Cells Authors: Derek Leaderer, Siobhan M. Cashman, Rajendra Kumar‐Singh Tags: Research Article Source Type: research
Conference Calendar
(Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - December 9, 2014 Category: Genetics & Stem Cells Tags: Conference Calendar Source Type: research
